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Published in: Digestive Diseases and Sciences 9/2014

01-09-2014 | Original Article

Efficacy and Safety of Endoscopic Papillary Large Balloon Dilation for Large Bile Duct Stones in Elderly Patients

Authors: Ryosuke Tonozuka, Takao Itoi, Atsushi Sofuni, Fumihide Itokawa, Toshio Kurihara, Takayoshi Tsuchiya, Kentaro Ishii, Shujiro Tsuji, Nobuhito Ikeuchi, Junko Umeda, Reina Tanaka, Mitsuyoshi Honjyo, Shuntaro Mukai, Mitsuru Fujita, Fuminori Moriyasu

Published in: Digestive Diseases and Sciences | Issue 9/2014

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Abstract

Background

Minimally invasive interventions for choledocholithiasis are preferable in elderly patients because they tend to have multiple underlying disorders or a decreased activity of daily living. Endoscopic sphincterotomy and endoscopic papillary balloon dilation have been recognized as first-line treatments for choledocholithiasis excluding difficult cases such as large stones or multiple stones. Recently, the safety and efficacy of endoscopic papillary large balloon dilation (EPLBD) for difficult choledocholithiasis cases have been reported, although scarcely in elderly patients.

Aims

To investigate whether EPLBD can be safety and effectively performed in patients aged 75 years or older.

Methods

The medical records of 165 patients who underwent EPLBD from November 2006 to August 2013 were analyzed retrospectively. The patients were divided into 2 groups: Group A (≥75 years); Group B (<75 years).

Results

Some underlying diseases were significantly more common in Group A than in Group B (P < 0.05). However, there was no significant difference in the success rates in the first session (96.2 vs 95.0 %, P = 0.970) and in the final success rates (100 % in both groups) between Group A and Group B. The adverse event rates (2.9 vs 5.0 %, P = 0.783) and recurrence rates of choledocholithiasis (6.7 vs 10.0 %, P = 0.444) were not significantly different. Regarding patients with an altered anatomy, the EPLBD outcome was not significantly different.

