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01-01-2015 | Review

Motor Abnormalities and Basal Ganglia in Schizophrenia: Evidence from Structural Magnetic Resonance Imaging

Authors: Dusan Hirjak, Robert C. Wolf, Einar P. Wilder-Smith, Katharina M. Kubera, Philipp A. Thomann

Published in: Brain Topography | Issue 1/2015

Abstract

At the beginning of the twentieth century, many authors proposed that a considerable number of schizophrenic patients experience genuine motor abnormalities (GMA). In the era of antipsychotic treatment, GMA became a scientifically and clinically challenging characteristic of schizophrenia. Over the past 10 years, several magnetic resonance imaging (MRI) studies suggested a crucial role of the motor system in this disorder. Constituting a major relay center in the extrapyramidal motor system and being involved in the automatic execution of motor plans, an involvement of the basal ganglia with GMA and schizophrenia is plausible. However, the precise morphological correlates of GMA have remained controversial. The aim of this paper is to systematically review structural neuroimaging findings on GMA and basal ganglia in individuals with schizophrenia. Nineteen structural MRI studies were identified for inclusion in the review. Considering the extant data, there is some evidence for volumetric and shape alterations of basal ganglia in schizophrenia being in part determined by psychopathology and GMA, and not entirely explained by antipsychotic medication effects.

Andreasen NC, Paradiso S, O’Leary DS (1998) “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr Bull 24(2):203–218PubMed

Arango C, Kirkpatrick B, Buchanan RW (2000) Neurological signs and the heterogeneity of schizophrenia. Am J Psychiatry 157(4):560–565PubMed

Ashburner J, Friston KJ (2000) Voxel-based morphometry–the methods. NeuroImage 11(6 Pt 1):805–821PubMed

Bai YM, Chou KH, Lin CP, Chen IY, Li CT, Yang KC et al (2009) White matter abnormalities in schizophrenia patients with tardive dyskinesia: a diffusion tensor image study. Schizophr Res 109(1–3):167–181PubMed

Basser PJ, Mattiello J, LeBihan D (1994) Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 103(3):247–254PubMed

Bernard JA, Dean DJ, Kent JS, Orr JM, Pelletier-Baldelli A, Lunsford-Avery JR et al (2014) Cerebellar networks in individuals at ultra high-risk of psychosis: impact on postural sway and symptom severity. Hum Brain Mapp. doi:10.1002/hbm.22458

Biswas P, Malhotra S, Malhotra A, Gupta N (2007) Comparative study of neurological soft signs in schizophrenia with onset in childhood, adolescence and adulthood. Acta Psychiatr Scand 115(4):295–303PubMed

Blanchet PJ, Normandeau L, Rompre PH (2012) Comparing three screening tools for drug-induced parkinsonism in patients with advanced schizophrenia: a pilot study. Schizophr Res 137(1–3):230–233PubMed

Bleuler E (1950) Dementia praecox or the group of schizophrenias. Zinkin J, trans. International Universities Press, New York

Bolton D, Gibb W, Lees A, Raven P, Gray JA, Chen E et al (1998) Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia. Behav Neurol 11(4):197–204PubMed

Bombin I, Arango C, Buchanan RW (2005) Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophr Bull 31(4):962–977PubMed

Bottmer C, Bachmann S, Pantel J, Essig M, Amann M, Schad LR et al (2005) Reduced cerebellar volume and neurological soft signs in first-episode schizophrenia. Psychiatry Res 140(3):239–250PubMed

Bracht T, Schnell S, Federspiel A, Razavi N, Horn H, Strik W et al (2013) Altered cortico-basal ganglia motor pathways reflect reduced volitional motor activity in schizophrenia. Schizophr Res 143(2–3):269–276PubMed

Buchanan RW, Heinrichs DW (1989) The neurological evaluation scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 27(3):335–350PubMed

Buchanan RW, Kirkpatrick B, Heinrichs DW, Carpenter WT Jr (1990) Clinical correlates of the deficit syndrome of schizophrenia. Am J Psychiatry 147(3):290–294PubMed

