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Inflammation
Published in: Inflammation 4/2014

01-08-2014

Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice

Authors: Xiaosheng Feng, Aiqing Jia

Published in: Inflammation | Issue 4/2014

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Abstract

Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-κB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-α, IL-6 and IL-1β production.
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Metadata
Title
Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice
Authors
Xiaosheng Feng
Aiqing Jia
Publication date
01-08-2014
Publisher
Springer US
Published in
Inflammation / Issue 4/2014
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-014-9833-1

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