Top

Published in:

01-11-2017 | Original paper

Prevalence of oral HPV infection among healthy individuals and head and neck cancer cases in the French West Indies

Authors: Aviane Auguste, Stanie Gaëte, Cécile Herrmann-Storck, Leah Michineau, Clarisse Joachim, Jacqueline Deloumeaux, Suzy Duflo, Danièle Luce

Published in: Cancer Causes & Control | Issue 11/2017

Abstract

Purpose

Human papillomavirus (HPV) is known to play a role in the development of head and neck squamous cell carcinomas (HNSCC) and to date, no study has reported on the association between oral HPV infection and HNSCC in the Caribbean. The objective was to determine the prevalence of oral HPV infection in the French West Indies (FWI), overall and by HPV genotype, among HNSCC cases and healthy population controls.

Method

We used data from a population-based case–control study conducted in the FWI. The prevalence of oral HPV was estimated separately among 100 HNSCC cases (mean age 59 years) and 308 population controls (mean age 57 years). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a logistic regression adjusting for age, sex, tobacco, and alcohol consumption, to assess the association between oral HPV infection and HNSCC.

Results

Prevalence of oral HPV infections was 26% in controls (30% in men and 14% in women) and 36% in HNSCC cases (36% in men, 33% in women). HPV52 was the most commonly detected genotype, in cases and in controls. The prevalence of HPV16, HPV33, and HPV51 was significantly higher in cases than in controls (p = 0.0340, p = 0.0472, and 0.0144, respectively). Oral infection with high-risk HPV was associated with an increase in risk of HNSCC (OR 1.99, 95% CI 0.95–4.15). HPV16 was only associated with oropharyngeal cancer (OR 16.01, 95% CI 1.67–153.64).

Conclusion

This study revealed a high prevalence of oral HPV infection in this middle-aged Afro-Caribbean population, and a specific distribution of HPV genotypes. These findings may provide insight into HNSCC etiology specific to the FWI.

Ferlay J, Soerjomataram I, Ervik M et al (2013) GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11. In: International agency for research on cancer. http://globocan.iarc.fr. Accessed 30 May 2017

Jean-Baptiste Richard (2015) Premiers résultats du Baromètre santé DOM 2014—Résultats détaillés selon le DOM, l’âge et le sexe—2015

Gillison ML, Alemany L, Snijders PJF et al (2012) Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis. Vaccine 30:F34–F54. doi: 10.1016/j.vaccine.2012.05.070 CrossRefPubMed

Fakhry C, Westra WH, Li S et al (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100:261–269. doi: 10.1093/jnci/djn011 CrossRefPubMed

Ang KK, Harris J, Wheeler R et al (2010) Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363:24–35. doi: 10.1056/NEJMoa0912217 CrossRefPubMedPubMedCentral

Ragin CCR, Taioli E (2007) Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 121:1813–1820. doi: 10.1002/ijc.22851 CrossRefPubMed

Ndiaye C, Mena M, Alemany L et al (2014) HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol 15:1319–1331. doi: 10.1016/S1470-2045(14)70471-1 CrossRefPubMed

Kreimer AR, Clifford GM, Boyle P, Franceschi S (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomark Prev 14:467–475. doi: 10.1158/1055-9965.EPI-04-0551 CrossRef

Kreimer AR, Bhatia RK, Messeguer AL et al (2010) Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis 37:386–391. doi: 10.1097/OLQ.0b013e3181c94a3b PubMed

10.

Luce D, Stücker I, ICARE Study Group (2011) Investigation of occupational and environmental causes of respiratory cancers (ICARE): a multicenter, population-based case-control study in France. BMC Public Health 11:928. doi: 10.1186/1471-2458-11-928 CrossRefPubMedPubMedCentral

11.

Iwasiow RM, Desbois A, Birnboim HC (2011) Long-term stability of DNA from saliva samples stored in the Oragene self-collection kit. DNA Genotek, Ottawa

12.

Kleter B, van Doorn LJ, Schrauwen L et al (1999) Development and clinical evaluation of a highly sensitive PCR-reverse hybridization line probe assay for detection and identification of anogenital human papillomavirus. J Clin Microbiol 37:2508–2517PubMedPubMedCentral

13.

Ragin C, Liu JC, Jones G et al (2016) Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients. Carcinogenesis. doi: 10.1093/carcin/bgw203 PubMed

14.

