Top

Published in:

01-12-2008 | Original Paper

Ingesting 500 ml of Polyethylene Glycol Solution During Capsule Endoscopy Improves the Image Quality and Completion Rate to the Cecum

Authors: Hiroki Endo, Yasuyuki Kondo, Masahiko Inamori, Tomohiko R Ohya, Tatsuro Yanagawa, Masako Asayama, Kantaro Hisatomi, Takuma Teratani, Masato Yoneda, Atsushi Nakajima, Nobuyuki Matsuhashi

Published in: Digestive Diseases and Sciences | Issue 12/2008

Abstract

The benefits of bowel preparation prior to capsule endoscopy (CE) are controversial. The aim of this study was to examine whether ingesting a small amount of polyethylene glycol (PEG) during, not before, the CE procedure improves the image quality and the cecal completion rate. A prospective single-blind controlled study was conducted including 59 patients. The initial 32 patients (group A) received no preparation, and the subsequent 27 patients (group B) ingested 500 ml of PEG starting 30 min after swallowing the capsule. The capsule reached the cecum in 65.6% of the patients in group A and 88.9% of the patients in group B (P = 0.038). The use of PEG during CE examination significantly improved the image quality, and this effect was more pronounced in the distal ileum. Ingesting a small amount of PEG during CE examination significantly improves both the CE image quality and the cecal completion rate.

Iddan G, Meron G, Glukhovsky A, Swain P (2000) Wireless capsule endoscopy. Nature 405:417. doi:10.1038/35013140 PubMedCrossRef

Meron GD (2000) The development of the swallowable video capsule (M2A). Gastrointest Endosc 405:417

Appleyard M, Glukhovsky A, Swain P (2001) Wireless-capsule diagnostic endoscopy for recurrent small-bowel bleeding. N Engl J Med 344:232–3. doi:10.1056/NEJM200101183440316 PubMedCrossRef

Fireman Z, Mahajna E, Broide E, Shapiro M, Fish L, Sternberg A (2003) Diagnosing small bowel Crohn’s disease with wireless endoscopy. Gut 502:1122–1126

Eliakim R, Fischer D, Suissa A, Yassin K, Katz D, Guttman N, Migdal M (2003) Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease. Eur J Gastroenterol Hepatol 15:363–367. doi:10.1097/00042737-200304000-00005 PubMedCrossRef

Mylonaki M, Fritscher-Ravens A, Swain P (2003) Wireless capsule endoscopy: a comparison with push enteroscopy in patients with gastroscopy and colonoscopy negative in gastrointestinal bleeding. Gut 52:1222–1226. doi:10.1136/gut.52.8.1122 CrossRef

Hartmann D, Schilling D, Bolz G, Hahne M, Jakobs R, Siegel E, Weickert U, Adamek HE, Riemann JF (2003) Capsule endoscopy versus push enteroscopy in patients with occult gastrointestinal bleeding. Z Gastroenterol 41:377–382. doi:10.1055/s-2003-37313 PubMedCrossRef

Costamagna G, Shah SK, Riccioni ME, Foschia F, Mutignani M, Perri V, Vecchioli A, Brizi MG, Picciocchi A, Marano P (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:1385–1388. doi:10.1053/gast.2002.35988 CrossRef

Ell C, Remke S, May A, Helou L, Henrich R, Mayer G (2002) The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding. Endoscopy 34:685–689. doi:10.1055/s-2002-33446 PubMedCrossRef

10.

Pennazio M, Santucci R, Rondonotti E, Abbiati C, Beccari G, Rossini FP, De Franchis R (2004) Outcome of patients with obscure gastrointestinal bleeding after capsule endoscopy: report of 100 consecutive cases. Gastroenterology 126:643–653. doi:10.1053/j.gastro.2003.11.057 PubMedCrossRef

11.

Basit AW, Newton JM, Short MD, Waddington WA, Ell PJ, Lancey LF (2001) The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly water soluble drugs. Pharm Res 18(8):1146–1150. doi:10.1023/A:1010927026837 PubMedCrossRef

12.

