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27-08-2023 | Autopsy | REVIEW

Prevalence of incidental colorectal cancer and polyps in autopsies of different populations: a systematic review with meta-regression analysis

Authors: Shuting Wang, Zhirong Yang, Feng Sha, Xingshun Qi, Zhonghu He, Chun-Ho Szeto, Zuyao Yang, Jinling Tang

Published in: European Journal of Epidemiology | Issue 9/2023

Abstract

The colorectal cancer (CRC) and polyps incidentally found in autopsies represent the lesions that have not actually caused problems throughout the lifetime and thus may not need to be removed during screening. This study aimed to investigate the prevalence of incidental CRC (iCRC) and polyps in autopsies of different populations. A systematic search was performed on 19 August 2022 to identify autopsy studies that provided data on prevalence of iCRC, adenomatous polyps, hyperplastic polyps, and/or all polyps combined. The prevalence was pooled with the random-effects model. Subgroup and multivariable meta-regression analyses were conducted to investigate the heterogeneity. Forty-three eligible studies including 59,656 autopsies were identified, with 94% conducted before 1990 when CRC screening was uncommon or not available. The pooled prevalence was 0.7% (95% confidence interval [CI], 0.3–1.2%) for iCRC, 18.4% (95% CI, 13.3–24.1%) for adenomatous polyps, 16.4% (95% CI, 8.7–25.9%) for hyperplastic polyps, 26.3% (95% CI, 15.4–38.8%) for all polyps combined, and 29.9% (95% CI, 14.8–47.6%) for iCRC plus polyps. The prevalence of iCRC was higher (1.2%) in white-predominant populations but lower (0.4%) after excluding low-quality studies. Multivariable analyses showed that the prevalence of polyps was higher in white-predominant populations and higher-quality studies, increased with age, and showed a downward trend from “before 1975” through “after 1985”. In conclusion, the prevalence of iCRC in autopsies was not low, considering the average lifetime risk of CRC, while incidental polyps were common. Both varied greatly in different populations. These findings may have implications when weighing the benefits and harms of screening.

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Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683–91. https://doi.org/10.1136/gutjnl-2015-310912.CrossRefPubMed

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. https://doi.org/10.3322/caac.21492.CrossRefPubMed

von Renteln D, Pohl H. Polyp resection - controversial Practices and unanswered questions. Clin Transl Gastroenterol. 2017;8(3):e76. https://doi.org/10.1038/ctg.2017.6.CrossRef

Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36(6):2251–70. https://doi.org/10.1002/cncr.2820360944.CrossRefPubMed

Furuya-Kanamori L, Bell KJL, Clark J, Glasziou P, Doi SAR. Prevalence of differentiated thyroid Cancer in autopsy studies over six decades: a Meta-analysis. J Clin Oncol. 2016;34(30):3672–9. https://doi.org/10.1200/JCO.2016.67.7419.CrossRefPubMed

Bell KJ, Del Mar C, Wright G, Dickinson J, Glasziou P. Prevalence of incidental prostate cancer: a systematic review of autopsy studies. Int J Cancer. 2015;137(7):1749–57. https://doi.org/10.1002/ijc.29538.CrossRefPubMedPubMedCentral

Kalager M, Wieszczy P, Lansdorp-Vogelaar I, Corley DA, Bretthauer M, Kaminski MF. Overdiagnosis in Colorectal Cancer Screening: time to Acknowledge a Blind Spot. Gastroenterology. 2018;155(3):592–5. https://doi.org/10.1053/j.gastro.2018.07.037.CrossRefPubMed

Hughes LE. The incidence of benign and malignant neoplasms of the colon and rectum: a post-mortem study. Aust N Z J Surg. 1968;38(1):30–5.CrossRefPubMed

Coode PE, Chan KW, Chan YT. Polyps and diverticula of the large intestine: a necropsy survey in Hong Kong. Gut. 1985;26(10):1045–8. https://doi.org/10.1136/gut.26.10.1045.CrossRefPubMedPubMedCentral

10.

