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Published in: Heart Failure Reviews 1/2017

01-01-2017

Left atrium: the last bulwark before overt heart failure

Authors: Matteo Cameli, Giulia Elena Mandoli, Sergio Mondillo

Published in: Heart Failure Reviews | Issue 1/2017

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Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) has emerged as an important public health issue in recent years. It represents the most common type of HF in ambulatory setting, and it has been recognized as a different entity from the reduced ejection fraction (EF) form. In HFpEF, continuous growing attention has been focused on the role of the left atrium (LA) in preserving good ventricular function and asymptomatic condition of the patient since the very first stages of diastolic dysfunction (DD). Non-invasive and complete echocardiographic evaluation of diastolic phase cannot exempt from accurately analyzed LA size, mostly LA volume, and its function, in particular LA myocardial deformation by speckle tracking echocardiography (STE). This review examines the expanding role of the LA in DD and HFpEF and the importance of its complete assessment in various settings, from diagnosis to correlation with major cardiovascular events.
Literature
1.
go back to reference Paulus WJ, Tschope C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL (2007) How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 28(20):2539–2550. doi:10.1093/eurheartj/ehm037 CrossRefPubMed Paulus WJ, Tschope C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL (2007) How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 28(20):2539–2550. doi:10.​1093/​eurheartj/​ehm037 CrossRefPubMed
2.
go back to reference Dhingra A, Garg A, Kaur S, Chopra S, Batra JS, Pandey A, Chaanine AH, Agarwal SK (2014) Epidemiology of heart failure with preserved ejection fraction. Curr Feart Fail Rep 11(4):354–365. doi:10.1007/s11897-014-0223-7 CrossRef Dhingra A, Garg A, Kaur S, Chopra S, Batra JS, Pandey A, Chaanine AH, Agarwal SK (2014) Epidemiology of heart failure with preserved ejection fraction. Curr Feart Fail Rep 11(4):354–365. doi:10.​1007/​s11897-014-0223-7 CrossRef
3.
go back to reference Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251–259. doi:10.1056/NEJMoa052256 CrossRefPubMed Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355(3):251–259. doi:10.​1056/​NEJMoa052256 CrossRefPubMed
6.
go back to reference Zile MR, Brutsaert DL (2002) New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment. Circulation 105(12):1503–1508CrossRefPubMed Zile MR, Brutsaert DL (2002) New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment. Circulation 105(12):1503–1508CrossRefPubMed
7.
go back to reference Douglas PS (2003) The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk. J Am Coll Cardiol 42(7):1206–1207CrossRefPubMed Douglas PS (2003) The left atrium: a biomarker of chronic diastolic dysfunction and cardiovascular disease risk. J Am Coll Cardiol 42(7):1206–1207CrossRefPubMed
9.
go back to reference Nagueh SF, Mikati I, Kopelen HA, Middleton KJ, Quiñones MA, Zoghbi WA (1998) Doppler estimation of left ventricular filling pressure in sinus tachycardia. A new application of tissue Doppler imaging. Circulation 98(16):1644–1650CrossRefPubMed Nagueh SF, Mikati I, Kopelen HA, Middleton KJ, Quiñones MA, Zoghbi WA (1998) Doppler estimation of left ventricular filling pressure in sinus tachycardia. A new application of tissue Doppler imaging. Circulation 98(16):1644–1650CrossRefPubMed
10.
go back to reference Hammoudi N, Achkar M, Laveau F, Boubrit L, Djebbar M, Allali Y, Komajda M, Isnard R (2014) Left atrial volume predicts abnormal exercise left ventricular filling pressure. Eur J Heart Fail 16(10):1089–1095. doi:10.1002/ejhf.131 CrossRefPubMed Hammoudi N, Achkar M, Laveau F, Boubrit L, Djebbar M, Allali Y, Komajda M, Isnard R (2014) Left atrial volume predicts abnormal exercise left ventricular filling pressure. Eur J Heart Fail 16(10):1089–1095. doi:10.​1002/​ejhf.​131 CrossRefPubMed
11.