Sgouros SN, Viazis N, Papaxoinis K, Vlachogiannakos J, Bergele C, Avgerinos A (2003) The necessity for bowel preparation before wireless capsule endoscopy: a prospective, randomized study [abstract]. Endoscopy 35(Suppl 2):A183

13.

Fireman Z, Kopelman Y, Fish L, Sternberg A, Scapa E, Mahajna E (2004) Effect of oral purgatives on gastric and small bowel transit time in capsule endoscopy. Isr Med Assoc J 6:521–523PubMed

14.

Dai N, Gubler C, Hengstler P, Meyenberger C, Bauerfeind P (2005) Improved capsule endoscopy after bowel preparation. Gastrointest Endosc 61:28–31. doi:10.1016/S0016-5107(04)02444-7 PubMedCrossRef

15.

Albert J, Gobel CM, Lesske J, Lotterer E, Nietsch H, Flieg WE (2004) Simethicone for small bowel preparation for capsule endoscopy: a systematic, single-blinded, controlled study. Gastrointest Endosc 59:487–491. doi:10.1016/S0016-5107(04)00003-3 PubMedCrossRef

16.

Ben-Soussan E, Savoye G, Antonietti M, Ramirez S, Ducrotte P, Lerebours E (2005) Is a 2-liter PEG preparation useful before capsule endoscopy? J Clin Gastroenterol 39:381–384. doi:10.1097/01.mcg.0000159271.43233.45 PubMedCrossRef

17.

Caddy GR, Moran L, Chong AK, Miller AM, Taylor AC, Desmond PV (2006) The effect of erythromycin on video capsule endoscopy intestinal-transit time. Gastrointestinal Endosc 63:262–266. doi:10.1016/j.gie.2005.07.043 CrossRef

18.

Costamagna G, Shah SK, Riccioni ME, Foschia F, Mutignani M, Perri V (2002) A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease. Gastroenterology 123:999–1005. doi:10.1053/gast.2002.35988 PubMedCrossRef

19.

Viazis N, Sqouros S, Papaxoinis K, Vlachoqiannakos J, Berqele C, Sklavos P, Panani A, Avgerinos A (2004) Bowel preparation increases the diagnostic yield of capsule endoscopy. Gastrointest Endosc 60:534–538. doi:10.1016/S0016-5107(04)01879-6 PubMedCrossRef

20.

Chun H, Kim Y, Choung R, Jeen Y, Lee H, Um S, Lee S, Choi J, Kim C, Ryu H, Hyun J (2003) Comparison of two bowel preparation for capsule endoscopy: NPO versus PEG [abstract]. Endoscopy 35(Suppl 2):A117

21.

Fireman Z, Paz R, Fish L, Kopelman Y, Mahajna E, Sternberg A, Scapa E (2003) Effect of different preparation on cleaning of the small bowel in capsule endoscopy studies [abstract]. Endoscopy 35(Suppl 2):A184

22.

Gubler CR, Hengstler PM, Bauerfeind P, Meyenberger C (2003) Capsule endoscopy (CE): impact of bowel preparation in 43 consecutive patients in 2 tertiary hospitals [abstract]. Endoscopy 35(Suppl 2):A182

23.

Niv Y, Niv G, Wiser K, Demarco DC (2005) Capsule endoscopy—comparison of two strategies of bowel preparation. Aliment Phamacol Ther 22:957–962. doi:10.1111/j.1365-2036.2005.02647.x CrossRef

24.

Pons V, Gonzalez B, Gonzalez C, Perez-Cuadrado E, Fernandez S, Fernandez-Urien I, Mata A, Espinos J, Perez Grueso MJ, Arguello L (2006) Evaluation of different bowel preparations for the study with capsule endoscopy: a prospective, randomized, controlled study [abstract]. The 5th international conference on capsule endoscopy, Paris, France, p 133

25.