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535.CrossRefPubMedPubMedCentral

11.

Markowitz AJ, Winawer SJ. Management of colorectal polyps. CA Cancer J Clin. 1997;47(2):93–112. https://doi.org/10.3322/canjclin.47.2.93.CrossRefPubMed

12.

Hoy D, Brooks P, Woolf A, et al. Assessing risk of bias in prevalence studies: modification of an existing tool and evidence of interrater agreement. J Clin Epidemiol. 2012;65(9):934–9. https://doi.org/10.1016/j.jclinepi.2011.11.014.CrossRefPubMed

13.

Barendregt JJ, Doi SA, Lee YY, Norman RE, Vos T. Meta-analysis of prevalence. J Epidemiol Community Health. 2013;67(11):974–8. https://doi.org/10.1136/jech-2013-203104.CrossRefPubMed

14.

Schwarzer G, Chemaitelly H, Abu-Raddad LJ, Rücker G. Seriously misleading results using inverse of Freeman‐Tukey double arcsine transformation in meta‐analysis of single proportions. Res Synthesis Methods. 2019;10(3):476–83. https://doi.org/10.1002/jrsm.1348.CrossRef

15.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60. https://doi.org/10.1136/bmj.327.7414.557.CrossRefPubMedPubMedCentral

16.

Viechtbauer W. Meta-Analysis via Multivariate/Multilevel Linear (Mixed-Effects) Models. https://cran.r-project.org/web/packages/metafor/metafor.pdf Accessed 1 March 2021.

17.

Van den Noortgate W, López-López JA, Marín-Martínez F, Sánchez-Meca J. Three-level meta-analysis of dependent effect sizes. Behav Res Methods. 2013;45(2):576–94. https://doi.org/10.3758/s13428-012-0261-6.CrossRefPubMed

18.

Thomas ET, Del Mar C, Glasziou P, Wright G, Barratt A, Bell KJL. Prevalence of incidental breast cancer and precursor lesions in autopsy studies: a systematic review and meta-analysis. BMC Cancer. 2017;17(1):808. https://doi.org/10.1186/s12885-017-3808-1.CrossRefPubMedPubMedCentral

19.

Balduzzi S, Rücker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Mental Health. 2019;22(4):153–60. https://doi.org/10.1136/ebmental-2019-300117.CrossRef

20.

Viechtbauer W. Conducting Meta-analyses in R with the metafor Package. J Stat Softw. 2010;36(3):1–48. https://doi.org/10.18637/jss.v036.i03.CrossRef

21.

Pendergrass CJ, Edelstein DL, Hylind LM, et al. Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study. Clin Gastroenterol Hepatol. 2008;6(9):1011–5. https://doi.org/10.1016/j.cgh.2008.03.022.CrossRefPubMedPubMedCentral

22.

Paspatis GA, Papanikolaou N, Zois E, Michalodimitrakis E. Prevalence of polyps and diverticulosis of the large bowel in the Cretan population. An autopsy study. Int J Colorectal Dis. 2001;16(4):257–61. https://doi.org/10.1007/s003840100304.CrossRefPubMed

23.

Jass JR, Young PJ, Robinson EM. Predictors of presence, multiplicity, size and dysplasia of colorectal adenomas. A necropsy study in New Zealand. Gut. 1992;33(11):1508–14. https://doi.org/10.1136/gut.33.11.1508.CrossRefPubMedPubMedCentral

24.

Cajucom CC, Barrios GG, Cruz L, Varin C, Herrera L. Prevalence of colorectal polyps in Filipinos. Dis Colon Rectum. 1992;35(7):676–80. https://doi.org/10.1007/BF02053759.CrossRefPubMed

25.

Szczepanski W, Urban A, Wierzchowski W. Colorectal polyps in autopsy material. Part I. adenomatous polyps. Patologia polska. 1992;43 3:79–85.

26.

