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Published in:

01-11-2013

Idiopathic giant cell myocarditis and cardiac sarcoidosis

Authors: Lori A. Blauwet, Leslie T. Cooper

Published in: Heart Failure Reviews | Issue 6/2013

Abstract

Idiopathic giant cell myocarditis (GCM) and cardiac sarcoidosis (CS) are rare disorders that cause cardiomyopathy, often with ventricular arrhythmias or heart block. Infection, autoimmune processes, and genetics have all been implicated in the pathogenesis of these diseases, but the etiology for both diseases is likely a complex multifactorial process. Both GCM and CS are generally progressive despite treatment with standard heart failure and arrhythmia therapies. Making the diagnosis of GCM or CS on initial clinical presentation is possible in only a small percentage of patients, so myocardial tissue diagnosis is required. The use of multiple noninvasive imaging modalities may aid in diagnosis and assessment of response to treatment. Establishing the diagnosis of GCM or CS early is crucial, as tailored immunosuppressive treatment may significantly alter the clinical course of these patients. The prognosis of patients with GCM is poor, while the prognosis for patients with CS varies according to degree of left ventricular dysfunction.

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Title: Idiopathic giant cell myocarditis and cardiac sarcoidosis
Authors: Lori A. Blauwet
Leslie T. Cooper
Publication date: 01-11-2013
Publisher: Springer US
Published in: Heart Failure Reviews / Issue 6/2013
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-012-9358-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Idiopathic giant cell myocarditis and cardiac sarcoidosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Other articles of this Issue 6/2013

Foreword to special issue on “Myocarditis”

Role of cardiovascular magnetic resonance imaging (CMR) in the diagnosis of acute and chronic myocarditis

Dilated cardiomyopathy update: infectious-immune theory revisited

Classification and histological, immunohistochemical, and molecular diagnosis of inflammatory myocardial disease

The immunological axis in heart failure: importance of the leukocyte differential

Anticoagulation in heart failure: current status and future direction