Buchanan RW, Breier A, Kirkpatrick B, Elkashef A, Munson RC, Gellad F et al (1993) Structural abnormalities in deficit and nondeficit schizophrenia. Am J Psychiatry 150(1):59–65PubMed

Cannon M, Jones P, Huttunen MO, Tanskanen A, Huttunen T, Rabe-Hesketh S et al (1999) School performance in Finnish children and later development of schizophrenia: a population-based longitudinal study. Arch Gen Psychiatry 56(5):457–463PubMed

Carpenter WT Jr, Heinrichs DW, Wagman AM (1988) Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry 145(5):578–583PubMed

Chakravarthy VS, Joseph D, Bapi RS (2010) What do the basal ganglia do? A modeling perspective. Biol Cybern 103(3):237–253PubMed

Chan RC, Gottesman II (2008) Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star? Neurosci Biobehav Rev 32(5):957–971PubMed

Chan WY, Chia MY, Yang GL, Woon PS, Sitoh YY, Collinson SL et al (2009) Duration of illness, regional brain morphology and neurocognitive correlates in schizophrenia. Ann Acad Med Singapore 38(5):388–395PubMed

Chan RC, Xu T, Heinrichs RW, Yu Y, Wang Y (2010) Neurological soft signs in schizophrenia: a meta-analysis. Schizophr Bull 36(6):1089–1104PubMedCentralPubMed

Chen EY, Lam LC, Chen RY, Nguyen DG (1996) Negative symptoms, neurological signs and neuropsychological impairments in 204 Hong Kong Chinese patients with schizophrenia. Br J Psychiatry 168(2):227–233PubMed

Chen YL, Chen YH, Mak FL (2000) Soft neurological signs in schizophrenic patients and their nonpsychotic siblings. J Nerv Ment Dis 188(2):84–89PubMed

Cox SM, Ludwig AM (1979) Neurological soft signs and psychopathology. I. Findings in schizophrenia. J Nerv Ment Dis 167(3):161–165PubMed

Cuesta MJ, Sanchez-Torres AM, de Jalon EG, Campos MS, Ibanez B, Moreno-Izco L et al (2013) Spontaneous parkinsonism is associated with cognitive impairment in antipsychotic-naive patients with first-episode psychosis: a 6-month follow-up study. Schizophr Bull 33(3):438–440

D’Agati E, Casarelli L, Pitzianti M, Pasini A (2012) Neuroleptic treatments and overflow movements in schizophrenia: are they independent? Psychiatry Res 200(2–3):970–976PubMed

Dazzan P, Morgan KD, Orr KG, Hutchinson G, Chitnis X, Suckling J et al (2004) The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study. Brain 127(Pt 1):143–153PubMed

Dazzan P, Morgan KD, Chitnis X, Suckling J, Morgan C, Fearon P et al (2006) The structural brain correlates of neurological soft signs in healthy individuals. Cereb Cortex 16(8):1225–1231PubMed

Docx L, Morrens M, Bervoets C, Hulstijn W, Fransen E, De Hert M et al (2012) Parsing the components of the psychomotor syndrome in schizophrenia. Acta Psychiatr Scand 126(4):256–265PubMed

Duff BJ, Macritchie KA, Moorhead TW, Lawrie SM, Blackwood DH (2013) Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review. Schizophr Res 147(1):1–13PubMed

Ebdrup BH, Skimminge A, Rasmussen H, Aggernaes B, Oranje B, Lublin H et al (2011) Progressive striatal and hippocampal volume loss in initially antipsychotic-naive, first-episode schizophrenia patients treated with quetiapine: relationship to dose and symptoms. Int J Neuropsychopharmacol 14(1):69–82PubMed

Elkashef AM, Buchanan RW, Gellad F, Munson RC, Breier A (1994) Basal ganglia pathology in schizophrenia and tardive dyskinesia: an MRI quantitative study. Am J Psychiatry 151(5):752–755PubMed

Fenton WS, Blyler CR, Wyatt RJ, McGlashan TH (1997) Prevalence of spontaneous dyskinesia in schizophrenic and non-schizophrenic psychiatric patients. Br J Psychiatry 171:265–268PubMed

