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Open Access 01-03-2010 | Original paper

Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men

Authors: Jean Y. Tang, Neeta Parimi, Angela Wu, W. John Boscardin, James M. Shikany, Mary-Margaret Chren, Steven R. Cummings, Ervin H. Epstein Jr., Douglas C. Bauer, for the Osteoporotic Fractures in Men (MrOS) Study Group

Published in: Cancer Causes & Control | Issue 3/2010

Abstract

To determine the relationship between 25(OH) vitamin D levels and non-melanoma skin cancer (NMSC), we performed a nested case–control study in ambulatory, elderly men enrolled in the Osteoporotic Fractures in Men (MrOS) Study. Health habit and medical history, including self-reported history of NMSC were recorded and 25(OH)D levels were measured on serum collected at baseline from a random sample of Caucasian MrOS subjects. Mean age (73 ± 5), BMI, daily vitamin D and calcium intake were similar in the men with (n = 178) and without NMSC (n = 930), but higher levels of 25(OH)D were associated with a decreased risk of having a history of NMSC (P _trend = 0.04). Men in the highest quintile of 25(OH)D (>30 ng/mL) had 47% lower odds of NMSC (95% CI: 0.30–0.93, p = 0.026) compared to those in the lowest quintile. Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.

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Title: Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men
Authors: Jean Y. Tang
Neeta Parimi
Angela Wu
W. John Boscardin
James M. Shikany
Mary-Margaret Chren
Steven R. Cummings
Ervin H. Epstein Jr.
Douglas C. Bauer
for the Osteoporotic Fractures in Men (MrOS) Study Group
Publication date: 01-03-2010
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 3/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-009-9470-4

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