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14-03-2024 | Cardiomyopathy | Review

Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry

Authors: Ravi Vazirani, Moisés Rodríguez-González, Ana Castellano-Martinez, Mireia Andrés, Aitor Uribarri, Miguel Corbí-Pascual, Fernando Alfonso, Emilia Blanco-Ponce, Carmen Lluch-Requerey, Clara Fernández-Cordón, Manuel Almendro-Delia, Oscar Vedia Cruz, Iván J. Núñez-Gil, on behalf of RETAKO Investigators

Published in: Heart Failure Reviews

Abstract

Takotsubo syndrome (TTS) in the pediatric population is an infrequent but relevant cause of morbidity and mortality, with limited studies addressing its clinical course and prognosis. We aimed to analyze the clinical features and prognosis of pediatric TTS in a nation-wide multicenter registry and considering the published literature. We included a total of 54 patients from 4 different hospitals in Spain, as well as pediatric TTS patients from the published literature. Comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between pediatric and adult population features. Patients with pediatric TTS are more commonly male and exhibit a higher prevalence of physical triggers. The left ventricular ejection fraction (LVEF) was significantly lower in the pediatric population (30.5 + 10.4 vs 36.9 + 16.9, p < 0.05), resulting in more than fivefold rates of cardiogenic shock on admission compared to the general adult TTS population (Killip IV 74.1% vs 10.5%, p < 0.001) with similar rates of death and recurrence between groups. TTS in the pediatric population presents a distinctive clinical profile, with higher prevalence of atypical symptoms and physical triggers, as well as higher rates of cardiogenic shock on admission and similar mortality and recurrence rates than those of the adult population. This study provides valuable insights into understanding pediatric TTS and underscores the necessity for further research in this age group.

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Title: Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry
Authors: Ravi Vazirani
Moisés Rodríguez-González
Ana Castellano-Martinez
Mireia Andrés
Aitor Uribarri
Miguel Corbí-Pascual
Fernando Alfonso
Emilia Blanco-Ponce
Carmen Lluch-Requerey
Clara Fernández-Cordón
Manuel Almendro-Delia
Oscar Vedia Cruz
Iván J. Núñez-Gil
on behalf of RETAKO Investigators
Publication date: 14-03-2024
Publisher: Springer US
Keywords: Cardiomyopathy
Cardiogenic Shock
Cardiogenic Shock
Shock
Shock
Published in: Heart Failure Reviews
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-024-10394-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pediatric takotsubo cardiomyopathy: A review and insights from a National Multicentric Registry

Abstract

Graphical Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Graphical Abstract

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