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Cancer Causes & Control

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01-02-2011 | Brief report

Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study

Authors: G. David Batty, Mika Kivimäki, Robert Clarke, George Davey Smith, Martin J. Shipley

Published in: Cancer Causes & Control | Issue 2/2011

Abstract

Background

The determinants of prostate cancer––aside from established but non-modifiable risk factors of increased age, black ethnicity, and a positive family history––are poorly understood.

Methods

We examined the association of a series of baseline socioeconomic, behavioral, and metabolic characteristics with the risk of prostate cancer mortality in a 40-year follow-up of study members from the original Whitehall cohort study. During this period there were 578 prostate cancer deaths in 17,934 men.

Results

After adjustment for a series of baseline covariates, results from proportional hazards regression analyses indicated that marital status (hazard ratio; 95% confidence interval: widowed/divorced vs. married: 1.44; 0.95, 2.18), raised blood cholesterol (tertile 3 vs. 1: 1.35; 1.11, 1.65), and increased physical stature (tertile 3 vs. 1: 1.37; 1.09, 1.74) were associated with death from prostate cancer, although statistical significance at conventional levels was not apparent in all analyses. There was no evidence that physical activity, smoking habit, socio-economic status, component of either blood pressure or diabetes predicted the risk of death from this malignancy herein.

Conclusions

In the present study, there was a suggestion that marital status, blood cholesterol, and height were risk indices for death from prostate cancer.

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Title: Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study
Authors: G. David Batty
Mika Kivimäki
Robert Clarke
George Davey Smith
Martin J. Shipley
Publication date: 01-02-2011
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 2/2011
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9691-6

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Abstract

Background

Methods

Results

Conclusions

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