Lapalus MG, Ben-Soussan E, Saurin JC, Jacob P, Coumaros D, Gaudric M, Heresbach D, Heyries L, Antonietti M, Gaudin JL, Favre O, Daudet J, D’Halluin PN, Ponchon T (2006) Capsule endoscopy and bowel preparation with oral sodium phosphate: a prospective randomized controlled trial [abstract]. The 5th international conference on capsule endoscopy, Paris, France, p 135

26.

Prasad M, Shetty A (2006) Effect of PEG preparation before capsule endoscopy on bowel transit time [abstract]. The 5th international conference on capsule endoscopy, Paris, France, p 137

27.

Shiotani A, Opekun AR, Graham DY (2007) Visualization of the small intestine using capsule endoscopy in healthy subjects. Dig Dis Sci 52:1019–1025. doi:10.1007/s10620-006-9558-6 PubMedCrossRef

28.

Niv Y, Niv G (2004) Capsule endoscopy: role of bowel preparation in successful visualization. Scand J Gastroenterol 39:1005–1009. doi:10.1080/00365520410003209 PubMedCrossRef

29.

Fireman Z, Paz D, Kopelman Y (2005) Capsule endoscopy: improving transit time and image view. World J Gastroenterol 11:5863–5866PubMed

30.

Ristvedt SL, McFarland EG, Weinstock LB, Thyssen EP (2003) Patient preferences for CT colonography, conventional colonoscopy and bowel preparation. Am J Gastroenterol 98:578–575. doi:10.1111/j.1572-0241.2003.07302.x PubMedCrossRef

31.

Knight LC, Parkman HP, Brown KL, Miller MA, Trate DM, Maurer AH, Fisher RS (1997) Delayed gastric emptying and decreased antral contractility in normal premenopausal women compared with men. Am J Gastroenterol 92:968–975PubMed

32.

Parkman HP, Harris AD, Miller MA, Fisher RS (1996) Influence of age, gender, and menstrual cycle on the normal electrogastrogram. Am J Gastroenterol 91:127–133PubMed

33.

Wedmann B, Schmidt G, Wegener M, Coenen C, Ricken D, Althoff J (1991) Effects of age and gender on fat-induced gallbladder contraction and gastric emptying of a caloric liquid meal: a sonographic study. Am J Gastroenterol 86:1765–1770PubMed

34.

Huston WR, Roehrkasse RL, Wald A (1989) Influence of gender and menopause on gastric emptying and motility. Gastroenterology 96:11–17

35.

Huston WR, Wald A (1987) Sex and menopausal status of subjects in gastric emptying studies. J Nucl Med 28:1926–1927PubMed

Title: Ingesting 500 ml of Polyethylene Glycol Solution During Capsule Endoscopy Improves the Image Quality and Completion Rate to the Cecum
Authors: Hiroki Endo
Yasuyuki Kondo
Masahiko Inamori
Tomohiko R Ohya
Tatsuro Yanagawa
Masako Asayama
Kantaro Hisatomi
Takuma Teratani
Masato Yoneda
Atsushi Nakajima
Nobuyuki Matsuhashi
Publication date: 01-12-2008
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 12/2008
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0292-0

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 12/2008

Patient Educational Media Preferences for Information About Irritable Bowel Syndrome (IBS)

Effects of a Long-Term High-Fat Diet and Switching from a High-Fat to Low-Fat, Standard Diet on Hepatic Fat Accumulation in Sprague-Dawley Rats

Infiltration of Mast Cells in Rat Colon Is a Consequence of Ischemia/Reperfusion

Mannan-Binding Lectin Levels Related to Spontaneous Abortion in Brazilian Patients with Celiac Disease

Serological Proteomics of Gastritis: Degradation of Apolipoprotein A-I and Alpha1-Antitrypsin Is a Common Response to Inflammation Irrespective of Helicobacter pylori Infection

Hemochromatosis Gene Status as a Risk Factor for Barrett’s Esophagus

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials