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Cancer Causes & Control

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01-10-2013 | Original paper

Circulating C-peptide level is a predictive factor for colorectal neoplasia: evidence from the meta-analysis of prospective studies

Authors: Li Chen, Lixia Li, Yunpeng Wang, Peng Li, Liang Luo, Bo Yang, Hao Wang, Meizhu Chen

Published in: Cancer Causes & Control | Issue 10/2013

Abstract

Purpose

C-peptide, a hormone secreted by the pancreas, is a marker for insulin production and hyperinsulinemia. Epidemiological studies have suggested an association between circulating C-peptide level and colorectal neoplasia risk; however, the results were not always consistent. Herein, we conducted a systematic review and meta-analysis study to evaluate the association between circulating C-peptide level and the colorectal neoplasia risk.

Methods

The PubMed database was searched for the eligibility studies updated to May 2013, which prospectively evaluated the association between circulating C-peptide level and colorectal neoplasia risk. The summary estimates and 95 % confidential intervals (95 % CIs) for those with the highest quantile C-peptide level in contrast to the lowest quantile were estimated with the random-effects model. Heterogeneity between the studies was assessed with the Q test and the I ² statistic. Potential publication bias was evaluated with the Egger’s test.

Results

We identified 9 nested case–control studies that have recruited a total of 3,109 cases and 4,285 controls met the criteria. From the meta-analysis, we found that subjects with high circulating C-peptide were associated with a 37 % increased colorectal neoplasia risk [pooled odds ratios (OR) 1.37, 95 % CI 1.09–1.72] under the random-effects model. In the stratification studies, we found the association was more prominent in the men (pooled OR 2.34, 95 % CI 1.36–4.04) compared to women (pooled OR 1.41, 95 % CI 0.89–2.25). Significant association between circulating C-peptide level and colon cancer risk was found (pooled OR 1.72, 95 % CI 1.26–2.36), but not for rectal cancer (pooled OR 1.14, 95 % CI 0.75–1.73). No significant publication bias was found for any meta-analysis study.

Conclusion

In conclusion, the results of the meta-analysis studies suggested that higher circulating C-peptide could be a predictive factor for higher colorectal neoplasia susceptibility.

Jemal A, Bray F, Center MM, Ferlay J, Ward E et al (2011) Global cancer statistics. CA Cancer J Clin 61:69–90PubMedCrossRef

Center MM, Jemal A, Smith RA, Ward E (2009) Worldwide variations in colorectal cancer. CA Cancer J Clin 59:366–378PubMedCrossRef

Center MM, Jemal A, Ward E (2009) International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev 18:1688–1694PubMedCrossRef

Li M, Zhou Y, Chen P, Yang H, Yuan X et al (2011) Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature. PLoS ONE 6:e18251PubMedCrossRef

Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB et al (2008) Smoking and colorectal cancer: a meta-analysis. JAMA 300:2765–2778PubMedCrossRef

Fedirko V, Tramacere I, Bagnardi V, Rota M, Scotti L et al (2011) Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. Ann Oncol 22:1958–1972PubMedCrossRef

Samad AK, Taylor RS, Marshall T, Chapman MA (2005) A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Dis 7:204–213PubMedCrossRef

Chan DS, Lau R, Aune D, Vieira R, Greenwood DC et al (2011) Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS ONE 6:e20456PubMedCrossRef

Huncharek M, Muscat J, Kupelnick B (2009) Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies. Nutr Cancer 61:47–69PubMedCrossRef

10.

Campbell PT, Jacobs ET, Ulrich CM, Figueiredo JC, Poynter JN et al (2010) Case-control study of overweight, obesity, and colorectal cancer risk, overall and by tumor microsatellite instability status. J Natl Cancer Inst 102:391–400PubMedCrossRef

11.

Giovannucci E (2001) Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 131:3109S–3120SPubMed

12.

Shikata K, Ninomiya T, Kiyohara Y (2013) Diabetes mellitus and cancer risk: review of the epidemiological evidence. Cancer Sci 104:9–14PubMedCrossRef

13.

Sandhu MS, Dunger DB, Giovannucci EL (2002) Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst 94:972–980PubMedCrossRef

14.

Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C et al (2000) Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst 92:1592–1600PubMedCrossRef

15.

Ma J, Giovannucci E, Pollak M, Leavitt A, Tao Y et al (2004) A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst 96:546–553PubMedCrossRef

16.

Wei EK, Ma J, Pollak MN, Rifai N, Fuchs CS et al (2005) A prospective study of C-peptide, insulin-like growth factor-I, insulin-like growth factor binding protein-1, and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 14:850–855PubMedCrossRef

17.

Wei EK, Ma J, Pollak MN, Rifai N, Fuchs CS et al (2006) C-peptide, insulin-like growth factor binding protein-1, glycosylated hemoglobin, and the risk of distal colorectal adenoma in women. Cancer Epidemiol Biomarkers Prev 15:750–755PubMedCrossRef

18.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188PubMedCrossRef

19.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634PubMedCrossRef

20.

Stattin P, Lukanova A, Biessy C, Soderberg S, Palmqvist R et al (2004) Obesity and colon cancer: does leptin provide a link? Int J Cancer 109:149–152PubMedCrossRef

21.

Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S et al (2007) Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. Int J Cancer 120:2007–2012PubMedCrossRef

22.

Jenab M, Riboli E, Cleveland RJ, Norat T, Rinaldi S et al (2007) Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 121:368–376PubMedCrossRef

23.

Stocks T, Lukanova A, Johansson M, Rinaldi S, Palmqvist R et al (2008) Components of the metabolic syndrome and colorectal cancer risk; a prospective study. Int J Obes (Lond) 32:304–314CrossRef

24.

Tsilidis KK, Brancati FL, Pollak MN, Rifai N, Clipp SL et al (2010) Metabolic syndrome components and colorectal adenoma in the CLUE II cohort. Cancer Causes Control 21:1–10PubMedCrossRef

25.

Lin JH, Zhang SM, Rexrode KM, Manson JE, Chan AT, et al (2012) Association between sex hormones and colorectal cancer risk in men and women. Clin Gastroenterol Hepatol

26.

Zhang X, Smith-Warner SA, Chan AT, Wu K, Spiegelman D et al (2011) Aspirin use, body mass index, physical activity, plasma C-peptide, and colon cancer risk in US health professionals. Am J Epidemiol 174:459–467PubMedCrossRef

27.

Giovannucci E (1995) Insulin and colon cancer. Cancer Causes Control 6:164–179PubMedCrossRef

28.

Bruce WR, Giacca A, Medline A (2000) Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 9:1271–1279PubMed

29.

Fung TT, Rimm EB, Spiegelman D, Rifai N, Tofler GH et al (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am J Clin Nutr 73:61–67PubMed

30.

Barone M, Lofano K, De Tullio N, Licinio R, Albano F et al (2012) Dietary, endocrine, and metabolic factors in the development of colorectal cancer. J Gastrointest Cancer 43:13–19PubMedCrossRef

31.

Vargas AJ, Thompson PA (2012) Diet and nutrient factors in colorectal cancer risk. Nutr Clin Pract 27:613–623PubMedCrossRef

32.

Fung TT, Hu FB, Schulze M, Pollak M, Wu T et al (2012) A dietary pattern that is associated with C-peptide and risk of colorectal cancer in women. Cancer Causes Control 23:959–965PubMedCrossRef

33.

Hills CE, Brunskill NJ (2008) Intracellular signalling by C-peptide. Exp Diabetes Res 2008:635158PubMedCrossRef

34.

Ning Y, Wang L, Giovannucci EL (2010) A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies. Obes Rev 11:19–30PubMedCrossRef

35.

Canderelli R, Leccesse LA, Miller NL, Unruh Davidson J (2007) Benefits of hormone replacement therapy in postmenopausal women. J Am Acad Nurse Pract 19:635–641PubMedCrossRef

Title: Circulating C-peptide level is a predictive factor for colorectal neoplasia: evidence from the meta-analysis of prospective studies
Authors: Li Chen
Lixia Li
Yunpeng Wang
Peng Li
Liang Luo
Bo Yang
Hao Wang
Meizhu Chen
Publication date: 01-10-2013
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 10/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0261-6

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Abstract

Purpose

Methods

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Conclusion

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