go back to reference Wade MR, Chandraratna PA, Reid CL, Lin SL, Rahimtoola SH (1987) Accuracy of nondirected and directed M-mode echocardiography as an estimate of left atrial size. Am Jf Cardiol 60(14):1208–1211CrossRef Wade MR, Chandraratna PA, Reid CL, Lin SL, Rahimtoola SH (1987) Accuracy of nondirected and directed M-mode echocardiography as an estimate of left atrial size. Am Jf Cardiol 60(14):1208–1211CrossRef
12.
go back to reference Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28(1):1–39 e14. doi:10.1016/j.echo.2014.10.003 CrossRefPubMed Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28(1):1–39 e14. doi:10.​1016/​j.​echo.​2014.​10.​003 CrossRefPubMed
13.
go back to reference Tsang TS, Barnes ME, Gersh BJ, Bailey KR, Seward JB (2002) Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol 90(12):1284–1289CrossRefPubMed Tsang TS, Barnes ME, Gersh BJ, Bailey KR, Seward JB (2002) Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol 90(12):1284–1289CrossRefPubMed
14.
go back to reference Matsuda M, Matsuda Y (1996) Mechanism of left atrial enlargement related to ventricular diastolic impairment in hypertension. Clin Cardiol 19(12):954–959CrossRefPubMed Matsuda M, Matsuda Y (1996) Mechanism of left atrial enlargement related to ventricular diastolic impairment in hypertension. Clin Cardiol 19(12):954–959CrossRefPubMed
16.
go back to reference Ratanasit N, Karaketklang K, Chirakarnjanakorn S, Krittayaphong R, Jakrapanichakul D (2014) Left atrial volume as an independent predictor of exercise capacity in patients with isolated diastolic dysfunction presented with exertional dyspnea. Cardiovasc Ultrasound 12:19. doi:10.1186/1476-7120-12-19 CrossRefPubMedPubMedCentral Ratanasit N, Karaketklang K, Chirakarnjanakorn S, Krittayaphong R, Jakrapanichakul D (2014) Left atrial volume as an independent predictor of exercise capacity in patients with isolated diastolic dysfunction presented with exertional dyspnea. Cardiovasc Ultrasound 12:19. doi:10.​1186/​1476-7120-12-19 CrossRefPubMedPubMedCentral
18.
go back to reference Vasan RS, Larson MG, Levy D, Galderisi M, Wolf PA, Benjamin EJ, National Heart L, Blood Institute NIoH (2003) Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study). Am J Cardiol 91(9):1079–1083CrossRefPubMed Vasan RS, Larson MG, Levy D, Galderisi M, Wolf PA, Benjamin EJ, National Heart L, Blood Institute NIoH (2003) Doppler transmitral flow indexes and risk of atrial fibrillation (the Framingham Heart Study). Am J Cardiol 91(9):1079–1083CrossRefPubMed
19.
go back to reference Choong CY, Herrmann HC, Weyman AE, Fifer MA (1987) Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. J Am Coll Cardiol 10(4):800–808CrossRefPubMed Choong CY, Herrmann HC, Weyman AE, Fifer MA (1987) Preload dependence of Doppler-derived indexes of left ventricular diastolic function in humans. J Am Coll Cardiol 10(4):800–808CrossRefPubMed
20.
go back to reference Hesse B, Schuele SU, Thamilasaran M, Thomas J, Rodriguez L (2004) A rapid method to quantify left atrial contractile function: Doppler tissue imaging of the mitral annulus during atrial systole. Eur J Echocardiogr 5(1):86–92CrossRefPubMed Hesse B, Schuele SU, Thamilasaran M, Thomas J, Rodriguez L (2004) A rapid method to quantify left atrial contractile function: Doppler tissue imaging of the mitral annulus during atrial systole. Eur J Echocardiogr 5(1):86–92CrossRefPubMed
21.
go back to reference Gulel O, Yuksel S, Soylu K, Kaplan O, Yilmaz O, Kahraman H, Sahin M (2009) Evaluation of left atrial functions by color tissue Doppler imaging in adults with body mass indexes ≥30 kg/m2 versus those <30 kg/m2. Int J Cardiovasc Imaging 25(4):371–377. doi:10.1007/s10554-008-9403-4 CrossRefPubMed Gulel O, Yuksel S, Soylu K, Kaplan O, Yilmaz O, Kahraman H, Sahin M (2009) Evaluation of left atrial functions by color tissue Doppler imaging in adults with body mass indexes ≥30 kg/m2 versus those <30 kg/m2. Int J Cardiovasc Imaging 25(4):371–377. doi:10.​1007/​s10554-008-9403-4 CrossRefPubMed
22.
