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01-10-2013 | Original paper

The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms

Authors: Cristina Fortes, Simona Mastroeni, Paolo Boffetta, Gianluca Antonelli, Maria Antonietta Pilla, Giordano Bottà, Patrizia Anzidei, Federica Venanzetti

Published in: Cancer Causes & Control | Issue 10/2013

Abstract

Purposes

The authors examined the association between coffee consumption and cutaneous melanoma and the implication of GSTM1 and GSTT1 polymorphisms.

Methods

A hospital-based case–control study was conducted in the inpatient wards of IDI-San Carlo Rome, Italy, including 304 incident cases of cutaneous melanoma and 305 controls. Information on socio-demographic characteristics, medical history, smoking, sun exposure, pigmentary characteristics and diet was collected for all subjects. Within the study, individual patterns at two polymorphic genes (GSTM1 and GSTT1) belonging to glutathione S-transferases family were investigated in 188 cases of cutaneous melanoma and 152 controls. Logistic regression was the method used to estimate odds ratio and 95 % confidence intervals.

Results

High frequency of coffee drinking (>once daily), compared with low-frequency consumption of coffee (≤7 times weekly) was associated with a protective effect for cutaneous melanoma (OR 0.46; 95 % CI 0.31–0.68) after adjusting for sex, age, education, hair colour, common nevi, skin phototype, and sunburn episodes in childhood. When stratified by GSTM1 and GSTT1 genotype, the protective effect of coffee was extremely high for subjects with both GSTM1 and GSTT1 null polymorphisms (OR 0.01; 95 % CI 0.0003–0.54).

Conclusions

Our results show a protective effect of coffee consumption for cutaneous melanoma, in particular for those with homozygous deletion for GSTM1 and GSTT1.

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De Vries E, Coebergh JW (2005) Melanoma incidence has risen in Europe. BMJ 331(7518):698PubMedCrossRef

Gandini S, Sera F, Cattaruzza MS et al (2005) Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer 4:45–60CrossRef

Curtin JA, Fridlyand J, Kageshita T et al (2005) Distinct sets of genetic alterations in melanoma. N Engl J Med 353:2135–2147PubMedCrossRef

Fortes C, de Vries E (2008) Nonsolar occupational risk factors for cutaneous melanoma. Int J Dermatol 47:319–328PubMedCrossRef

International Agency for Research on Cancer (1991) IARC Mongraph on the evaluation of the carcinogenic risks to humans. In: Coffee, tea, mate, methylxanthines and methylglyoxal, vol 51. IARC, Lyon, France

Je Y, Giovannucci E (2012) Coffee consumption and risk of endometrial cancer: findings from a large up-to-date meta-analysis. Int J Cancer 7:1700–1710CrossRef

Galeone C, Turati F, La Vecchia C et al (2010) Coffee consumption and risk of colorectal cancer: a meta-analysis of case-control. Cancer Causes Control 2:1949–1959CrossRef

Turati F, Galeone C, Edefonti V et al (2012) A meta-analysis of coffee consumption and pancreatic cancer. Ann Oncol 2:311–318CrossRef

Braem MG, Onland-Moret NC, Schouten LJ et al (2012) Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis. Am J Clin Nutr 95:1172–1181PubMedCrossRef

10.

Veierød MB, Thelle DS, Laake P (1997) Diet and risk of cutaneous malignant melanoma: a prospective study of 50,757 Norwegian men and women. Int J Cancer 71:600–604PubMedCrossRef

11.

Osterlind A, Tucker MA, Stone BJ et al (1988) The Danish case-control study of cutaneous malignant melanoma. IV. No association with nutritional factors, alcohol, smoking or hair dyes. Int J Cancer 42:825–828PubMedCrossRef

12.

Green A, Bain C, McLennan R et al (1986) Risk factors for cutaneous melanoma in Queensland. Rec Results Cancer Res 102:76–97CrossRef

13.

Naldi L, Gallus S, Tavani A et al (2004) Oncology Study Group of the Italian Group for Epidemiologic Research in Dermatology. Risk of melanoma and vitamin A coffee and alcohol: a case-control study from Italy. Eur J Cancer Prev 13:503–508PubMedCrossRef

14.

Dong LM, Potter JD, White E et al (2008) Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA 299:2423–2436PubMedCrossRef

15.

Parl FF (2005) Glutathione S-transferase genotypes and cancer risk. Cancer Lett 221:123–129PubMedCrossRef

16.

Huber WW, Parzefall W (2005) Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods Enzymol 401:307–341PubMedCrossRef

17.

English DR, Mac Lennan R (1990) Epidemiological studies of melanocytic naevi protocol for identifying and recording naevi. IARC internal report no 90/002. International Agency for Research on Cancer, Lyon

18.