Offerhaus GJ, Giardiello FM, Tersmette KW, et al. Ethnic differences in the anatomical location of colorectal adenomatous polyps. Int J Cancer. 1991;49(5):641–4. https://doi.org/10.1002/ijc.2910490502.CrossRefPubMed

27.

Chávez-Macías LG, Jessurun J, Méndez Sánchez N. [Prevalence of adenomatous and hyperplastic polyps of the colon in the population of the General Hospital of Mexico. An autopsy study]. Rev Invest Clin. 1990;42(3):193–7.PubMed

28.

Johannsen LG, Momsen O, Jacobsen NO. Polyps of the large intestine in Aarhus, Denmark. An autopsy study. Scand J Gastroenterol. 1989;24(7):799–806. https://doi.org/10.3109/00365528909089217.CrossRefPubMed

29.

Lee YS. Incidental carcinoma of the colorectum at autopsy and its effects on the incidence and future trends of colorectal cancers in Singapore. Cancer. 1988;61(5):1059–64. https://doi.org/10.1002/1097-0142(19880301)61:5<1059::aid-cncr2820610535>3.0.co;2-f.CrossRefPubMed

30.

Bombi JA. Polyps of the colon in barcelona, Spain. An autopsy study. Cancer. 1988;61(7):1472–6. https://doi.org/10.1002/1097-0142(19880401)61:7<1472::AID-CNCR2820610734>3.0.CO;2-E.CrossRefPubMed

31.

Gerharz CD, Gabbert H, Krummel F. Age-dependent shift-to-the-right in the localization of colorectal adenomas. Virchows Arch A Pathol Anat Histopathol. 1987;411(6):591–8. https://doi.org/10.1007/bf00713291.CrossRefPubMed

32.

Lee YS. Adenomas, metaplastic polyps and other lesions of the large bowel: an autopsy survey. Ann Acad Med Singap. 1987;16(3):412–20.PubMed

33.

Clark JC, Collan Y, Eide TJ, et al. Prevalence of polyps in an autopsy series from areas with varying incidence of large-bowel cancer. Int J Cancer. 1985;36(2):179–86. https://doi.org/10.1002/ijc.2910360209.CrossRefPubMed

34.

Vatn MH, Stalsberg H. The prevalence of polyps of the large intestine in Oslo: an autopsy study. Cancer. 1982;49(4):819–25. https://doi.org/10.1002/1097-0142(19820215)49:4<819::aid-cncr2820490435>3.0.co;2-d.CrossRefPubMed

35.

Correa P, Strong JP, Johnson WD, Pizzolato P, Haenszel W. Atherosclerosis and polyps of the colon. Quantification of precursors of coronary heart disease and colon cancer. J Chronic Dis. 1982;35(5):313–20. https://doi.org/10.1016/0021-9681(82)90002-9.CrossRefPubMed

36.

Restrepo C, Correa P, Duque E, Cuello C. Polyps in a low-risk colonic cancer population in Colombia, South America. Dis Colon Rectum. 1981;24(1):29–36. https://doi.org/10.1007/BF02603446.CrossRefPubMed

37.

Marigo C, Correa P, Haenszel W. Cancer and “cancer related” colorectal lesions in São Paulo, Brazil. Int J Cancer. 1978;22(6):645–54. https://doi.org/10.1002/ijc.2910220602.CrossRefPubMed

38.

Haghighi P, Nasr K, Mohallatee EA, et al. Colorectal polyps and carcinoma in Southern Iran. Cancer. 1977;39(1):274–8. https://doi.org/10.1002/1097-0142(197701)39:1<274::aid-cncr2820390142>3.0.co;2-1.CrossRefPubMed

39.

Sato E, Ouchi A, Sasano N, Ishidate T. Polyps and diverticulosis of large bowel in autopsy population of Akita prefecture, compared with Miyagi. High risk for colorectal cancer. in Japan Cancer. 1976;37(3):1316–21. https://doi.org/10.1002/1097-0142(197603)37:3<1316::aid-cncr2820370312>3.0.co;2-#.CrossRefPubMed

40.

Sato E. Adenomatous polyps of large intestine in autopsy and surgical material. Gan. 1974;65(4):295–306.PubMed

41.

Stemmermann GN, Yatani R. Diverticulosis and polyps of the large intestine. A necropsy study of Hawaii Japanese. Cancer. 1973;31(5):1260–70. https://doi.org/10.1002/1097-0142(197305)31:5<1260::aid-cncr2820310535>3.0.co;2-n.CrossRefPubMed

42.

Correa P, Duque E, Cuello C, Haenszel W. Polyps of the colon and rectum in Cali, Colombia. Int J Cancer. 1972;9(1):86–96. https://doi.org/10.1002/ijc.2910090111.CrossRefPubMed

43.

Stemmermann GN. Cancer of the colon and rectum discovered at autopsy in hawaiian japanese. Cancer. 1966;19(11):1567–72. https://doi.org/10.1002/1097-0142(196611)19:11<1567::aid-cncr2820191118>3.0.co;2-a.CrossRefPubMed

44.

Williams AR, Balasooriya BA, Day DW. Polyps and cancer of the large bowel: a necropsy study in Liverpool. Gut. 1982;23(10):835–42. https://doi.org/10.1136/gut.23.10.835.CrossRefPubMedPubMedCentral

45.

Rickert RR, Auerbach O, Garfinkel L, Hammond EC, Frasca JM. Adenomatous lesions of the large bowel: an autopsy survey. Cancer. 1979;43(5):1847–57. https://doi.org/10.1002/1097-0142(197905)43:5<1847::aid-cncr2820430538>3.0.co;2-l.CrossRefPubMed

46.

Bremner CG, Ackerman LV. Polyps and carcinoma of the large bowel in the south african Bantu. Cancer. 1970;26(5):991–9. https://doi.org/10.1002/1097-0142(197011)26:5<991::aid-cncr2820260505>3.0.co;2-j.CrossRefPubMed

47.

Chapman I. Adenomatous polypi of large intestine: incidence and distribution. Ann Surg. 1963;157(2):223–6. https://doi.org/10.1097/00000658-196302000-00007.CrossRefPubMedPubMedCentral

48.

Arminski TC, McLean DW. Incidence and distribution of adenomatous polyps of the colon and rectum based on 1,000 autopsy examinations. Dis Colon Rectum. 1964;7:249–61. https://doi.org/10.1007/bf02630528.CrossRefPubMed

49.

Blatt LJ. Polyps of the colon and rectum. Dis Colon Rectum. 1961;4(4):277–82. https://doi.org/10.1007/BF02616606.CrossRef

50.

Cottet V, Jooste V, Bouvier AM, Michiels C, Faivre J, Bonithon-Kopp C. Time trends in first-diagnosis rates of colorectal adenomas: a 24-year population-based study. Aliment Pharmacol Ther. 2008;27(10):950–9. https://doi.org/10.1111/j.1365-2036.2008.03675.x.CrossRefPubMed

51.

Stemmermann GN, Heilbrun LK, Nomura A, Yano K, Hayashi T. Adenomatous polyps and atherosclerosis: an autopsy study of japanese men in Hawaii. Int J Cancer. 1986;38(6):789–94. https://doi.org/10.1002/ijc.2910380602.CrossRefPubMed

52.

Susman W. Polypi coli. J Pathol Bacteriol. 1932;35(1):29–33.CrossRef

53.

Helwig EB. Benign tumors of the large intestine. Surg Gynecol Obstet. 1943;76:419–26.

54.

Helwig EB. The evolution of adenomas of the large intestine and their relation to carcinoma. Surg Gynecol Obstet. 1947;84(1):36–49.PubMed

55.

Atwater JS, Bargen J. The pathogenesis of intestinal polyps. Gastroenterology. 1945;4(5):395–408.

56.

Ekelund G. On cancer and polyps of colon and rectum. Acta Pathol Microbiol Scand. 1963;59:165–70. https://doi.org/10.1111/j.1699-0463.1963.tb01783.x.CrossRefPubMed

57.

Berg JW, Downing A, Lukes RJ. Prevalence of undiagnosed cancer of the large bowel found at autopsy in different races. Cancer. 1970;25(5):1076–80. https://doi.org/10.1002/1097-0142(197005)25:5<1076::aid-cncr2820250511>3.0.co;2-l.CrossRefPubMed

58.

Graversen H, Blaakaer J. The prevalence of colorectal adenomas-an autopsy study from Denmark. Scandinavian Journal of Gastroenterology; 1986.

59.

Michiels C. Prevalence des adenomes colorectaux dans le departement de la Cote d’Or: Resultats d’une serie autopsique. 1991.

60.

Correa P, Strong JP, Reif A, Johnson WD. The epidemiology of colorectal polyps: prevalence in New Orleans and international comparisons. Cancer. 1977;39(5):2258–64. https://doi.org/10.1002/1097-0142(197705)39:5<2258::aid-cncr2820390545>3.0.co;2-s.CrossRefPubMed

61.

Arthur JF. Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol. 1968;21(6):735–43. https://doi.org/10.1136/jcp.21.6.735.CrossRefPubMedPubMedCentral

62.

Lawrence JC. Gastrointestinal polyps: statistical study of malignancy incidence. Am J Surg. 1936;31(3):499–536. https://doi.org/10.1016/S0002-9610(36)80014-2.CrossRef

63.

Magaki S, Yong WH, Khanlou N, Tung S, Vinters HV. Comorbidity in dementia: update of an ongoing autopsy study. J Am Geriatr Soc. 2014.

64.

World Bank. World Development Report 1978. https://openknowledge.worldbank.org/handle/10986/5961. Accessed August 24 2021.

65.

World Bank. World Development Report 1980. http://documents.worldbank.org/curated/en/430051469672162445/World-development-report-1980. Accessed August 24 2021.

66.

World Bank. World Development Report 1985. https://openknowledge.worldbank.org/handle/10986/5968. Accessed August 24 2021.

67.

United Nations Development Programme. Human Development Report 1990. http://hdr.undp.org/sites/default/files/reports/219/hdr_1990_en_complete_nostats.pdf. Accessed August 24 2021.

68.

Davidson KW, Barry MJ, Mangione CM, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;325(19):1965–77. https://doi.org/10.1001/jama.2021.6238.CrossRefPubMed

69.

El Halabi J, Burke CA, Hariri E, et al. Frequency of Use and Outcomes of Colonoscopy in individuals older Than 75 years. JAMA Intern Med. 2023. https://doi.org/10.1001/jamainternmed.2023.0435.CrossRefPubMed

70.

Schreuders EH, Ruco A, Rabeneck L, et al. Colorectal cancer screening: a global overview of existing programmes. Gut. 2015;64(10):1637–49. https://doi.org/10.1136/gutjnl-2014-309086.CrossRefPubMed

71.

Welch HG, Robertson DJ. Colorectal Cancer on the decline–why screening can’t explain it all. N Engl J Med. 2016;374(17):1605–7. https://doi.org/10.1056/NEJMp1600448.CrossRefPubMed

72.

Siegel RL, Fedewa SA, Anderson WF, et al. Colorectal Cancer incidence patterns in the United States, 1974–2013. J Natl Cancer Inst. 2017;109(8). https://doi.org/10.1093/jnci/djw322.

73.

Screening for colorectal cancer: U.S. Preventive services Task Force recommendation statement. Ann Intern Med. 2008;149(9):627–37. https://doi.org/10.7326/0003-4819-149-9-200811040-00243.CrossRef

74.

Hofstad B, Vatn M. Growth rate of Colon polyps and Cancer. Gastrointest Endosc Clin N Am. 1997;7(3):345–63. https://doi.org/10.1016/s1052-5157(18)30292-7.CrossRefPubMed

75.

Brenner H, Stock C, Hoffmeister M. Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies. BMJ. 2014;348:g2467. https://doi.org/10.1136/bmj.g2467.CrossRefPubMedPubMedCentral

76.

