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The International Journal of Cardiovascular Imaging

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01-01-2022 | Angiography | Original Paper

The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon

Authors: Gonul Aciksari, Gokhan Cetinkal, Mehmet Kocak, Adem Atici, Fatma Betul Celik, Mustafa Caliskan

Published in: The International Journal of Cardiovascular Imaging | Issue 1/2022

Abstract

In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p < 0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.59–2.32; p = 0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group (r = 0.311, p < 0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI 0.65–0.81; p < 0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.

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Title: The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon
Authors: Gonul Aciksari
Gokhan Cetinkal
Mehmet Kocak
Adem Atici
Fatma Betul Celik
Mustafa Caliskan
Publication date: 01-01-2022
Publisher: Springer Netherlands
Keywords: Angiography
Myocardial Infarction
Published in: The International Journal of Cardiovascular Imaging / Issue 1/2022
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-021-02387-w

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The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon

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