Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Health Services and Outcomes Research Methodology
Published in: Health Services and Outcomes Research Methodology 3/2009

01-09-2009

Some methodological issues with the analysis of preference-based EQ-5D index score

Authors: Liang Li, Alex Z. Fu

Published in: Health Services and Outcomes Research Methodology | Issue 3/2009

Login to get access

Abstract

The EQ-5D index is widely used to assess the preference-based health status. In this paper, we examine the analytical issues of regression models for the US preference-based EQ-5D index score. We propose a two-part approach to model the special features of the EQ-5D index. The first part is a logistic model for the probability of reaching the maximum score 1.0. The second part is a model for the rest of the scores that are less than 1.0, which can be a least squares regression with robust standard errors for the conditional mean, or a quantile regression for conditional quantiles such as the median. We show that the two-part model has some desirable features that are not available in the previously published regression methods for the EQ-5D index. We illustrate the proposed approach with data from the Medical Expenditure Panel Survey. The proposed method may be used for other utility or health related quality of life scores of similar features.
Appendix
Available only for authorised users
Literature
Austin, P.C.: A comparison of methods for analyzing health-related quality-of-life measures. Value Health 5, 329–337 (2002)PubMedCrossRef
Austin, P.C., Escobar, M., Kopec, J.A.: The use of the tobit model for analyzing measures of health status. Qual. Life Res. 9, 901–910 (2000)PubMedCrossRef
Charlson, M.E., Pompei, P., Ales, K.L., MacKenzie, C.R.: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chron. Dis. 40, 373–383 (1987)PubMedCrossRef
Clarke, P., Gray, A., Holman, R.: Estimating utility values for health states of type 2 diabetic patients using the EQ-5D (UKPDS 62). Med. Decis. Making 22, 340–349 (2002)PubMed
Deyo, R.A., Cherkin, D.C., Ciol, M.A.: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J. Clin. Epidemiol. 45, 613–619 (1992)PubMedCrossRef
Dow, W.H., Norton, E.C.: Choosing between and interpreting the Heckit and two-part models for corner solutions. Health Serv. Outcomes Res. Methodol. 4, 5–18 (2003)CrossRef
Drummond, M.F., Sculphre, M.J., Torrance, G.W., O’Brien, B.J., Stoddart, G.L.: Methods for the Economic Evaluation of Health Care Programmes, 3 edn. Oxford University Press, Oxford (2005)
Duan, N., Manning, W.G., Morris, C.N., Newhouse, J.P.: Choosing between the sample-selection model and the multi-part model. J. Bus. Econ. Stat. 2, 283–289 (1984)CrossRef
EuroQol Group: EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 16, 199–208 (1990)CrossRef
Fryback, D.G., Dunham, N.C., Palta, M., Hanmer, J., Buechner, J., Cherepanov, D., Herrington, S.A., Hays, R.D., Kaplan, R.M., Ganiats, T.G., Feeny, D., Kind, P.: US norms for six generic health-related quality-of-life indexes from the National Health Measurement study. Med. Care 45, 1162–1170 (2007)PubMedCrossRef
Fu, A.Z., Kattan, M.W.: Racial and ethnic differences in preference-based health status measure. Curr. Med. Res. Opin. 22, 2439–2448 (2006)PubMedCrossRef
Furlong, W.J., Feeny, D.H., Torrance, G.W., Barr, R.D.: The health utilities index system for assessing health-related quality of life in clinical studies. Ann. Med. 33, 375–384 (2001)PubMedCrossRef
Greene, W.H.: Econometric Analysis, 4 edn. Prentice Hall, Upper Sadder River, NJ (2000)
Huang, I.-C., Frangakis, C., Atkinson, M.J., Willke, R.J., Leite, W.L., Vogel, W.B., Wu, A.W.: Addressing ceiling effects in health status measures: a comparison of techniques applied to measures for people with HIV disease. Health Serv. Res. 43, 327–339 (2008)PubMedCrossRef
Huber, P.J.: The behavior of maximum likelihood estimates under nonstandard conditions. Proceedings of the 5th Berkeley Symposium, vol. 1, pp. 221–233 (1967)
Kaplan, R.M., Sieber, W.J., Ganiats, T.G.: The Quality of Well-Being Scale: comparison of the interviewer-administered version with the self-administered questionnaire. Psychol. Health 12, 783–791 (1997)CrossRef
Koch, C.G., Khandwala, F., Li, L., Estafanous, F.G., Loop, F.D., Blackstone, E.H.: Persistent effect of red cell transfusion on health related quality of life after cardiac surgery. Ann. Thorac. Surg. 82, 13–20 (2006)PubMedCrossRef
Koenker, R.: Quantile Regression. Cambridge University Press, New York, NY (2005)
Leung, S.F., Yu, S.: On the choice between sample selection and two-part models. J. Econom. 72, 197–229 (1996)CrossRef
MEPS: Weights and response rates for the self-administered questionnaire. In: MEPS HC-079: 2003 Full Year Consolidated Data File, pp. c123–c124. Agency for Healthcare Research and Quality, Rockville, MD (2005)
Olsen, M.K., Schafer, J.L.: A two-part random-effects model for semicontinuous longitudinal data. J. Am. Stat. Assoc. 96, 730–745 (2001)CrossRef
Schafer, J.L.: Analysis of Incomplete Multivariate Data. Chapman & Hall/CRC, New York. (1997)
Shaw, J.W., Johnson, J.A., Coons, S.J.: US valuation of the EQ-5D health states: development and testing of the D1 valuation model. Med. Care 43, 203–220 (2005)PubMedCrossRef
Sullivan, P.W., Ghushchyan, V.: Mapping the EQ-5D index from the SF-12: US general population preferences in a nationally representative sample. Med. Decis. Making 26, 401–409 (2006)PubMedCrossRef
Sullivan, P.W., Lawrence, W.F., Ghushchyan, V.: A national catalog of preference-based scores for chronic conditions in the United States. Med. Care 43, 736–749 (2005)PubMedCrossRef
Metadata
Title
Some methodological issues with the analysis of preference-based EQ-5D index score
Authors
Liang Li
Alex Z. Fu
Publication date
01-09-2009
Publisher
Springer US
Published in
Health Services and Outcomes Research Methodology / Issue 3/2009
Print ISSN: 1387-3741
Electronic ISSN: 1572-9400
DOI
https://doi.org/10.1007/s10742-009-0053-3