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The International Journal of Cardiovascular Imaging

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01-03-2014 | Original paper

Randomized comparison of biolimus-eluting stents with biodegradable polymer versus everolimus-eluting stents with permanent polymer coatings assessed by optical coherence tomography

Authors: Tomohisa Tada, Adnan Kastrati, Robert A. Byrne, Tibor Schuster, Rezarta Cuni, Lamin A. King, Salvatore Cassese, Michael Joner, Jürgen Pache, Steffen Massberg, Albert Schömig, Julinda Mehilli

Published in: The International Journal of Cardiovascular Imaging | Issue 3/2014

Abstract

We sought to compare the healing patterns of biolimus-eluting stents with biodegradable polymer (BP-BES, Nobori) versus everolimus-eluting stents with permanent polymer (PP-EES, Xience) using intravascular optical coherence tomography (OCT). A total of 34 patients undergoing treatment of de novo coronary lesions were randomly assigned to receive BP-BES (n = 15) or PP-EES (n = 19). Stent tissue coverage and apposition as well as the incidence of peri-strut low intensity area (PLIA) were assessed by OCT at 6–8 months. Generalized linear mixed models were used to account for clustered data. OCT imaging was available for 17 lesions with 2,805 struts in the BP-BES group and 22 lesions with 3,890 struts in the PP-EES group. BP-BES as compared to PP-EES showed similar rates of uncovered struts (479 vs. 588, odds ratio (OR) 1.54 (95 % CI 0.63–3.79), P = 0.34) and malapposed struts (46 vs. 32 struts, OR 1.64 [95 % CI 0.21–12.5], P = 0.64). Three lesions with BP-BES (17.6 %) versus 5 lesions with PP-EES (22.7 %) had >30 % uncovered struts (P = 0.78). The proportion of patients with PLIA was similar in both groups (BP-BES 41.2 % vs. PP-EES 36.4 %, OR 1.11 [95 % CI 0.43–2.87], P = 0.83). New generation BP-BES as compared to PP-EES showed similar stent coverage and apposition as assessed by OCT at 6–8 months. In addition, PLIA—possible markers of delayed arterial healing—were observed with similar frequency in both groups.

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Title: Randomized comparison of biolimus-eluting stents with biodegradable polymer versus everolimus-eluting stents with permanent polymer coatings assessed by optical coherence tomography
Authors: Tomohisa Tada
Adnan Kastrati
Robert A. Byrne
Tibor Schuster
Rezarta Cuni
Lamin A. King
Salvatore Cassese
Michael Joner
Jürgen Pache
Steffen Massberg
Albert Schömig
Julinda Mehilli
Publication date: 01-03-2014
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 3/2014
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-014-0376-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Randomized comparison of biolimus-eluting stents with biodegradable polymer versus everolimus-eluting stents with permanent polymer coatings assessed by optical coherence tomography

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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