Conclusion

EPLBD can be safely performed for elderly patients similarly to younger patients.
Literature
1.
go back to reference Hacker KA, Schultz CC, Helling TS. Choledochotomy for calculous disease in the elderly. Am J Surg. 1990;160:610–612.PubMedCrossRef Hacker KA, Schultz CC, Helling TS. Choledochotomy for calculous disease in the elderly. Am J Surg. 1990;160:610–612.PubMedCrossRef
2.
go back to reference Itoi T, Tsuyuguchi T, Takada T, et al. TG 13 indications and techniques for biliary drainage in acute cholangitis (with videos). J Hepatobiliary Pancreat Sci. 2013;20:71–80.PubMedCrossRef Itoi T, Tsuyuguchi T, Takada T, et al. TG 13 indications and techniques for biliary drainage in acute cholangitis (with videos). J Hepatobiliary Pancreat Sci. 2013;20:71–80.PubMedCrossRef
3.
go back to reference Sugiyama M, Atomi Y. Endoscopic sphincterotomy for bile duct stones in patients 90 years of age and older. Gastrointest Endosc. 2000;52:187–191.PubMedCrossRef Sugiyama M, Atomi Y. Endoscopic sphincterotomy for bile duct stones in patients 90 years of age and older. Gastrointest Endosc. 2000;52:187–191.PubMedCrossRef
4.
go back to reference Tsujino T, Yoshida H, Isayama H, et al. Endoscopic papillary balloon dilation for bile duct stone removal in patients 60 years old or younger. J Gastroenterol. 2010;45:1072–1079.PubMedCrossRef Tsujino T, Yoshida H, Isayama H, et al. Endoscopic papillary balloon dilation for bile duct stone removal in patients 60 years old or younger. J Gastroenterol. 2010;45:1072–1079.PubMedCrossRef
5.
go back to reference Mohammad Alizadeh AH, Afzali ES, Shahnazi A, et al. Utility and safety of ERCP in the elderly: a comparative study in Iran. Diagn Ther Endosc. 2012;2012:439320. Mohammad Alizadeh AH, Afzali ES, Shahnazi A, et al. Utility and safety of ERCP in the elderly: a comparative study in Iran. Diagn Ther Endosc. 2012;2012:439320.
6.
go back to reference Cotton PB, Lehman G, Vennes J, et al. Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991;37:383–393.PubMedCrossRef Cotton PB, Lehman G, Vennes J, et al. Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991;37:383–393.PubMedCrossRef
7.
go back to reference Freeman ML, Nelson DB, Sherman S, et al. Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996;335:909–918.PubMedCrossRef Freeman ML, Nelson DB, Sherman S, et al. Complications of endoscopic biliary sphincterotomy. N Engl J Med. 1996;335:909–918.PubMedCrossRef
8.
go back to reference Staritz M, Ewe K. Meyer zum Büschenfelde KH. Endoscopic papillary dilation (EPD) for the treatment of common bile duct stones and papillary stenosis. Endoscopy. 1983;15:197–198.PubMedCrossRef Staritz M, Ewe K. Meyer zum Büschenfelde KH. Endoscopic papillary dilation (EPD) for the treatment of common bile duct stones and papillary stenosis. Endoscopy. 1983;15:197–198.PubMedCrossRef
9.
go back to reference Yasuda I, Fujita N, Maguchi H, et al. Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones. Gastrointest Endosc. 2010;72:1154–1162.CrossRef Yasuda I, Fujita N, Maguchi H, et al. Long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation for bile duct stones. Gastrointest Endosc. 2010;72:1154–1162.CrossRef
10.
go back to reference Liao WC, Lee CT, Chang CY, et al. Randomized trial of 1-minute versus 5-minute endoscopic balloon dilation for extraction of bile duct stones. Gastrointest Endosc. 2010;72:1185–1191.CrossRef Liao WC, Lee CT, Chang CY, et al. Randomized trial of 1-minute versus 5-minute endoscopic balloon dilation for extraction of bile duct stones. Gastrointest Endosc. 2010;72:1185–1191.CrossRef
11.
go back to reference Binmoeller KF, Brucke M, Trou F, et al. Treatment of difficult bile duct stones using mechanical, electrohydraulic and extra corporeal shock wave lithotripsy. Endoscopy. 1993;25:201–206.PubMedCrossRef Binmoeller KF, Brucke M, Trou F, et al. Treatment of difficult bile duct stones using mechanical, electrohydraulic and extra corporeal shock wave lithotripsy. Endoscopy. 1993;25:201–206.PubMedCrossRef