23.
24.
go back to reference Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr 12(3):167–205. doi:10.1093/ejechocard/jer021 CrossRefPubMed Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL (2011) Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr 12(3):167–205. doi:10.​1093/​ejechocard/​jer021 CrossRefPubMed
25.
go back to reference Saraiva RM, Demirkol S, Buakhamsri A, Greenberg N, Popović ZB, Thomas JD, Klein AL (2010) Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function. J Am Soc Echocardiogr 23(2):172–180. doi:10.1016/j.echo.2009.11.003 CrossRefPubMed Saraiva RM, Demirkol S, Buakhamsri A, Greenberg N, Popović ZB, Thomas JD, Klein AL (2010) Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function. J Am Soc Echocardiogr 23(2):172–180. doi:10.​1016/​j.​echo.​2009.​11.​003 CrossRefPubMed
26.
go back to reference Mondillo S, Cameli M, Caputo ML, Lisi M, Palmerini E, Padeletti M, Ballo P (2011) Early detection of left atrial strain abnormalities by speckle-tracking in hypertensive and diabetic patients with normal left atrial size. J Am Soc Echocardiogr 24(8):898–908. doi:10.1016/j.echo.2011.04.014 CrossRefPubMed Mondillo S, Cameli M, Caputo ML, Lisi M, Palmerini E, Padeletti M, Ballo P (2011) Early detection of left atrial strain abnormalities by speckle-tracking in hypertensive and diabetic patients with normal left atrial size. J Am Soc Echocardiogr 24(8):898–908. doi:10.​1016/​j.​echo.​2011.​04.​014 CrossRefPubMed
27.
go back to reference Cameli M, Lisi M, Righini FM, Massoni A, Natali BM, Focardi M, Tacchini D, Geyer A, Curci V, Di Tommaso C, Lisi G, Maccherini M, Chiavarelli M, Massetti M, Tanganelli P, Mondillo S (2013) Usefulness of atrial deformation analysis to predict left atrial fibrosis and endocardial thickness in patients undergoing mitral valve operations for severe mitral regurgitation secondary to mitral valve prolapse. Am J Cardiol 111(4):595–601. doi:10.1016/j.amjcard.2012.10.049 CrossRefPubMed Cameli M, Lisi M, Righini FM, Massoni A, Natali BM, Focardi M, Tacchini D, Geyer A, Curci V, Di Tommaso C, Lisi G, Maccherini M, Chiavarelli M, Massetti M, Tanganelli P, Mondillo S (2013) Usefulness of atrial deformation analysis to predict left atrial fibrosis and endocardial thickness in patients undergoing mitral valve operations for severe mitral regurgitation secondary to mitral valve prolapse. Am J Cardiol 111(4):595–601. doi:10.​1016/​j.​amjcard.​2012.​10.​049 CrossRefPubMed
28.
go back to reference Salemi VM, Rochitte CE, Shiozaki AA, Andrade JM, Parga JR, de Ávila LF, Benvenuti LA, Cestari IN, Picard MH, Kim RJ, Mady C (2011) Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. Circ Cardiovasc Imaging 4(3):304–311. doi:10.1161/CIRCIMAGING.110.950675 CrossRefPubMed Salemi VM, Rochitte CE, Shiozaki AA, Andrade JM, Parga JR, de Ávila LF, Benvenuti LA, Cestari IN, Picard MH, Kim RJ, Mady C (2011) Late gadolinium enhancement magnetic resonance imaging in the diagnosis and prognosis of endomyocardial fibrosis patients. Circ Cardiovasc Imaging 4(3):304–311. doi:10.​1161/​CIRCIMAGING.​110.​950675 CrossRefPubMed
29.
