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01-08-2014 | SHORT REPORT

Kidney injuries related to ipilimumab

Authors: Hassane Izzedine, Victor Gueutin, Chems Gharbi, Christine Mateus, Caroline Robert, Emilie Routier, Marina Thomas, Alain Baumelou, Philippe Rouvier

Published in: Investigational New Drugs | Issue 4/2014

Summary

Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) have been investigated in metastatic melanoma and other cancers and have shown promising results. Inhibition of CTLA-4 characteristically induces well-known side effects called “immune-related adverse events” (irAEs). IrAEs mainly include colitis, dermatitis, hepatitis, endocrinopathies; uveitis, iridocyclitis, neuropathies, and inflammatory myopathy have occasionally been reported. Kidney involvement is rare. We report 2 cases of acute granulomatous interstitial nephritis and present, based on literature review, renal disorders related to Ipilimumab therapy. Autoimmune symptoms have to be carefully checked for patients treated with CTLA-4 inhibitors. In order to reduce the risk of sequelae, early recognition of irAEs and treatment initiation are crucial.

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Title: Kidney injuries related to ipilimumab
Authors: Hassane Izzedine
Victor Gueutin
Chems Gharbi
Christine Mateus
Caroline Robert
Emilie Routier
Marina Thomas
Alain Baumelou
Philippe Rouvier
Publication date: 01-08-2014
Publisher: Springer US
Published in: Investigational New Drugs / Issue 4/2014
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-014-0092-7

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