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Open Access 01-11-2015 | Original Paper

MEG–EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy

Authors: Rasheda Arman Chowdhury, Younes Zerouali, Tanguy Hedrich, Marcel Heers, Eliane Kobayashi, Jean-Marc Lina, Christophe Grova

Published in: Brain Topography | Issue 6/2015

Abstract

The purpose of this study is to develop and quantitatively assess whether fusion of EEG and MEG (MEEG) data within the maximum entropy on the mean (MEM) framework increases the spatial accuracy of source localization, by yielding better recovery of the spatial extent and propagation pathway of the underlying generators of inter-ictal epileptic discharges (IEDs). The key element in this study is the integration of the complementary information from EEG and MEG data within the MEM framework. MEEG was compared with EEG and MEG when localizing single transient IEDs. The fusion approach was evaluated using realistic simulation models involving one or two spatially extended sources mimicking propagation patterns of IEDs. We also assessed the impact of the number of EEG electrodes required for an efficient EEG–MEG fusion. MEM was compared with minimum norm estimate, dynamic statistical parametric mapping, and standardized low-resolution electromagnetic tomography. The fusion approach was finally assessed on real epileptic data recorded from two patients showing IEDs simultaneously in EEG and MEG. Overall the localization of MEEG data using MEM provided better recovery of the source spatial extent, more sensitivity to the source depth and more accurate detection of the onset and propagation of IEDs than EEG or MEG alone. MEM was more accurate than the other methods. MEEG proved more robust than EEG and MEG for single IED localization in low signal-to-noise ratio conditions. We also showed that only few EEG electrodes are required to bring additional relevant information to MEG during MEM fusion.

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The center of head was defined with the fiducial points marked during EEG/MEG acquisition. It is the point which is equidistant to the left and right peri-auricular points, at the same height of the location of the nasion.

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Title: MEG–EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy
Authors: Rasheda Arman Chowdhury
Younes Zerouali
Tanguy Hedrich
Marcel Heers
Eliane Kobayashi
Jean-Marc Lina
Christophe Grova
Publication date: 01-11-2015
Publisher: Springer US
Published in: Brain Topography / Issue 6/2015
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-015-0437-3

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MEG–EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy

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