go back to reference Donal E, Lip GY, Galderisi M, Goette A, Shah D, Marwan M, Lederlin M, Mondillo S, Edvardsen T, Sitges M, Grapsa J, Garbi M, Senior R, Gimelli A, Potpara TS, Van Gelder IC, Gorenek B, Mabo P, Lancellotti P, Kuck KH, Popescu BA, Hindricks G, Habib G, Cardim NM, Cosyns B, Delgado V, Haugaa KH, Muraru D, Nieman K, Boriani G, Cohen A (2016) EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation. Eur Heart J Cardiovasc Imaging 17(4):355–383. doi:10.1093/ehjci/jev354 CrossRefPubMed Donal E, Lip GY, Galderisi M, Goette A, Shah D, Marwan M, Lederlin M, Mondillo S, Edvardsen T, Sitges M, Grapsa J, Garbi M, Senior R, Gimelli A, Potpara TS, Van Gelder IC, Gorenek B, Mabo P, Lancellotti P, Kuck KH, Popescu BA, Hindricks G, Habib G, Cardim NM, Cosyns B, Delgado V, Haugaa KH, Muraru D, Nieman K, Boriani G, Cohen A (2016) EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation. Eur Heart J Cardiovasc Imaging 17(4):355–383. doi:10.​1093/​ehjci/​jev354 CrossRefPubMed
30.
go back to reference Kuppahally SS, Akoum N, Burgon NS, Badger TJ, Kholmovski EG, Vijayakumar S, Rao SN, Blauer J, Fish EN, Dibella EV, Macleod RS, McGann C, Litwin SE, Marrouche NF (2010) Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI. Circ Cardiovasc Imaging 3(3):231–239. doi:10.1161/CIRCIMAGING.109.865683 CrossRefPubMed Kuppahally SS, Akoum N, Burgon NS, Badger TJ, Kholmovski EG, Vijayakumar S, Rao SN, Blauer J, Fish EN, Dibella EV, Macleod RS, McGann C, Litwin SE, Marrouche NF (2010) Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI. Circ Cardiovasc Imaging 3(3):231–239. doi:10.​1161/​CIRCIMAGING.​109.​865683 CrossRefPubMed
31.
go back to reference Nagueh SF, Smiseth OA, Appleton CP, Byrd BF III, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner A (2016) Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 29(4):277–314. doi:10.1016/j.echo.2016.01.011 CrossRefPubMed Nagueh SF, Smiseth OA, Appleton CP, Byrd BF III, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner A (2016) Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 29(4):277–314. doi:10.​1016/​j.​echo.​2016.​01.​011 CrossRefPubMed
32.
go back to reference Cameli M, Mandoli GE, Loiacono F, Dini FL, Henein M, Mondillo S (2015) Left atrial strain: a new parameter for assessment of left ventricular filling pressure. Heart Fail Rev. doi:10.1007/s10741-015-9520-9 Cameli M, Mandoli GE, Loiacono F, Dini FL, Henein M, Mondillo S (2015) Left atrial strain: a new parameter for assessment of left ventricular filling pressure. Heart Fail Rev. doi:10.​1007/​s10741-015-9520-9
33.
go back to reference Cameli M, Sparla S, Losito M, Righini FM, Menci D, Lisi M, D'Ascenzi F, Focardi M, Favilli R, Pierli C, Fineschi M, Mondillo S (2015) Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction. Echocardiography 33(3):398–405. doi:10.1111/echo.13094 CrossRefPubMed Cameli M, Sparla S, Losito M, Righini FM, Menci D, Lisi M, D'Ascenzi F, Focardi M, Favilli R, Pierli C, Fineschi M, Mondillo S (2015) Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction. Echocardiography 33(3):398–405. doi:10.​1111/​echo.​13094 CrossRefPubMed
34.
go back to reference Cameli M, Lisi M, Mondillo S, Padeletti M, Ballo P, Tsioulpas C, Bernazzali S, Maccherini M (2010) Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure. Cardiovasc ultrasound 8:14. doi:10.1186/1476-7120-8-14 CrossRefPubMedPubMedCentral Cameli M, Lisi M, Mondillo S, Padeletti M, Ballo P, Tsioulpas C, Bernazzali S, Maccherini M (2010) Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure. Cardiovasc ultrasound 8:14. doi:10.​1186/​1476-7120-8-14 CrossRefPubMedPubMedCentral
35.