12.
go back to reference Ersoz G, Tekesin O, Ozutemiz AO, et al. Biliary sphincterotomy plus dilation with a large balloon for bile duct stones that are difficult to extract. Gastrointest Endosc. 2003;57:156–159.PubMedCrossRef Ersoz G, Tekesin O, Ozutemiz AO, et al. Biliary sphincterotomy plus dilation with a large balloon for bile duct stones that are difficult to extract. Gastrointest Endosc. 2003;57:156–159.PubMedCrossRef
13.
go back to reference Maydeo A, Bhandari S. Balloon sphincteroplasty for removing difficult bile duct stones. Endoscopy. 2007;39:958–961.PubMedCrossRef Maydeo A, Bhandari S. Balloon sphincteroplasty for removing difficult bile duct stones. Endoscopy. 2007;39:958–961.PubMedCrossRef
14.
go back to reference Minami A, Hirose S, Nomoto T, et al. Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy. World J Gastroenterol. 2007;13:2179–2182.PubMedCrossRef Minami A, Hirose S, Nomoto T, et al. Small sphincterotomy combined with papillary dilation with large balloon permits retrieval of large stones without mechanical lithotripsy. World J Gastroenterol. 2007;13:2179–2182.PubMedCrossRef
15.
go back to reference Heo JH, Kang DH, Jung HJ, et al. Endoscopic sphincterotomy plus large-balloon dilation versus endoscopic sphincterotomy for removal of bile-duct stones. Gastrointest Endosc. 2007;66:720–726.PubMedCrossRef Heo JH, Kang DH, Jung HJ, et al. Endoscopic sphincterotomy plus large-balloon dilation versus endoscopic sphincterotomy for removal of bile-duct stones. Gastrointest Endosc. 2007;66:720–726.PubMedCrossRef
16.
go back to reference Attasaranya S, Cheon YK, Vittal H, et al. Large-diameter biliary orifice balloon dilation to aid in endoscopic bile duct stone removal: a multicenter series. Gastrointest Endosc. 2008;67:1046–1052.PubMedCrossRef Attasaranya S, Cheon YK, Vittal H, et al. Large-diameter biliary orifice balloon dilation to aid in endoscopic bile duct stone removal: a multicenter series. Gastrointest Endosc. 2008;67:1046–1052.PubMedCrossRef
17.
go back to reference Itoi T, Itokawa F, Sofuni A, et al. Endoscopic sphincterotomy combined with large balloon dilation can reduce the procedure time and fluoroscopy time for of large bile duct stones. Am J Gastroenterol. 2009;104:560–565.PubMedCrossRef Itoi T, Itokawa F, Sofuni A, et al. Endoscopic sphincterotomy combined with large balloon dilation can reduce the procedure time and fluoroscopy time for of large bile duct stones. Am J Gastroenterol. 2009;104:560–565.PubMedCrossRef
18.
go back to reference Draganov PV, Evans W, Fazel A, et al. Large size balloon dilation of the ampulla after biliary sphincterotomy can facilitate endoscopic extraction of difficult bile duct stones. J Clin Gastroenterol. 2009;43:782–786.PubMedCrossRef Draganov PV, Evans W, Fazel A, et al. Large size balloon dilation of the ampulla after biliary sphincterotomy can facilitate endoscopic extraction of difficult bile duct stones. J Clin Gastroenterol. 2009;43:782–786.PubMedCrossRef
19.
go back to reference Meine GC, Baron TH. Endoscopic papillary large-balloon dilation combined with endoscopic biliary sphincterotomy for the removal of bile duct stones (with video). Gastrointest Endosc. 2011;74:1119–1126.PubMedCrossRef Meine GC, Baron TH. Endoscopic papillary large-balloon dilation combined with endoscopic biliary sphincterotomy for the removal of bile duct stones (with video). Gastrointest Endosc. 2011;74:1119–1126.PubMedCrossRef
20.
go back to reference Teoh AY, Cheung FK, Hu B, et al. Randomized trial of endoscopic sphincterotomy with balloon dilation versus endoscopic sphincterotomy alone for removal of bile duct stones. Gastroenterology. 2013;144:341–345.PubMedCrossRef Teoh AY, Cheung FK, Hu B, et al. Randomized trial of endoscopic sphincterotomy with balloon dilation versus endoscopic sphincterotomy alone for removal of bile duct stones. Gastroenterology. 2013;144:341–345.PubMedCrossRef