D’Souza G, Kreimer AR, Viscidi R et al (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956. doi: 10.1056/NEJMoa065497 CrossRefPubMed

15.

Pintos J, Black MJ, Sadeghi N et al (2008) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol 44:242–250. doi: 10.1016/j.oraloncology.2007.02.005 CrossRefPubMed

16.

Anaya-Saavedra G, Ramírez-Amador V, Irigoyen-Camacho ME et al (2008) High association of human papillomavirus infection with oral cancer: a case-control study. Arch Med Res 39:189–197. doi: 10.1016/j.arcmed.2007.08.003 CrossRefPubMed

17.

Tachezy R, Klozar J, Rubenstein L et al (2009) Demographic and risk factors in patients with head and neck tumors. J Med Virol 81:878–887. doi: 10.1002/jmv.21470 CrossRefPubMed

18.

Laprise C, Madathil SA, Schlecht NF et al (2017) Human papillomavirus genotypes and risk of head and neck cancers: results from the HeNCe Life case-control study. Oral Oncol 69:56–61. doi: 10.1016/j.oraloncology.2017.03.013 CrossRefPubMed

19.

Gillison ML, Broutian T, Pickard RKL et al (2012) Prevalence of oral HPV infection in the United States, 2009–2010. JAMA 307:693–703. doi: 10.1001/jama.2012.101 CrossRefPubMed

20.

Kreimer AR, Villa A, Nyitray AG et al (2011) The epidemiology of oral HPV infection among a multinational sample of healthy men. Cancer Epidemiol Biomark Prev 20:172–182. doi: 10.1158/1055-9965.EPI-10-0682 CrossRef

21.

Ragin CCR, Wheeler VW, Wilson JB et al (2007) Distinct distribution of HPV types among cancer-free Afro-Caribbean women from Tobago. Biomarkers 12:510–522. doi: 10.1080/13547500701340384 CrossRefPubMed

22.

Cordel N, Ragin C, Trival M et al (2015) High-risk human papillomavirus cervical infections among healthy women in Guadeloupe. Int J Infect Dis 41:13–16. doi: 10.1016/j.ijid.2015.10.012 CrossRefPubMedPubMedCentral

23.

Schwartz SM, Daling JR, Doody DR et al (1998) Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 90:1626–1636CrossRefPubMed

24.

D’Souza G, Kreimer AR, Viscidi R et al (2007) Case–control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956CrossRefPubMed

25.

Smith EM, Ritchie JM, Summersgill KF et al (2004) Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 108:766–772. doi: 10.1002/ijc.11633 CrossRefPubMed

26.

Zhao M, Rosenbaum E, Carvalho AL et al (2005) Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int J Cancer 117:605–610. doi: 10.1002/ijc.21216 CrossRefPubMed

27.

Wasserman JK, Rourke R, Purgina B et al (2017) HPV DNA in saliva from patients with SCC of the head and neck is specific for p16-positive oropharyngeal tumours. J Otolaryngol Head Neck Surg 46:3. doi: 10.1186/s40463-016-0179-6 CrossRefPubMedPubMedCentral

28.

Peterson CE, Khosla S, Chen LF et al (2016) Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012). J Cancer Res Clin Oncol 142:1715–1726. doi: 10.1007/s00432-016-2182-8 CrossRefPubMed

Title: Prevalence of oral HPV infection among healthy individuals and head and neck cancer cases in the French West Indies
Authors: Aviane Auguste
Stanie Gaëte
Cécile Herrmann-Storck
Leah Michineau
Clarisse Joachim
Jacqueline Deloumeaux
Suzy Duflo
Danièle Luce
Publication date: 01-11-2017
Publisher: Springer International Publishing
Published in: Cancer Causes & Control / Issue 11/2017
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-017-0966-z

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 11/2017

Gatekeepers’ perceptions of the quality and availability of services for breast and cervical cancer patients in the English-speaking Windward Islands: an exploratory investigation

Outcomes of treatment in men with prostate cancer at the cancer centre Bahamas

Gynecologic cancer mortality in Trinidad and Tobago and comparisons of mortality-to-incidence rate ratios across global regions

Kaiso is highly expressed in TNBC tissues of women of African ancestry compared to Caucasian women

Reliance on medicinal plant therapy among cancer patients in Jamaica

Prostate cancer clinical presentation, incidence, mortality and survival in Guadeloupe over the period 2008–2013 from a population-based cancer registry

Keynote webinar | Spotlight on antibody–drug conjugates in cancer