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Open Access 01-03-2015 | Original Paper

Ultra-Rapid Access to Words in Chronic Aphasia: The Effects of Intensive Language Action Therapy (ILAT)

Authors: Lucy J. MacGregor, Stephanie Difrancesco, Friedemann Pulvermüller, Yury Shtyrov, Bettina Mohr

Published in: Brain Topography | Issue 2/2015

Abstract

Effects of intensive language action therapy (ILAT) on automatic language processing were assessed using Magnetoencephalography (MEG). Auditory magnetic mismatch negativity (MMNm) responses to words and pseudowords were recorded in twelve patients with chronic aphasia before and immediately after two weeks of ILAT. Following therapy, Patients showed significant clinical improvements of auditory comprehension as measured by the Token Test and in word retrieval and naming as measured by the Boston Naming Test. Neuromagnetic responses dissociated between meaningful words and meaningless word-like stimuli ultra-rapidly, approximately 50 ms after acoustic information first allowed for stimulus identification. Over treatment, there was a significant increase in the left-lateralisation of this early word-elicited activation, observed in perilesional fronto-temporal regions. No comparable change was seen for pseudowords. The results may reflect successful, therapy-induced, language restitution in the left hemisphere.

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Title: Ultra-Rapid Access to Words in Chronic Aphasia: The Effects of Intensive Language Action Therapy (ILAT)
Authors: Lucy J. MacGregor
Stephanie Difrancesco
Friedemann Pulvermüller
Yury Shtyrov
Bettina Mohr
Publication date: 01-03-2015
Publisher: Springer US
Published in: Brain Topography / Issue 2/2015
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-014-0398-y

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Ultra-Rapid Access to Words in Chronic Aphasia: The Effects of Intensive Language Action Therapy (ILAT)

Abstract

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Abstract

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