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01-05-2007 | Brief Report

Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

Authors: Daniele Campa, Mia Hashibe, David Zaridze, Neonila Szeszenia-Dabrowska, Ioan Nicolae Mates, Vladimir Janout, Ivana Holcatova, Eleonóra Fabiánová, Valérie Gaborieau, Rayjean J. Hung, Paolo Boffetta, Paul Brennan, Federico Canzian

Published in: Cancer Causes & Control | Issue 4/2007

Abstract

Objectives

The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).

Methods

We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case–control study comprising 811 UADT cancer cases and 1,083 controls.

Results

An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19–4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50–0.98) for carriers of the minor allele.

Conclusions

To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

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Title: Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract
Authors: Daniele Campa
Mia Hashibe
David Zaridze
Neonila Szeszenia-Dabrowska
Ioan Nicolae Mates
Vladimir Janout
Ivana Holcatova
Eleonóra Fabiánová
Valérie Gaborieau
Rayjean J. Hung
Paolo Boffetta
Paul Brennan
Federico Canzian
Publication date: 01-05-2007
Publisher: Kluwer Academic Publishers
Published in: Cancer Causes & Control / Issue 4/2007
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-007-0129-8

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Abstract

Objectives

Methods

Results

Conclusions

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