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01-09-2006 | ORIGINAL PAPER

Light and alcohol evoked electro-oculograms in cystic fibrosis

Authors: Paul A. Constable, John G. Lawrenson, Geoffrey B. Arden

Published in: Documenta Ophthalmologica | Issue 2/2006

Abstract

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) which is a chloride channel. CFTR is expressed in the retinal pigment epithelium (RPE) where it is believed to be important in generating the fast oscillations (FOs) and potentially contributing to the light-electro-oculogram (EOG). The role of CFTR in the alcohol-EOG is unknown. We recruited six individuals with CF (three homozygotes for Δ508 and three heterozygous for Δ508) and recorded the light- and alcohol-EOGs as well as the FOs and compared them to a control group. The results showed that in the CF group the amplitude of the alcohol- and light-EOGs were normal. However, the time to peak of the light- and alcohol-rises were significantly faster than in the control group. We conclude that CFTR is not primarily responsible for the alcohol- or light-rises but is involved in altering the timing of these responses. The FOs showed differences between the homozygotes, heterozygotes and the controls. The amplitudes were significantly higher and the time to the dark troughs were significantly slower in the heterozygote group compared to both controls and the homozygotes. In contrast, the homozygotes did not differ in either amplitude or the timing of the FOs compared to the controls.

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Title: Light and alcohol evoked electro-oculograms in cystic fibrosis
Authors: Paul A. Constable
John G. Lawrenson
Geoffrey B. Arden
Publication date: 01-09-2006
Publisher: Springer-Verlag
Published in: Documenta Ophthalmologica / Issue 2/2006
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-006-9023-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Light and alcohol evoked electro-oculograms in cystic fibrosis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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