At the beginning of the last century, a uveitis entity linked to heterochromia was identified. It was first described in 1902 by Ernst Fuchs, working in Habsburg Imperial Vienna, in these terms: “When the colours of both eyes are different, it can happen that in one of the two eyes, always in the eye with the brighter iris, a cataract develops. In addition these brighter eyes present also a chronic cyclitis with corneal keratic precipitates” [1]. This observation was published in 1902 in the 9th edition of Ernst Fuchs’ ophthalmology textbook (Fig. 1).