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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 7/2010

01-07-2010 | Review

Polymorphism of IL-8 in 251 Allele and Gastric Cancer Susceptibility: A Meta-Analysis

Authors: Jing Wang, Hai-Feng Pan, Yun-Tao Hu, Yu Zhu, Qian He

Published in: Digestive Diseases and Sciences | Issue 7/2010

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Abstract

Background

The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results.

Aim

To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility.

Methods

We performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate.

Results

The combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199–1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013–2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177–1.720; AA versus TT: OR = 1.586, 95% CI: 1.128–2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112–2.568) but not for noncardiac gastric cancer.

Conclusions

This meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.
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Metadata
Title
Polymorphism of IL-8 in 251 Allele and Gastric Cancer Susceptibility: A Meta-Analysis
Authors
Jing Wang
Hai-Feng Pan
Yun-Tao Hu
Yu Zhu
Qian He
Publication date
01-07-2010
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 7/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-009-0978-y

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