39.
go back to reference Rossi A, Cicoira M, Florea VG, Golia G, Florea ND, Khan AA, Murray ST, Nguyen JT, O'Callaghan P, Anand IS, Coats A, Zardini P, Vassanelli C, Henein M (2006) Chronic heart failure with preserved left ventricular ejection fraction: diagnostic and prognostic value of left atrial size. Int J Cardiol 110(3):386–392. doi:10.1016/j.ijcard.2005.08.049 CrossRefPubMed Rossi A, Cicoira M, Florea VG, Golia G, Florea ND, Khan AA, Murray ST, Nguyen JT, O'Callaghan P, Anand IS, Coats A, Zardini P, Vassanelli C, Henein M (2006) Chronic heart failure with preserved left ventricular ejection fraction: diagnostic and prognostic value of left atrial size. Int J Cardiol 110(3):386–392. doi:10.​1016/​j.​ijcard.​2005.​08.​049 CrossRefPubMed
40.
go back to reference Gerdts E, Oikarinen L, Palmieri V, Otterstad JE, Wachtell K, Boman K, Dahlof B, Devereux RB, Losartan Intervention For Endpoint Reduction in Hypertension S (2002) Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. Hypertension 39(3):739–743CrossRefPubMed Gerdts E, Oikarinen L, Palmieri V, Otterstad JE, Wachtell K, Boman K, Dahlof B, Devereux RB, Losartan Intervention For Endpoint Reduction in Hypertension S (2002) Correlates of left atrial size in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. Hypertension 39(3):739–743CrossRefPubMed
41.
go back to reference Briguori C, Betocchi S, Losi MA, Manganelli F, Piscione F, Pace L, Boccalatte M, Gottilla R, Salvatore M, Chiariello M (1998) Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy. Am J Cardiol 81(2):180–187CrossRefPubMed Briguori C, Betocchi S, Losi MA, Manganelli F, Piscione F, Pace L, Boccalatte M, Gottilla R, Salvatore M, Chiariello M (1998) Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy. Am J Cardiol 81(2):180–187CrossRefPubMed
42.
go back to reference Yoshida C, Nakao S, Goda A, Naito Y, Matsumoto M, Otsuka M, Shimoshikiryo M, Eguchi A, Lee-Kawabata M, Tsujino T, Masuyama T (2009) Value of assessment of left atrial volume and diameter in patients with heart failure but with normal left ventricular ejection fraction and mitral flow velocity pattern. Eur J Echocardiogr 10(2):278–281. doi:10.1093/ejechocard/jen234 CrossRefPubMed Yoshida C, Nakao S, Goda A, Naito Y, Matsumoto M, Otsuka M, Shimoshikiryo M, Eguchi A, Lee-Kawabata M, Tsujino T, Masuyama T (2009) Value of assessment of left atrial volume and diameter in patients with heart failure but with normal left ventricular ejection fraction and mitral flow velocity pattern. Eur J Echocardiogr 10(2):278–281. doi:10.​1093/​ejechocard/​jen234 CrossRefPubMed
43.
go back to reference Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA (2006) Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study). Am J Cardiol 97(1):83–89. doi:10.1016/j.amjcard.2005.07.126 CrossRefPubMed Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA (2006) Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study). Am J Cardiol 97(1):83–89. doi:10.​1016/​j.​amjcard.​2005.​07.​126 CrossRefPubMed
44.
go back to reference Rossi A, Golia G, Gasparini G, Prioli MA, Anselmi M, Zardini P (1999) Left atrial filling volume can be used to reliably estimate the regurgitant volume in mitral regurgitation. J Am Coll Cardiol 33(1):212–217CrossRefPubMed Rossi A, Golia G, Gasparini G, Prioli MA, Anselmi M, Zardini P (1999) Left atrial filling volume can be used to reliably estimate the regurgitant volume in mitral regurgitation. J Am Coll Cardiol 33(1):212–217CrossRefPubMed
45.
go back to reference Sanfilippo AJ, Abascal VM, Sheehan M, Oertel LB, Harrigan P, Hughes RA, Weyman AE (1990) Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study. Circulation 82(3):792–797CrossRefPubMed Sanfilippo AJ, Abascal VM, Sheehan M, Oertel LB, Harrigan P, Hughes RA, Weyman AE (1990) Atrial enlargement as a consequence of atrial fibrillation. A prospective echocardiographic study. Circulation 82(3):792–797CrossRefPubMed
46.
