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01-08-2007 | Original Paper

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families

Authors: Yan-Jun Yang, Yan-Bo Wang, Shu-Feng Lei, Ji-Rong Long, Hui Shen, Lan-Juan Zhao, De-Ke Jiang, Su-Mei Xiao, Xiang-Ding Chen, Yuan Chen, Hong-Wen Deng

Published in: European Journal of Epidemiology | Issue 8/2007

Abstract

Purpose

To investigate the role of alpha2–HS glycoprotein (AHSG) gene on bone mineral density (BMD) variation.

Methods

A total of 665 subjects from 157 Caucasian nuclear families were genotyped at the AHSG NlaIII, SacI sites. The association and linkage between the single SNP markers and haplotypes constructed by two markers in this gene and BMDs at the spine and hip were determined by using quantitative transmission disequilibrium test (QTDT).

Results

Significant within-family associations were obtained for spine BMD at both of studied markers (P = 0.036 and 0.005 at the NlaIII and SacI sites, respectively). Significant (P = 0.008 at the NlaIII locus) (P = 0.004 at the SacI locus) total associations at spine BMD were detected. Haplotype analyses confirmed those within-family and total association.

Conclusions

These data suggest the polymorphisms in the AHSG gene may have effects on BMD variation in Caucasian population.

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Title: AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families
Authors: Yan-Jun Yang
Yan-Bo Wang
Shu-Feng Lei
Ji-Rong Long
Hui Shen
Lan-Juan Zhao
De-Ke Jiang
Su-Mei Xiao
Xiang-Ding Chen
Yuan Chen
Hong-Wen Deng
Publication date: 01-08-2007
Publisher: Springer Netherlands
Published in: European Journal of Epidemiology / Issue 8/2007
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-007-9140-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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