Published in:
Open Access
01-06-2013 | Clinical Case Report
Topical dorzolamide treatment of macular cysts in the enhanced S-cone syndrome patient
Authors:
Marta Kiszkielis, Wojciech Lubiński, Krzysztof Penkala
Published in:
Documenta Ophthalmologica
|
Issue 3/2013
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Abstract
Purpose
The purpose of the study was to evaluate the efficacy of a topical form of a carbonic anhydrase inhibitor (dorzolamide) on the foveal function and thickness in the eye of a patient with enhanced S-cone syndrome (ESCS) associated with macular cysts.
Methods
Twenty-eight-year-old Polish man with ESCS and macular cysts appearance in the right eye was treated 3 times daily with 2.0 % dorzolamide drops for the period time equal to 6 months. Monthly controls included: best corrected distance visual acuity (BCDVA-logMAR), foveal thickness (optical coherence tomography, OCT) and foveal function (multi-focal electroretinography, mfERG).
Results
Before treatment, BCDVA in the right eye was equal to 0.26 logMAR, improved to 0.1 logMAR during the first 3 months and remained stable for the next 3 months. After 6 months, foveal thickness decreased (from 482 to 224 μm) and foveal function improved (the amplitude of P1-wave density increased from 34.8 to 107.3 nV/deg2) and was between the ranges of normal values. Implicit time of P1-wave remained prolonged.
Conclusions
The results of our short-term study suggest potential efficacy of topical dorzolamide treatment in ESCS patients with macular cysts.