Freedberg IM et al (eds) (1999) Fitzpatrick’s dermatology in general medicine, 5th edn. McGraw-Hill, New York

19.

Leffondré K, Abrahamowicz M, Siemiatycki J et al (2002) Modeling smoking history: a comparison of different approaches. Am J Epidemiol 156:813–823PubMedCrossRef

20.

Fortes C, Forastiere F, Farchi S et al (2003) The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer 46:30–37PubMedCrossRef

21.

Gao Y, Zhang Q (1999) Polimorphisms of the GSTM1 and CYP2D6 genes associated with susceptibility to lung cancer in Chinese. Mutat Res 444:441–449PubMedCrossRef

22.

Fortes C, Mastroeni S, Melchi F et al (2007) The association between residential pesticide use and cutaneous melanoma. Eur J Cancer 43:1066–1075PubMedCrossRef

23.

Denkert C, Kobel M, Berger S et al (2001) Expression of cyclooxygenase 2 in human malignant melanoma. Cancer Res 61:303–308PubMed

24.

Tabolacci C, Lentini A, Provenzano B et al (2010) Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells. Melanoma Res 20:273–279PubMedCrossRef

25.

Kang NJ, Lee KW, Shin BJ et al (2009) Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis 30:321–330PubMedCrossRef

26.

Lee WJ, Zhu BT (2006) Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols. Carcinogenesis 27:269–277PubMedCrossRef

27.

Lee KJ, Jeong HG (2007) Protective effects of kahweol and cafestol against hydrogen peroxide-induced oxidative stress and DNA damage. Toxicol Lett 173:80–87PubMedCrossRef

28.

Yamada Y, Yasui H, Sakurai H (2006) Suppressive effect of caffeic acid and its derivatives on the generation of UVA-induced reactive oxygen species in the skin of hairless mice and pharmacokinetic analysis on organ distribution of caffeic acid in ddY mice. Photochem Photobiol 82:1668–1676PubMed

29.

Armstrong BK, White E, Saracci R (1992) Principles of exposure measurement in epidemiology. Oxford University Press, New York

30.

Lampe JW (2009) Interindividual differences in response to plant-based diets: implications for cancer risk. Am J Clin Nutr 89:1553S–1557SPubMedCrossRef

31.

Mössner R, Anders N, König IR et al (2007) Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma. Arch Dermatol Res 298:371–379PubMedCrossRef

32.

Chan EC, Lam SY, Fu KH et al (2005) Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet 162:10–20PubMedCrossRef

33.

Ibarrola-Villava M, Martin-Gonzalez M, Lazaro P et al (2012) Role of glutathione S-transferases in melanoma susceptibility: association with GSTP1 rs1695 polymorphism. Br J Dermatol 166:1176–1183PubMedCrossRef

34.

Heagerty A, Smith A, English J et al (1994) Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet 343:266–268PubMedCrossRef

35.

Kanetsky PA, Holmes R, Walker A et al (2001) Interaction of glutathione S-transferase M1 and T1 genotypes and malignant melanoma. Cancer Epidemiol Biomark Prev 10:509–513

36.

Fortes C, Mastroeni S, Boffetta P et al (2011) Polymorphisms of GSTM1 and GSTT1, sun exposure and the risk of melanoma: a case–control study. Acta Derm Venereol 91:284–289PubMedCrossRef

37.

Palli D, Masala G, Peluso M et al (2004) The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects. Carcinogenesis 25:577–584PubMedCrossRef

38.

Lampe JW, Chen C, Li S et al (2000) Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 9:787–793PubMed

39.

Epplein M, Wilkens LR, Tiirikainen M et al (2009) Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev 18:314–320PubMedCrossRef

40.

Gervasini G, San Jose C, Carrillo JA et al (2010) GST polymorphisms interact with dietary factors to modulate lung cancer risk: study in a high-incidence area. Nutr Cancer 62:750–758PubMedCrossRef

41.

Borst L, Buchard A, Rosthøj S et al (2012) Gene dose effects of GSTM1, GSTT1 and GSTP1 polymorphisms on outcome in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 34:38–42PubMedCrossRef

42.

Coles BF, Kadlubar FF (2003) Detoxification of electrophilic compounds by glutathione S-transferase catalysis:determinants of individual response to chemical carcinogens and chemotherapeutic drugs. BioFactors 17:115–130PubMedCrossRef

Title: The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms
Authors: Cristina Fortes
Simona Mastroeni
Paolo Boffetta
Gianluca Antonelli
Maria Antonietta Pilla
Giordano Bottà
Patrizia Anzidei
Federica Venanzetti
Publication date: 01-10-2013
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 10/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0255-4

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Abstract

Purposes

Methods

Results

Conclusions

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