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Published in: International Ophthalmology 1/2024

01-12-2024 | Original Paper

Effect of mindfulness-based stress reduction on acute central serous chorioretinopathy: a randomized control trial

Authors: Delil Özcan, Murat Karapapak

Published in: International Ophthalmology | Issue 1/2024

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Abstract

Purpose

To assess the positive effects of mindfulness-based stress reduction (MBSR) on the structural and functional outcomes of patients with central serous chorioretinopathy (CSCR).

Methods

This study included 60 patients with CSCR who were randomly allocated to one of two groups: MBSR or control (which did not practice MBSR). These groups were then evaluated in terms of best corrected visual acuity (BCVA) and central macular thickness (CMT) at months 1, 3, and 6.

Results

There were no significant differences in BCVA or mean CMT between the groups at the beginning of the study (p = 0.615 and p = 0.561, respectively). There were statistically significant differences between the groups in terms of BCVA at 1, 3, and 6 months (p = 0.018, p = 0.001, and p = 0.002, respectively). There were also significant differences in the mean CMT across the groups at the first, third, and sixth months (p < 0.001, p = 0.001, and p < 0.001, respectively).

Conclusion

MBSR may have beneficial outcomes in the early treatment of patients with CSCR, resulting in faster resolution of subretinal fluid and enhancement of BCVA.
Literature
1.
go back to reference Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N et al (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82–118CrossRefPubMed Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N et al (2015) Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res 48:82–118CrossRefPubMed
2.
go back to reference Daruich A, Matet A, Marchionno L, De Azevedo J-D, Ambresin A, Mantel I et al (2017) Acute central serous chorioretinopathy: factors influencing episode duration. Retina 37:1905–1915CrossRefPubMedPubMedCentral Daruich A, Matet A, Marchionno L, De Azevedo J-D, Ambresin A, Mantel I et al (2017) Acute central serous chorioretinopathy: factors influencing episode duration. Retina 37:1905–1915CrossRefPubMedPubMedCentral
3.
go back to reference van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO et al (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770CrossRefPubMed van Rijssen TJ, van Dijk EHC, Yzer S, Ohno-Matsui K, Keunen JEE, Schlingemann RO et al (2019) Central serous chorioretinopathy: towards an evidence-based treatment guideline. Prog Retin Eye Res 73:100770CrossRefPubMed
4.
go back to reference Erikitola OC, Crosby-Nwaobi R, Lotery AJ, Sivaprasad S (2014) Photodynamic therapy for central serous chorioretinopathy. Eye (Lond) 28:944–957CrossRefPubMed Erikitola OC, Crosby-Nwaobi R, Lotery AJ, Sivaprasad S (2014) Photodynamic therapy for central serous chorioretinopathy. Eye (Lond) 28:944–957CrossRefPubMed
5.
go back to reference Yadav NK, Jayadev C, Mohan A, Vijayan P, Battu R, Dabir S et al (2015) Subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy: Safety profile and treatment outcome. Eye 29:258–265CrossRefPubMedPubMedCentral Yadav NK, Jayadev C, Mohan A, Vijayan P, Battu R, Dabir S et al (2015) Subthreshold micropulse yellow laser (577 nm) in chronic central serous chorioretinopathy: Safety profile and treatment outcome. Eye 29:258–265CrossRefPubMedPubMedCentral
6.
go back to reference Pitcher JD 3rd, Witkin AJ, DeCroos FC, Ho AC (2015) A prospective pilot study of intravitreal aflibercept for the treatment of chronic central serous chorioretinopathy: the CONTAIN study. Br J Ophthalmol 99:848–852CrossRefPubMed Pitcher JD 3rd, Witkin AJ, DeCroos FC, Ho AC (2015) A prospective pilot study of intravitreal aflibercept for the treatment of chronic central serous chorioretinopathy: the CONTAIN study. Br J Ophthalmol 99:848–852CrossRefPubMed
7.
go back to reference Lotery A, Sivaprasad S, O’Connell A, Harris RA, Culliford L, Ellis L et al (2020) Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double blind, placebo-controlled trial. Lancet 395:294–303CrossRefPubMed Lotery A, Sivaprasad S, O’Connell A, Harris RA, Culliford L, Ellis L et al (2020) Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double blind, placebo-controlled trial. Lancet 395:294–303CrossRefPubMed
8.
go back to reference Chhablani J, Rani PK, Mathai A, Jalali S, Kozak I (2014) Navigated focal laser photocoagulation for central serous chorioretinopathy. Clin Ophthalmol 8:1543–1547CrossRefPubMedPubMedCentral Chhablani J, Rani PK, Mathai A, Jalali S, Kozak I (2014) Navigated focal laser photocoagulation for central serous chorioretinopathy. Clin Ophthalmol 8:1543–1547CrossRefPubMedPubMedCentral
10.
