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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 8/2013

01-08-2013 | Review

A Systematic Review of SAPHO Syndrome and Inflammatory Bowel Disease Association

Authors: Juan E. Naves, Eduard Cabré, Míriam Mañosa, Dolors Grados, Alejandro Olivé, Eugeni Domènech

Published in: Digestive Diseases and Sciences | Issue 8/2013

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Abstract

Background

The association between inflammatory bowel disease (IBD) and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome (SAPHO syndrome) was first reported in 1992. To date, only case reports and short series have been published.

Aims

The purpose of this study was to report new cases and systematically review the literature on this association.

Materials and Methods

All patients with concomitant diagnosis of SAPHO syndrome and IBD were identified from the databases of the rheumatology and gastroenterology departments of our institution. In addition, we systematically searched for published full articles in Medlars Online International Literature via PubMed. Relevant information of each positive match was collected and all authors were contacted for additional clinical data.

Results

Three patients sharing both SAPHO syndrome and IBD were identified among the 62 patients with SAPHO syndrome (4.8 % of the SAPHO cohort) and the 1,309 patients with IBD (0.2 % of the IBD cohort) from our hospital database. After a systematic review, a total of 39 reported patients with concomitant diagnosis of SAPHO syndrome and IBD were identified. There was a female predominance and most had Crohn’s disease with colonic involvement.

Conclusions

The association of SAPHO syndrome and IBD seems to be rare among IBD patients but not so among SAPHO patients. SAPHO could be underdiagnosed because of the similarity of its clinical manifestations and some more common extraintestinal manifestations or drug-related side effects in IBD.
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Metadata
Title
A Systematic Review of SAPHO Syndrome and Inflammatory Bowel Disease Association
Authors
Juan E. Naves
Eduard Cabré
Míriam Mañosa
Dolors Grados
Alejandro Olivé
Eugeni Domènech
Publication date
01-08-2013
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 8/2013
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-013-2653-6

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