Published in:
01-07-2008 | Original Paper
Liver Transplantation in the Setting of Hepatocellular Carcinoma and Portal Vein Thrombosis: A Challenging Dilemma?
Authors:
Georgios C. Sotiropoulos, Arnold Radtke, Klaus J. Schmitz, Ernesto P. Molmenti, Tobias Schroeder, Fuat H. Saner, Hideo A. Baba, Ioannis Fouzas, Christoph E. Broelsch, Massimo Malagó, Hauke Lang
Published in:
Digestive Diseases and Sciences
|
Issue 7/2008
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Abstract
Background Portal vein thrombosis (PVT) represents a potentially unfavorable prognostic factor in liver transplantation (LT) for hepatocellular carcinoma (HCC). However, it is frequently difficult to establish preoperatively whether the thrombus is associated with tumor invasion or with stagnant flow. The purpose of this study was to further address this controversial issue. Patients and methods We evaluated 12 consecutive patients who underwent liver transplantation for HCC in the setting of PVT. Results The origin of PVT in HCC patients could be accurately evaluated in 58% of the patients. Forty-two percent of patients had no evident portal vein invasion and only 17% of cases had tumor thrombi. One-third of patients experienced tumor recurrence within the first posttransplant year, and one-third of patients became long-term survivors (median survival of 36 months) with no evidence of tumor recurrence. One-year survival was 92%. Nine patients are currently alive after a median follow-up period of 25 months. Conclusions PVT in the setting of HCC is characterized by poor patient outcome. However, a respectable number of instances are not accurately evaluated preoperatively, making the decision to exclude these patients from LT sometimes a challenging dilemma.