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The International Journal of Cardiovascular Imaging

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01-06-2013 | Original Paper

Improvement of left ventricular longitudinal systolic function after transcatheter aortic valve implantation: a speckle-tracking prospective study

Authors: Flavio D’Ascenzi, Matteo Cameli, Alessandro Iadanza, Matteo Lisi, Valerio Zacà, Rosanna Reccia, Valeria Curci, Andrea Torrisi, Giuseppe Sinicropi, Carlo Pierli, Sergio Mondillo

Published in: The International Journal of Cardiovascular Imaging | Issue 5/2013

Abstract

Transcatheter aortic valve implantation (TAVI) is able to determine a significant improvement of left ventricular ejection fraction (LVEF). The variations of LV global longitudinal strain (GLS) have not been yet investigated in TAVI patients with reduced LVEF. The aim of this study was to determine the effects of TAVI on LV function by 2D speckle-tracking echocardiography (STE) in patients with reduced LVEF. Eighteen consecutive patients undergoing TAVI in our centre were prospectively enrolled. Echocardiography was performed pre-procedurally the day of TAVI and at 40-day and 3-month follow-up (FU). The mean age of TAVI patients was 79.75 ± 7.68 years. The mean EuroSCORE was 26.59 ± 14.62 %. A significant decrease of mean trans-aortic gradient was observed 40 days after TAVI (51.69 ± 18.82 vs. 9.62 ± 3.28 mmHg, p < 0.0001). LV mass index significantly decreased at 40-day FU (165.72 ± 37.75 vs. 145.52 ± 31.32 g/m², p < 0.001) with a further reduction at 3-month FU (136.91 ± 26.91 g/m², p < 0.05 in comparison with 40-day FU). The mean pre-procedural LVEF was 45.87 ± 7.95 %. LVEF significantly increased at 40-day FU (55.20 ± 5.91 %, p < 0.05) and remained stable at 3-month FU (55.58 ± 6.14 %). Interestingly, an early improvement of LV GLS was observed at 40-day FU (−11.09 ± 3.40 vs. −14.40 ± 3.68 %, p < 0.001) with a slight further increase at 3-month FU (−14.71 ± 3.56 %). Our results indicate that significant improvements of LVEF and LV GLS can be observed in patients undergoing TAVI with impaired LVEF. Two-dimensional STE was able to detect the reverse remodeling of LV function, adding further insights into the assessment of LV mid-term recovery after TAVI.

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Title: Improvement of left ventricular longitudinal systolic function after transcatheter aortic valve implantation: a speckle-tracking prospective study
Authors: Flavio D’Ascenzi
Matteo Cameli
Alessandro Iadanza
Matteo Lisi
Valerio Zacà
Rosanna Reccia
Valeria Curci
Andrea Torrisi
Giuseppe Sinicropi
Carlo Pierli
Sergio Mondillo
Publication date: 01-06-2013
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 5/2013
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-012-0175-5

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Improvement of left ventricular longitudinal systolic function after transcatheter aortic valve implantation: a speckle-tracking prospective study

Abstract

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Abstract

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