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Journal of Assisted Reproduction and Genetics

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01-12-2007 | Symposium of the Aging Ovary

Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function

Authors: David Barad, Hyama Brill, Norbert Gleicher

Published in: Journal of Assisted Reproduction and Genetics | Issue 12/2007

Abstract

Objective

We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function.

Design

This is a case control study of 190 women with diminished ovarian function. The study group includes 89 patients who used supplementation with 75 mg daily of oral, micronized DHEA for up to 4 months prior to entry into in vitro fertilization (IVF). The control group is composed of 101 couples who received infertility treatment, but did not use DHEA. The primary outcome was clinical pregnancy after the patient’s initial visit. We developed a Cox proportional hazards model to compare the proportional hazards of pregnancy among women using DHEA with the controls group.

Results

Cumulative clinical pregnancy rates were significantly higher in the study group (25 pregnancies; 28.4% vs. 11 pregnancies; 11.9%; relative hazard of pregnancy in study group (HR 3.8; 95% CI 1.2–11.8; p < 0.05).

Conclusions

DHEA treatment resulted in significantly higher cumulative pregnancy rates. These data support a beneficial effect of DHEA supplementation among women with diminished ovarian function.

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Title: Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
Authors: David Barad
Hyama Brill
Norbert Gleicher
Publication date: 01-12-2007
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 12/2007
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-007-9178-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function

Abstract

Objective

Design

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Results

Conclusions

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