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European Journal of Epidemiology
Published in: European Journal of Epidemiology 6/2013

01-06-2013 | NEW STUDY

The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection

Authors: Renée de Mutsert, Martin den Heijer, Ton Johannes Rabelink, Johannes Willem Adriaan Smit, Johannes Anthonius Romijn, Johan Wouter Jukema, Albert de Roos, Christa Maria Cobbaert, Margreet Kloppenburg, Saskia le Cessie, Saskia Middeldorp, Frits Richard Rosendaal

Published in: European Journal of Epidemiology | Issue 6/2013

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Abstract

Obesity is a well-established risk factor for many chronic diseases. Incomplete insight exists in the causal pathways responsible for obesity-related disorders and consequently, in the identification of obese individuals at risk of these disorders. The Netherlands Epidemiology of Obesity (NEO) study is designed for extensive phenotyping to investigate pathways that lead to obesity-related diseases. The NEO study is a population-based, prospective cohort study that includes 6,673 individuals aged 45–65 years, with an oversampling of individuals with overweight or obesity. At baseline, data on demography, lifestyle, and medical history have been collected by questionnaires. In addition, samples of 24-h urine, fasting and postprandial blood plasma and serum, and DNA were collected. Participants underwent an extensive physical examination, including anthropometry, electrocardiography, spirometry, and measurement of the carotid artery intima-media thickness by ultrasonography. In random subsamples of participants, magnetic resonance imaging of abdominal fat, pulse wave velocity of the aorta, heart, and brain, magnetic resonance spectroscopy of the liver, indirect calorimetry, dual-energy X-ray absorptiometry, or accelerometry measurements were performed. The collection of data started in September 2008 and completed at the end of September 2012. Participants are followed for the incidence of obesity-related diseases and mortality. The NEO study investigates pathways that lead to obesity-related diseases. A better understanding of the mechanisms underlying the development of disease in obesity may help to identify individuals who are susceptible to the detrimental metabolic, cardiovascular and other consequences of obesity and has implications for the development of prevention and treatment strategies.
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Metadata
Title
The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection
Authors
Renée de Mutsert
Martin den Heijer
Ton Johannes Rabelink
Johannes Willem Adriaan Smit
Johannes Anthonius Romijn
Johan Wouter Jukema
Albert de Roos
Christa Maria Cobbaert
Margreet Kloppenburg
Saskia le Cessie
Saskia Middeldorp
Frits Richard Rosendaal
Publication date
01-06-2013
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 6/2013
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-013-9801-3

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