21.
go back to reference Cotton PB, Eisen GM, Aabakken L, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71:446–454.PubMedCrossRef Cotton PB, Eisen GM, Aabakken L, et al. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71:446–454.PubMedCrossRef
22.
go back to reference Itoi T, Sofuni A, Itokawa F, et al. New large-diameter balloon-equipped sphincterotome for removal of large bile duct stones (with videos). Gastrointestinal Endosc. 2010;72:825–830.CrossRef Itoi T, Sofuni A, Itokawa F, et al. New large-diameter balloon-equipped sphincterotome for removal of large bile duct stones (with videos). Gastrointestinal Endosc. 2010;72:825–830.CrossRef
23.
go back to reference Itoi T, Ishii K, Itokawa F, et al. Large balloon dilation for removal of bile duct stones in patients who have undergone a Billroth II gastrectomy. Dig Endosc. 2010;22:S98–S102.PubMedCrossRef Itoi T, Ishii K, Itokawa F, et al. Large balloon dilation for removal of bile duct stones in patients who have undergone a Billroth II gastrectomy. Dig Endosc. 2010;22:S98–S102.PubMedCrossRef
24.
go back to reference Itoi T, Ishii K, Sofuni A, et al. Large balloon dilatation following endoscopic sphincterotomy using a balloon enteroscope for the bile duct stone extractions in patients with Roux-en-Y anastomosis. Dig Liver Dis. 2011;43:237–241.PubMedCrossRef Itoi T, Ishii K, Sofuni A, et al. Large balloon dilatation following endoscopic sphincterotomy using a balloon enteroscope for the bile duct stone extractions in patients with Roux-en-Y anastomosis. Dig Liver Dis. 2011;43:237–241.PubMedCrossRef
26.
go back to reference Park SJ, Kim JH, Hwang JC, et al. Factors predictive of adverse events following endoscopic papillary large balloon dilation: results from a multicenter series. Dig Dis Sci. 2013;58:1100–1109.PubMedCrossRef Park SJ, Kim JH, Hwang JC, et al. Factors predictive of adverse events following endoscopic papillary large balloon dilation: results from a multicenter series. Dig Dis Sci. 2013;58:1100–1109.PubMedCrossRef
27.
go back to reference Kim KO, Kim TN, Lee SH. Endoscopic papillary large balloon dilation for the treatment of recurrent bile duct stones in patients with prior sphincterotomy. J Gastroenterol. 2010;45:1283–1288.PubMedCrossRef Kim KO, Kim TN, Lee SH. Endoscopic papillary large balloon dilation for the treatment of recurrent bile duct stones in patients with prior sphincterotomy. J Gastroenterol. 2010;45:1283–1288.PubMedCrossRef
28.
go back to reference Laugier R, Bernard JP, Berthezene P, et al. Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion. 1991;50:202–211.PubMedCrossRef Laugier R, Bernard JP, Berthezene P, et al. Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly. Digestion. 1991;50:202–211.PubMedCrossRef
29.
go back to reference Bergman JJ, van Berkel AM, Bruno MJ, et al. A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy. Gastrointest Endosc. 2001;53:19–26.PubMedCrossRef Bergman JJ, van Berkel AM, Bruno MJ, et al. A randomized trial of endoscopic balloon dilation and endoscopic sphincterotomy for removal of bile duct stones in patients with a prior Billroth II gastrectomy. Gastrointest Endosc. 2001;53:19–26.PubMedCrossRef
30.
go back to reference Faylona JM, Qadir A, Chan AC, et al. Small-bowell perforations related to endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II gastrectomy. Endoscopy. 1999;31:546–549.PubMedCrossRef Faylona JM, Qadir A, Chan AC, et al. Small-bowell perforations related to endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II gastrectomy. Endoscopy. 1999;31:546–549.PubMedCrossRef
31.
