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Inflammation
Published in: Inflammation 5/2017

01-10-2017 | ORIGINAL ARTICLE

Inhibition of Endoplasmic Reticulum Stress Alleviates Lung Injury Induced by Brain Death

Authors: Hongwei Tang, Jiakai Zhang, Shengli Cao, Bing Yan, Hongbo Fang, Huapeng Zhang, Wenzhi Guo, Shuijun Zhang

Published in: Inflammation | Issue 5/2017

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Abstract

Brain death (BD) can induce inflammation and injury of organs. Endoplasmic reticulum (ER) stress is associated with a variety of diseases. However, little is known about how ER stress is implicated in brain death (BD)-induced lung injury. In this study, a stable BD rat model was constructed to investigate the role of ER stress on BD-induced lung injury. H&E staining demonstrated that BD can induce lung injury in rats. The results of Western blot and immunohistochemistry showed that apoptosis was observed in the lung tissues of BD rats. And the level of GRP78, p-PERK, p-eIF2α, CHOP, and Caspase-12 was highly expressed in BD rats compared with the control group. Inhibition of ER stress with salubrinal reduced the BD-induced lung inflammation. Moreover, BD-induced increase of NF-κB activity was lowered by inhibition of ER stress. These results suggested that inhibition of ER stress alleviates BD-induced lung inflammation by regulating NF-κB signaling pathway.
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Metadata
Title
Inhibition of Endoplasmic Reticulum Stress Alleviates Lung Injury Induced by Brain Death
Authors
Hongwei Tang
Jiakai Zhang
Shengli Cao
Bing Yan
Hongbo Fang
Huapeng Zhang
Wenzhi Guo
Shuijun Zhang
Publication date
01-10-2017
Publisher
Springer US
Published in
Inflammation / Issue 5/2017
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-017-0606-5

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