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01-02-2007 | Original Paper

Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol

Authors: Alessandra Gambero, Marta Maróstica, Tagliane Liza Becker, José Pedrazzoli Jr.

Published in: Digestive Diseases and Sciences | Issue 2/2007

Abstract

In this study, we evaluated the effect of two different dosages of therapeutically prescribed nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, diclofenac, nimesulide, meloxicam, and celecoxib (ED80 for COX-1 and COX-2) on normal gastric mucosa and mucosa, previously exposed to 20% ethanol. At COX-2-inhibiting dosages, the NSAIDs tested were nonulcerogenic, and the same response profile was observed in “adapted” stomachs. Interestingly, low doses of nimesulide and celecoxib increase the levels of Prostaglandin E₂ and COX-2, and protect against subsequent 100% ethanol exposition, suggesting that these drugs may act as “mild irritants” to gastric mucosa. The ulcerogenic response to NSAIDs was prevented by the previous 20% ethanol exposition, probably the result of nitric oxide synthesis, because PGE₂ levels in gastric mucosa were reduced by these agents and a concomitant nitric oxide blockade reversed this protection.

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Title: Effect of Different Cyclooxygenase Inhibitors on Gastric Adaptive Cytoprotection Induced by 20% Ethanol
Authors: Alessandra Gambero
Marta Maróstica
Tagliane Liza Becker
José Pedrazzoli Jr.
Publication date: 01-02-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Digestive Diseases and Sciences / Issue 2/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9487-4

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