go back to reference Shimatani M, Matsushita M, Takaoka M, et al. Effective “short” double-balloon enteroscope for diagnostic and therapeutic ERCP in patients with altered gastrointestinal anatomy: a large case series. Endoscopy. 2009;41:849–854.PubMedCrossRef Shimatani M, Matsushita M, Takaoka M, et al. Effective “short” double-balloon enteroscope for diagnostic and therapeutic ERCP in patients with altered gastrointestinal anatomy: a large case series. Endoscopy. 2009;41:849–854.PubMedCrossRef
32.
go back to reference Ciçek B, Parlak E, Dişibeyaz S, Koksal AS, Sahin B. Endoscopic retrograde cholangiopancreatography in patients with Billroth II gastroenterostomy. J Gastroenterol Hepatol. 2007;22:1210–1213.PubMedCrossRef Ciçek B, Parlak E, Dişibeyaz S, Koksal AS, Sahin B. Endoscopic retrograde cholangiopancreatography in patients with Billroth II gastroenterostomy. J Gastroenterol Hepatol. 2007;22:1210–1213.PubMedCrossRef
33.
go back to reference Kim KH, Rhu JH, Kim TN. Recurrence of bile duct stones after endoscopic papillary large balloon dilation combined with limited sphincterotomy: long-term follow-up study. Gut Liver. 2012;6:107–112.PubMedCentralPubMedCrossRef Kim KH, Rhu JH, Kim TN. Recurrence of bile duct stones after endoscopic papillary large balloon dilation combined with limited sphincterotomy: long-term follow-up study. Gut Liver. 2012;6:107–112.PubMedCentralPubMedCrossRef
34.
go back to reference Kim DI, Kim MH, Lee SK, et al. Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomy. Gastrointest Endosc. 2001;54:42–48.PubMedCrossRef Kim DI, Kim MH, Lee SK, et al. Risk factors for recurrence of primary bile duct stones after endoscopic biliary sphincterotomy. Gastrointest Endosc. 2001;54:42–48.PubMedCrossRef
35.
go back to reference Keizman D, Shalom MI, Konikoff FM. An angulated common bile duct predisposes to recurrent symptomatic bile duct stones after endoscopic stone extraction. Surg Endosc. 2006;20:1594–1599.PubMedCrossRef Keizman D, Shalom MI, Konikoff FM. An angulated common bile duct predisposes to recurrent symptomatic bile duct stones after endoscopic stone extraction. Surg Endosc. 2006;20:1594–1599.PubMedCrossRef
36.
go back to reference Jakobs R, Hartmann D, Kudis V, et al. Risk factor for symptomatic stone recurrence after transpapillary laser lithotripsy for difficult bile duct stones using a laser with a stone recognition system. Eur J Gastroenterol Hepatol. 2006;18:469–473.PubMedCrossRef Jakobs R, Hartmann D, Kudis V, et al. Risk factor for symptomatic stone recurrence after transpapillary laser lithotripsy for difficult bile duct stones using a laser with a stone recognition system. Eur J Gastroenterol Hepatol. 2006;18:469–473.PubMedCrossRef
37.
go back to reference Cheon YK, Lehman GA. Identification of risk factors for stone recurrence after endoscopic treatment of bile duct stones. Eur J Gastroenterol Hepatol. 2006;18:461–464.PubMedCrossRef Cheon YK, Lehman GA. Identification of risk factors for stone recurrence after endoscopic treatment of bile duct stones. Eur J Gastroenterol Hepatol. 2006;18:461–464.PubMedCrossRef
38.
go back to reference Itoi T, Sofuni A, Itokawa F, et al. Evaluation of residual bile duct stones by peroral cholangioscopy in comparison with balloon-cholangiography. Dig Endosc. 2010;22:S98–S102.PubMedCrossRef Itoi T, Sofuni A, Itokawa F, et al. Evaluation of residual bile duct stones by peroral cholangioscopy in comparison with balloon-cholangiography. Dig Endosc. 2010;22:S98–S102.PubMedCrossRef
Metadata
Title
Efficacy and Safety of Endoscopic Papillary Large Balloon Dilation for Large Bile Duct Stones in Elderly Patients
Authors
Ryosuke Tonozuka
Takao Itoi
Atsushi Sofuni
Fumihide Itokawa
Toshio Kurihara
Takayoshi Tsuchiya
Kentaro Ishii
Shujiro Tsuji
Nobuhito Ikeuchi
Junko Umeda
Reina Tanaka
Mitsuyoshi Honjyo
Shuntaro Mukai
Mitsuru Fujita
Fuminori Moriyasu
Publication date
01-09-2014
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 9/2014
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-014-3156-9

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