Winawer SJ, Zauber AG, Ho MN, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329(27):1977–81. https://doi.org/10.1056/nejm199312303292701.CrossRefPubMed

77.

Edwards BK, Ward E, Kohler BA, et al. Annual report to the nation on the status of cancer, 1975–2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer. 2010;116(3):544–73. https://doi.org/10.1002/cncr.24760.CrossRefPubMed

78.

Doubeni CA, Corley DA, Quinn VP, et al. Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study. Gut. 2018;67(2):291–8. https://doi.org/10.1136/gutjnl-2016-312712.CrossRefPubMed

79.

Hewitson P, Glasziou P, Watson E, Towler B, Irwig L. Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. Am J Gastroenterol. 2008;103(6):1541–9. https://doi.org/10.1111/j.1572-0241.2008.01875.x.CrossRefPubMed

80.

Littlejohn C, Hilton S, Macfarlane GJ, Phull P. Systematic review and meta-analysis of the evidence for flexible sigmoidoscopy as a screening method for the prevention of colorectal cancer. Br J Surg. 2012;99(11):1488–500. https://doi.org/10.1002/bjs.8882.CrossRefPubMed

81.

Bretthauer M, Løberg M, Wieszczy P, et al. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and related death. N Engl J Med. 2022. https://doi.org/10.1056/NEJMoa2208375.CrossRefPubMed

82.

Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB. Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology. 2008;134(2):388–95. https://doi.org/10.1053/j.gastro.2007.11.007.CrossRefPubMed

83.

Chao A, Thun MJ, Jacobs EJ, Henley SJ, Rodriguez C, Calle EE. Cigarette smoking and colorectal cancer mortality in the cancer prevention study II. J Natl Cancer Inst. 2000;92(23):1888–96. https://doi.org/10.1093/jnci/92.23.1888.CrossRefPubMed

84.

Giovannucci E. An updated review of the epidemiological evidence that cigarette smoking increases risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001;10(7):725–31.PubMed

85.

Paskett ED, Reeves KW, Rohan TE, et al. Association between cigarette smoking and colorectal cancer in the women’s Health Initiative. J Natl Cancer Inst. 2007;99(22):1729–35. https://doi.org/10.1093/jnci/djm176.CrossRefPubMed

86.

American Lung Association. Overall Tobacco Trends. https://www.lung.org/research/trends-in-lung-disease/tobacco-trends-brief/overall-tobacco-trends. Accessed Aug 25 2021.

87.

Bujanda L, Cosme A, Gil I, Arenas-Mirave JI. Malignant colorectal polyps. World J Gastroenterol. 2010;16(25):3103–11. https://doi.org/10.3748/wjg.v16.i25.3103.CrossRefPubMedPubMedCentral

88.

National Cancer Institute. Surveillance, Epidemiology, and End Results Program. https://seer.cancer.gov/statfacts/html/colorect.html. Accessed March 6 2021.

89.

Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020. CA: A Cancer. J Clin. 2020;70(3):145–64. https://doi.org/10.3322/caac.21601.CrossRef

90.

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.CrossRefPubMed

91.

Meester RG, Doubeni CA, Zauber AG, et al. Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018. Cancer. 2015;121(13):2281–5. https://doi.org/10.1002/cncr.29336.CrossRefPubMed

Title: Prevalence of incidental colorectal cancer and polyps in autopsies of different populations: a systematic review with meta-regression analysis
Authors: Shuting Wang
Zhirong Yang
Feng Sha
Xingshun Qi
Zhonghu He
Chun-Ho Szeto
Zuyao Yang
Jinling Tang
Publication date: 27-08-2023
Publisher: Springer Netherlands
Keywords: Autopsy
Colorectal Cancer
Colorectal Cancer
Published in: European Journal of Epidemiology / Issue 9/2023
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-023-01041-0

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Prevalence of incidental colorectal cancer and polyps in autopsies of different populations: a systematic review with meta-regression analysis

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