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01-07-2015 | META-ANALYSIS

Physical activity and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis

Authors: Dagfinn Aune, Teresa Norat, Michael Leitzmann, Serena Tonstad, Lars Johan Vatten

Published in: European Journal of Epidemiology | Issue 7/2015

Abstract

We investigated the association between specific types of physical activity and the risk of type 2 diabetes in a systematic review and meta-analysis of published studies. PubMed, Embase and Ovid databases were searched for prospective studies and randomized trials up to 2nd of March 2015. Summary relative risks (RRs) were calculated using a random effects model. Eighty-one studies were included. The summary RRs for high versus low activity were 0.65 (95 % CI 0.59–0.71, I² = 18 %, n = 14) for total physical activity, 0.74 (95 % CI 0.70–0.79, I² = 84 %, n = 55) for leisure-time activity, 0.61 (95 % CI 0.51–0.74, I² = 73 %, n = 8) for vigorous activity, 0.68 (95 % CI 0.52–0.90, I² = 93 %, n = 5) for moderate activity, 0.66 (95 % CI 0.47–0.94, I² = 47 %, n = 4) for low intensity activity, and 0.85 (95 % CI 0.79–0.91, I² = 0 %, n = 7) for walking. Inverse associations were also observed for increasing activity over time, resistance exercise, occupational activity and for cardiorespiratory fitness. Nonlinear relations were observed for leisure-time activity, vigorous activity, walking and resistance exercise (p _nonlinearity < 0.0001 for all), with steeper reductions in type 2 diabetes risk at low activity levels than high activity levels. This meta-analysis provides strong evidence for an inverse association between physical activity and risk of type 2 diabetes, which may partly be mediated by reduced adiposity. All subtypes of physical activity appear to be beneficial. Reductions in risk are observed up to 5–7 h of leisure-time, vigorous or low intensity physical activity per week, but further reductions cannot be excluded beyond this range.

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Title: Physical activity and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis
Authors: Dagfinn Aune
Teresa Norat
Michael Leitzmann
Serena Tonstad
Lars Johan Vatten
Publication date: 01-07-2015
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 7/2015
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-015-0056-z

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Physical activity and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis

Abstract

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Abstract

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