go back to reference Conrad R, Geiser F, Kleiman A, Zur B, Karpawitz-Godt A (2014) Temperament and character personality profile and illness-related stress in central serous chorioretinopathy. Sci World J 2014:631687CrossRef Conrad R, Geiser F, Kleiman A, Zur B, Karpawitz-Godt A (2014) Temperament and character personality profile and illness-related stress in central serous chorioretinopathy. Sci World J 2014:631687CrossRef
11.
go back to reference Nongrem G, Surve A, Venkatesh P, Sagar R, Yadav RK, Chawla R, Vohra R, Kumar A (2021Dec) Effect of short-term meditation training in central serous chorioretinopathy. Indian J Ophthalmol 69(12):3559–3563CrossRefPubMedPubMedCentral Nongrem G, Surve A, Venkatesh P, Sagar R, Yadav RK, Chawla R, Vohra R, Kumar A (2021Dec) Effect of short-term meditation training in central serous chorioretinopathy. Indian J Ophthalmol 69(12):3559–3563CrossRefPubMedPubMedCentral
12.
go back to reference Yoshioka H, Katsume Y, Akune H (1982) Experimental central serous chorioretinopathy in monkey eyes: Fluorescein angiographic findings. Ophthalmologica 185:168–178CrossRefPubMed Yoshioka H, Katsume Y, Akune H (1982) Experimental central serous chorioretinopathy in monkey eyes: Fluorescein angiographic findings. Ophthalmologica 185:168–178CrossRefPubMed
13.
go back to reference Kutz I, Borysenko JZ, Benson H (1985) Meditation and psychotherapy: a rationale for the integration of dynamic psychotherapy, the relaxation response, and mindfulness meditation. Am J Psychiatr. 142(1):1e8 Kutz I, Borysenko JZ, Benson H (1985) Meditation and psychotherapy: a rationale for the integration of dynamic psychotherapy, the relaxation response, and mindfulness meditation. Am J Psychiatr. 142(1):1e8
14.
go back to reference Gagrani M, Faiq MA, Sidhu T, Dada R, Yadav RK, Sihota R et al (2018) Meditation enhances brain oxygenation, upregulates BDNF and improves quality of life in patients with primary open angle glaucoma: A randomized controlled trial. Restor Neurol Neurosci 36:741–753PubMed Gagrani M, Faiq MA, Sidhu T, Dada R, Yadav RK, Sihota R et al (2018) Meditation enhances brain oxygenation, upregulates BDNF and improves quality of life in patients with primary open angle glaucoma: A randomized controlled trial. Restor Neurol Neurosci 36:741–753PubMed
15.
go back to reference Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK et al (2018) Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma: a randomized controlled trial. J Glaucoma 27:1061–1067CrossRefPubMed Dada T, Mittal D, Mohanty K, Faiq MA, Bhat MA, Yadav RK et al (2018) Mindfulness meditation reduces intraocular pressure, lowers stress biomarkers and modulates gene expression in glaucoma: a randomized controlled trial. J Glaucoma 27:1061–1067CrossRefPubMed
16.
go back to reference Dudani AI, Hussain N, Ramakrishnan M, Telang O, Patil VM, Dudani K, Jadhav B, Gholap V (2021) Psychiatric evaluation in patients with central serous chorioretinopathy in Asian Indians. Indian J Ophthalmol 69(5):1204–1207CrossRefPubMedPubMedCentral Dudani AI, Hussain N, Ramakrishnan M, Telang O, Patil VM, Dudani K, Jadhav B, Gholap V (2021) Psychiatric evaluation in patients with central serous chorioretinopathy in Asian Indians. Indian J Ophthalmol 69(5):1204–1207CrossRefPubMedPubMedCentral
17.
go back to reference Tekin K, Sekeroglu MA, Cankaya AB, Teke MY, Doguizi S, Yilmazbas P (2018) Intravitreal bevacizumab and ranibizumab in the treatment of acute central serous chorioretihopathy: a single center retrospective study. Semin Ophthalmol 33(2):265–270PubMed Tekin K, Sekeroglu MA, Cankaya AB, Teke MY, Doguizi S, Yilmazbas P (2018) Intravitreal bevacizumab and ranibizumab in the treatment of acute central serous chorioretihopathy: a single center retrospective study. Semin Ophthalmol 33(2):265–270PubMed
18.
go back to reference Azam MA, Katz J, Fashler SR, Changoor T, Azargive S, Ritvo P (2015) Heart rate variability is enhanced in controls but not maladaptive perfectionists during briefmindfulness meditation following stress-induction: a stratified-randomized trial. Int J Psychophysiol Off J Int Organ Psychophysiol 98(1):27–34 Azam MA, Katz J, Fashler SR, Changoor T, Azargive S, Ritvo P (2015) Heart rate variability is enhanced in controls but not maladaptive perfectionists during briefmindfulness meditation following stress-induction: a stratified-randomized trial. Int J Psychophysiol Off J Int Organ Psychophysiol 98(1):27–34
19.
go back to reference Dada T, Ramesh P, Shakrawal J (2020) Meditation: a polypill for comprehensive management of glaucoma patients. J Glaucoma 29(2):133–140CrossRefPubMed Dada T, Ramesh P, Shakrawal J (2020) Meditation: a polypill for comprehensive management of glaucoma patients. J Glaucoma 29(2):133–140CrossRefPubMed
Metadata
Title
Effect of mindfulness-based stress reduction on acute central serous chorioretinopathy: a randomized control trial
Authors
Delil Özcan
Murat Karapapak
Publication date
01-12-2024
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-03102-z

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