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Open Access 01-09-2020 | NEURO-EPIDEMIOLOGY

Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study

Authors: Marzieh Araghi, Martin J. Shipley, Ian B. Wilkinson, Carmel M. McEniery, Carlos A. Valencia-Hernández, Mika Kivimaki, Séverine Sabia, Archana Singh-Manoux, Eric J. Brunner

Published in: European Journal of Epidemiology | Issue 9/2020

Abstract

Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4300 participants (mean ± standard deviation age 65.1 ± 5.2 years) in 2007–2009 and categorized based on the tertiles: (lowest third: < 7.41 m/s), (middle third: 7.41–8.91 m/s), and (highest third: > 8.91 m/s). A global cognitive score was calculated in 2007–2009, 2012–2013, and 2015–2016 based on responses to memory, reasoning and fluency tests. Standardized global cognitive score (mean = 0, SD = 1) in highest third versus lowest third of PWV category was lower at baseline (− 0.12, 95% CI − 0.18, − 0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third versus lowest third PWV: − 0.06, 95% CI − 0.11, − 0.01, P < 0.01]. Higher aortic stiffness was associated with faster cognitive decline. Clinicians may be able to use arterial stiffness severity as an indicator to administer prompt treatments to prevent or delay the onset of cognitive decline or dementia. Future studies need to determine whether early intervention of vascular stiffness is effective in delaying these outcomes.

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Title: Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study
Authors: Marzieh Araghi
Martin J. Shipley
Ian B. Wilkinson
Carmel M. McEniery
Carlos A. Valencia-Hernández
Mika Kivimaki
Séverine Sabia
Archana Singh-Manoux
Eric J. Brunner
Publication date: 01-09-2020
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 9/2020
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-019-00586-3

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Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study

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