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01-10-2008 | Original Paper

Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia

Authors: Craig A. Friesen, Zhiyue Lin, Meenal Singh, Vivekanand Singh, Jennifer V. Schurman, Nanci Burchell, Jose T. Cocjin, Richard W. McCallum

Published in: Digestive Diseases and Sciences | Issue 10/2008

Abstract

The aims of the current study were to determine the activation states of antral eosinophils and mast cells and to evaluate the interactions of antral inflammatory cells with gastric emptying and electrogastrography (EGG) in 30 pediatric patients with functional dyspepsia. Eosinophil degranulation was moderate in 42% and extensive in 54% of patients. Mast cell degranulation was >50% in 81% of patients. Elevated mast cell density was associated with slower one hour gastric emptying and increased preprandial dysrhythmia. Mast cell density correlated with the preprandial percentage tachygastria. CD3+ cell density correlated with the preprandial percentage tachygastria also, but only in patients with increased eosinophil density. In conclusion, antral eosinophils and mast cells are significantly activated in pediatric functional dyspepsia. Mast cell density is associated with delayed gastric emptying and preprandial dysrhythmia, suggesting that there may be an interaction between antral inflammation and gastric electromechanical dysfunction in the pathophysiology of pediatric functional dyspepsia.

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Title: Antral Inflammatory Cells, Gastric Emptying, and Electrogastrography in Pediatric Functional Dyspepsia
Authors: Craig A. Friesen
Zhiyue Lin
Meenal Singh
Vivekanand Singh
Jennifer V. Schurman
Nanci Burchell
Jose T. Cocjin
Richard W. McCallum
Publication date: 01-10-2008
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 10/2008
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0207-0

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