go back to reference Hammoudi N, Charbonnier M, Levy P, Djebbar M, Stankovic Stojanovic K, Ederhy S, Girot R, Cohen A, Isnard R, Lionnet F (2015) Left atrial volume is not an index of left ventricular diastolic dysfunction in patients with sickle cell anaemia. Arch Cardiovasc Dis 108(3):156–162. doi:10.1016/j.acvd.2014.09.010 CrossRefPubMed Hammoudi N, Charbonnier M, Levy P, Djebbar M, Stankovic Stojanovic K, Ederhy S, Girot R, Cohen A, Isnard R, Lionnet F (2015) Left atrial volume is not an index of left ventricular diastolic dysfunction in patients with sickle cell anaemia. Arch Cardiovasc Dis 108(3):156–162. doi:10.​1016/​j.​acvd.​2014.​09.​010 CrossRefPubMed
47.
go back to reference Hoit BD, Shao Y, Gabel M, Walsh RA (1995) Left atrial mechanical and biochemical adaptation to pacing induced heart failure. Cardiovasc Res 29(4):469–474CrossRefPubMed Hoit BD, Shao Y, Gabel M, Walsh RA (1995) Left atrial mechanical and biochemical adaptation to pacing induced heart failure. Cardiovasc Res 29(4):469–474CrossRefPubMed
48.
go back to reference Santos AB, Kraigher-Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B, Voors AA, Lefkowitz M, Bransford T, Shi V, Packer M, McMurray JJ, Shah AM, Solomon SD, Investigators P (2014) Impaired left atrial function in heart failure with preserved ejection fraction. Eur J Heart Fail 16(10):1096–1103. doi:10.1002/ejhf.147 CrossRefPubMed Santos AB, Kraigher-Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B, Voors AA, Lefkowitz M, Bransford T, Shi V, Packer M, McMurray JJ, Shah AM, Solomon SD, Investigators P (2014) Impaired left atrial function in heart failure with preserved ejection fraction. Eur J Heart Fail 16(10):1096–1103. doi:10.​1002/​ejhf.​147 CrossRefPubMed
50.
go back to reference Rosca M, Popescu BA, Beladan CC, Calin A, Muraru D, Popa EC, Lancellotti P, Enache R, Coman IM, Jurcut R, Ghionea M, Ginghina C (2010) Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy. J Am Soc Echocardiogr 23(10):1090–1098. doi:10.1016/j.echo.2010.07.016 CrossRefPubMed Rosca M, Popescu BA, Beladan CC, Calin A, Muraru D, Popa EC, Lancellotti P, Enache R, Coman IM, Jurcut R, Ghionea M, Ginghina C (2010) Left atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy. J Am Soc Echocardiogr 23(10):1090–1098. doi:10.​1016/​j.​echo.​2010.​07.​016 CrossRefPubMed
51.
go back to reference Sanchis L, Gabrielli L, Andrea R, Falces C, Duchateau N, Perez-Villa F, Bijnens B, Sitges M (2015) Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction. Eur Heart J Cardiov Imaging 16(1):62–67. doi:10.1093/ehjci/jeu165 CrossRef Sanchis L, Gabrielli L, Andrea R, Falces C, Duchateau N, Perez-Villa F, Bijnens B, Sitges M (2015) Left atrial dysfunction relates to symptom onset in patients with heart failure and preserved left ventricular ejection fraction. Eur Heart J Cardiov Imaging 16(1):62–67. doi:10.​1093/​ehjci/​jeu165 CrossRef
52.
go back to reference Morris DA, Gailani M, Vaz Pérez A, Blaschke F, Dietz R, Haverkamp W, Ozcelik C (2011) Left atrial systolic and diastolic dysfunction in heart failure with normal left ventricular ejection fraction. J Am Soc Echocardiogr 24(6):651–662. doi:10.1016/j.echo.2011.02.004 CrossRefPubMed Morris DA, Gailani M, Vaz Pérez A, Blaschke F, Dietz R, Haverkamp W, Ozcelik C (2011) Left atrial systolic and diastolic dysfunction in heart failure with normal left ventricular ejection fraction. J Am Soc Echocardiogr 24(6):651–662. doi:10.​1016/​j.​echo.​2011.​02.​004 CrossRefPubMed
53.
go back to reference Freed BH, Daruwalla V, Cheng JY, Aguilar FG, Beussink L, Choi A, Klein DA, Dixon D, Baldridge A, Rasmussen-Torvik LJ, Maganti K, Shah SJ (2016) Prognostic utility and clinical significance of cardiac mechanics in heart failure with preserved ejection fraction: importance of left atrial strain. Circ Cardiovasc Imaging. 9(3). doi: 10.1161/CIRCIMAGING.115.003754. Freed BH, Daruwalla V, Cheng JY, Aguilar FG, Beussink L, Choi A, Klein DA, Dixon D, Baldridge A, Rasmussen-Torvik LJ, Maganti K, Shah SJ (2016) Prognostic utility and clinical significance of cardiac mechanics in heart failure with preserved ejection fraction: importance of left atrial strain. Circ Cardiovasc Imaging. 9(3). doi: 10.1161/CIRCIMAGING.115.003754.
54.
go back to reference Kurt M, Tanboga IH, Aksakal E, Kaya A, Isik T, Ekinci M, Bilen E (2012) Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters. Eur Heart J Cardiov Imaging 13(6):524–530. doi:10.1093/ejechocard/jer283 CrossRef Kurt M, Tanboga IH, Aksakal E, Kaya A, Isik T, Ekinci M, Bilen E (2012) Relation of left ventricular end-diastolic pressure and N-terminal pro-brain natriuretic peptide level with left atrial deformation parameters. Eur Heart J Cardiov Imaging 13(6):524–530. doi:10.​1093/​ejechocard/​jer283 CrossRef
56.
go back to reference Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, Gong Y, Liu PP (2006) Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 355(3):260–269. doi:10.1056/NEJMoa051530 CrossRefPubMed Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, Gong Y, Liu PP (2006) Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 355(3):260–269. doi:10.​1056/​NEJMoa051530 CrossRefPubMed
57.
go back to reference Yamaguchi K, Yoshitomi H, Ito S, Ito S, Adachi T, Sato H, Watanabe N, Kodani N, Sugamori T, Endo A, Takahashi N, Tanabe K (2014) Left atrial remodeling and recurrence of congestive heart failure in patients initially diagnosed with heart failure. Echocardiography 31(8):936–940. doi:10.1111/echo.12497 CrossRefPubMed Yamaguchi K, Yoshitomi H, Ito S, Ito S, Adachi T, Sato H, Watanabe N, Kodani N, Sugamori T, Endo A, Takahashi N, Tanabe K (2014) Left atrial remodeling and recurrence of congestive heart failure in patients initially diagnosed with heart failure. Echocardiography 31(8):936–940. doi:10.​1111/​echo.​12497 CrossRefPubMed
58.
go back to reference Ristow B, Ali S, Whooley MA, Schiller NB (2008) Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study). Am J Cardiol 102(1):70–76. doi:10.1016/j.amjcard.2008.02.099 CrossRefPubMedPubMedCentral Ristow B, Ali S, Whooley MA, Schiller NB (2008) Usefulness of left atrial volume index to predict heart failure hospitalization and mortality in ambulatory patients with coronary heart disease and comparison to left ventricular ejection fraction (from the Heart and Soul Study). Am J Cardiol 102(1):70–76. doi:10.​1016/​j.​amjcard.​2008.​02.​099 CrossRefPubMedPubMedCentral
59.
go back to reference Welles CC, Ku IA, Kwan DM, Whooley MA, Schiller NB, Turakhia MP (2012) Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol 59(7):673–680. doi:10.1016/j.jacc.2011.11.012 CrossRefPubMedPubMedCentral Welles CC, Ku IA, Kwan DM, Whooley MA, Schiller NB, Turakhia MP (2012) Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol 59(7):673–680. doi:10.​1016/​j.​jacc.​2011.​11.​012 CrossRefPubMedPubMedCentral
60.
go back to reference Rossi A, Temporelli PL, Quintana M, Dini FL, Ghio S, Hillis GS, Klein AL, Marsan NA, Prior DL, Yu CM, Poppe KK, Doughty RN, Whalley GA, Me RGEHFC (2009) Independent relationship of left atrial size and mortality in patients with heart failure: an individual patient meta-analysis of longitudinal data (MeRGE Heart Failure). Eur J Heart Fail 11(10):929–936. doi:10.1093/eurjhf/hfp112 CrossRefPubMed Rossi A, Temporelli PL, Quintana M, Dini FL, Ghio S, Hillis GS, Klein AL, Marsan NA, Prior DL, Yu CM, Poppe KK, Doughty RN, Whalley GA, Me RGEHFC (2009) Independent relationship of left atrial size and mortality in patients with heart failure: an individual patient meta-analysis of longitudinal data (MeRGE Heart Failure). Eur J Heart Fail 11(10):929–936. doi:10.​1093/​eurjhf/​hfp112 CrossRefPubMed
62.
