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Cancer Causes & Control
Published in: Cancer Causes & Control 12/2010

01-12-2010 | Original paper

Physical activity, body size and composition, and risk of ovarian cancer

Authors: Fiona Chionh, Laura Baglietto, Kavitha Krishnan, Dallas R. English, Robert J. MacInnis, Dorota M. Gertig, John L. Hopper, Graham G. Giles

Published in: Cancer Causes & Control | Issue 12/2010

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Abstract

Objectives

We examined the association between risk of ovarian cancer and physical activity and anthropometry (body mass index, height, waist, fat, and fat-free mass) in the Melbourne Collaborative Cohort Study.

Methods

This prospective cohort study included 18,700 women aged 26–76 years old at recruitment between 1990 and 1994. Participants were interviewed about their physical activity, including frequency and intensity. Body measurements were taken directly; fat mass and fat-free mass were calculated from bioelectrical impedance analysis. During an average of 10.2 years of follow-up, 113 ovarian cancers were ascertained. Cox regression was used to estimate hazard ratios.

Results

After adjusting for potential confounders, compared with no physical activity, the hazard ratios for levels of total physical activity were 1.56 (95% CI: 0.81, 3.00) for low level, 1.92 (1.07, 3.45) for medium level, and 2.21 (1.16, 4.24) for high level (test for trend, p = 0.01). The hazard ratio for ovarian cancer in relation to BMI was 1.22 (95% CI: 1.00, 1.48; p-trend, 0.06) per 5 kg/m2 increment, and for fat mass, 1.23 (95% CI: 1.01, 1.49; p-trend, 0.04) per 10 kg increment.

Conclusions

This study found some evidence for a possible relationship between higher levels of physical activity and body size and increased ovarian cancer risk.
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Metadata
Title
Physical activity, body size and composition, and risk of ovarian cancer
Authors
Fiona Chionh
Laura Baglietto
Kavitha Krishnan
Dallas R. English
Robert J. MacInnis
Dorota M. Gertig
John L. Hopper
Graham G. Giles
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 12/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9638-y

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