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01-02-2015 | Research Article

Dual inhibition of arachidonic acid pathway by mulberry leaf extract

Authors: Seema Chauhan, Uma Devi, Venkatesh R. Kumar, Vikas Kumar, Firoz Anwar, Gaurav Kaithwas

Published in: Inflammopharmacology | Issue 1/2015

Abstract

The present work investigates the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of mulberry leaves of variety S-1, S-13 and S-146. The S-146 extract was further evaluated for its efficacy against adjuvant arthritis in albino rats followed by inhibitory potential for COX 1, COX 2 and 5 LOX. The HPLC analysis enumerated the presence of morin, reversterol, scopoletin and 7-hydroxy coumarin as the major constituents. The anti-inflammatory, antipyretic and analgesic activity observed in the present experiment could be accredited to the dual inhibition in the AA pathway. The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.

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Title: Dual inhibition of arachidonic acid pathway by mulberry leaf extract
Authors: Seema Chauhan
Uma Devi
Venkatesh R. Kumar
Vikas Kumar
Firoz Anwar
Gaurav Kaithwas
Publication date: 01-02-2015
Publisher: Springer Basel
Published in: Inflammopharmacology / Issue 1/2015
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-014-0223-y

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Dual inhibition of arachidonic acid pathway by mulberry leaf extract

Abstract

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Abstract

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