63.
go back to reference Tamura H, Watanabe T, Nishiyama S, Sasaki S, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Kubota I (2011) Increased left atrial volume index predicts a poor prognosis in patients with heart failure. J Card Fail 17(3):210–216. doi:10.1016/j.cardfail.2010.10.006 CrossRefPubMed Tamura H, Watanabe T, Nishiyama S, Sasaki S, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Kubota I (2011) Increased left atrial volume index predicts a poor prognosis in patients with heart failure. J Card Fail 17(3):210–216. doi:10.​1016/​j.​cardfail.​2010.​10.​006 CrossRefPubMed
67.
go back to reference Grobner T (2006) Gadolinium—a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 4:1104–1108. doi:10.1093/ndt/gfk062 Grobner T (2006) Gadolinium—a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 4:1104–1108. doi:10.​1093/​ndt/​gfk062
68.
go back to reference Providencia R, Faustino A, Ferreira MJ, Goncalves L, Trigo J, Botelho A, Barra S, Boveda S (2013) Evaluation of left atrial deformation to predict left atrial stasis in patients with non-valvular atrial fibrillation—a pilot-study. Cardiovasc Ultrasound 11:44. doi:10.1186/1476-7120-11-44 CrossRefPubMedPubMedCentral Providencia R, Faustino A, Ferreira MJ, Goncalves L, Trigo J, Botelho A, Barra S, Boveda S (2013) Evaluation of left atrial deformation to predict left atrial stasis in patients with non-valvular atrial fibrillation—a pilot-study. Cardiovasc Ultrasound 11:44. doi:10.​1186/​1476-7120-11-44 CrossRefPubMedPubMedCentral
70.
go back to reference Shaikh AY, Maan A, Khan UA, Aurigemma GP, Hill JC, Kane JL, Tighe DA, Mick E, McManus DD (2012) Speckle echocardiographic left atrial strain and stiffness index as predictors of maintenance of sinus rhythm after cardioversion for atrial fibrillation: a prospective study. Cardiovasc ultrasound 10:48. doi:10.1186/1476-7120-10-48 CrossRefPubMedPubMedCentral Shaikh AY, Maan A, Khan UA, Aurigemma GP, Hill JC, Kane JL, Tighe DA, Mick E, McManus DD (2012) Speckle echocardiographic left atrial strain and stiffness index as predictors of maintenance of sinus rhythm after cardioversion for atrial fibrillation: a prospective study. Cardiovasc ultrasound 10:48. doi:10.​1186/​1476-7120-10-48 CrossRefPubMedPubMedCentral
71.
72.
go back to reference Sarvari SI, Haugaa KH, Stokke TM, Ansari HZ, Leren IS, Hegbom F, Smiseth OA, Edvardsen T (2015) Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation. Eur Heart J Cardiov Imaging. doi:10.1093/ehjci/jev185 Sarvari SI, Haugaa KH, Stokke TM, Ansari HZ, Leren IS, Hegbom F, Smiseth OA, Edvardsen T (2015) Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation. Eur Heart J Cardiov Imaging. doi:10.​1093/​ehjci/​jev185
73.
go back to reference McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Guidelines ESCCfP (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33(14):1787–1847. doi:10.1093/eurheartj/ehs104 CrossRefPubMed McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Guidelines ESCCfP (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33(14):1787–1847. doi:10.​1093/​eurheartj/​ehs104 CrossRefPubMed
Metadata
Title
Left atrium: the last bulwark before overt heart failure
Authors
Matteo Cameli
Giulia Elena Mandoli
Sergio Mondillo
Publication date
01-01-2017
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 1/2017
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-016-9589-9

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