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01-12-2024 | Original Paper

Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?

Authors: Ariana Ringer, Andrea María Smichowski, Ramiro Gómez, Belén Virasoro, Liliana Martínez, Emmanuel Bertiller, Carlos Siegrist, Brian Abdala, Serenela Chulibert, German Grossi, Eduardo Rubín, Alex Kostianovsky, Sebastián Andrés Muñoz, Sophia Lutgen, Ignacio Javier Gandino, The Study Working Group of Rheumatological Ocular Diseases, Argentinian Society of Rheumatology.

Published in: International Ophthalmology | Issue 1/2024

Abstract

Purpose

To assess the prevalence of autoimmune diseases (ADs) associated with ocular cicatricial pemphigoid (OCP) and analyze clinical, laboratory, and treatment associations between these entities.

Methods

A multicentre cross-sectional study of patients with an OCP diagnosis. The population was divided into two groups according to their association with other ADs or not. Clinical, laboratory and treatment variables were described and compared between groups. A multivariable logistic regression analysis was performed to identify variables that could suggest the association between OCP and ADs.

Results

Eighty-eight patients were recruited, with a mean age at diagnosis of 64.3 years (SD 11.9). Biopsy was performed in 86.8% of the patients. There was a median delay of 2 years from the onset of symptoms to diagnosis. Extraocular involvement was evidenced in 11.5%. The group associated with ADs included 24 patients (27.3%). The most prevalent diagnosis was Sjögren´s syndrome. Hypergammaglobulinemia was associated with ADs and OCP, adjusted for age, sex, smoking, skin and mucosal involvement, and erythrocyte sedimentation rate (OR 8.7; 95%CI 1.6–46.8; p = 0.012).

Conclusions

Due to OCP’s autoimmune nature, it could coexist with other ADs. This study observed that more than a quarter of the population presented with this association, and hypergammaglobulinemia could suggest it.

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Title: Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?
Authors: Ariana Ringer
Andrea María Smichowski
Ramiro Gómez
Belén Virasoro
Liliana Martínez
Emmanuel Bertiller
Carlos Siegrist
Brian Abdala
Serenela Chulibert
German Grossi
Eduardo Rubín
Alex Kostianovsky
Sebastián Andrés Muñoz
Sophia Lutgen
Ignacio Javier Gandino
The Study Working Group of Rheumatological Ocular Diseases, Argentinian Society of Rheumatology.
Publication date: 01-12-2024
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-02939-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ocular cicatricial pemphigoid: is there an association with autoimmune diseases?

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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