FinK M (2013) Rediscovering catatonia: the biography of a treatable syndrome. Acta Psychiatr Scand Suppl 441:1–47PubMed

Fink M, Taylor MA (2009) The catatonia syndrome: forgotten but not gone. Arch Gen Psychiatry 66(11):1173–1177PubMed

Fink M, Shorter E, Taylor MA (2010) Catatonia is not schizophrenia: Kraepelin’s error and the need to recognize catatonia as an independent syndrome in medical nomenclature. Schizophr Bull 36(2):314–320PubMedCentralPubMed

Fischer BA, Keller WR, Arango C, Pearlson GD, McMahon RP, Meyer WA et al (2012) Cortical structural abnormalities in deficit versus nondeficit schizophrenia. Schizophr Res 136(1–3):51–54PubMedCentralPubMed

Friedman JH (2004) Historical perspective on movement disorders. J Clin Psychiatry 65(Suppl 9):3–8PubMed

Fritzsche KH, Neher PF, Reicht I, van Bruggen T, Goch C, Reisert M et al (2012) MITK diffusion imaging. Methods Inf Med 51(5):441–448PubMed

Galderisi S, Maj M (2009) Deficit schizophrenia: an overview of clinical, biological and treatment aspects. Eur Psychiatry 24(8):493–500PubMed

Galderisi S, Maj M, Mucci A, Cassano GB, Invernizzi G, Rossi A et al (2002) Historical, psychopathological, neurological, and neuropsychological aspects of deficit schizophrenia: a multicenter study. Am J Psychiatry 159(6):983–990PubMed

Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G et al (2008) Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia. Schizophr Bull 34(2):393–401PubMedCentralPubMed

Gay O, Plaze M, Oppenheim C, Mouchet-Mages S, Gaillard R, Olie JP et al (2012) Cortex morphology in first-episode psychosis patients with neurological soft signs. Schizophr Bull 39(4):820–829PubMedCentralPubMed

Genovese CR, Lazar NA, Nichols T (2002) Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 15(4):870–878PubMed

Glenthoj A, Glenthoj BY, Mackeprang T, Pagsberg AK, Hemmingsen RP, Jernigan TL et al (2007) Basal ganglia volumes in drug-naive first-episode schizophrenia patients before and after short-term treatment with either a typical or an atypical antipsychotic drug. Psychiatry Res 154(3):199–208PubMed

Halliday J, Farrington S, Macdonald S, MacEwan T, Sharkey V, McCreadie R (2002) Nithsdale schizophrenia surveys 23: movement disorders. 20-year review. Br J Psychiatry 181:422–427PubMed

Hartberg CB, Sundet K, Rimol LM, Haukvik UK, Lange EH, Nesvag R et al (2011) Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls. Prog Neuropsychopharmacol Biol Psychiatry 35(4):1122–1130PubMed

Heinrichs DW, Buchanan RW (1988) Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry 145(1):11–18PubMed

Hertzig ME, Birch HG (1968) Neurologic organization in psychiatrically disturbed adolescents. A comparative consideration of sex differences. Arch Gen Psychiatry 19(5):528–537PubMed

Heuser M, Thomann PA, Essig M, Bachmann S, Schroder J (2011) Neurological signs and morphological cerebral changes in schizophrenia: an analysis of NSS subscales in patients with first episode psychosis. Psychiatry Res 192(2):69–76PubMed

Hirjak D, Wolf RC, Stieltjes B, Seidl U, Schroder J, Thomann PA (2012) Neurological soft signs and subcortical brain morphology in recent onset schizophrenia. J Psychiatr Res 46(4):533–539PubMed

Hirjak D, Wolf RC, Stieltjes B, Hauser T, Seidl U, Schroder J et al (2014) Cortical signature of neurological soft signs in recent onset schizophrenia. Brain Topogr 27(2):296–306PubMed

Jaafari N, Baup N, Bourdel MC, Olie JP, Rotge JY, Wassouf I et al (2011) Neurological soft signs in OCD patients with early age at onset, versus patients with schizophrenia and healthy subjects. J Neuropsychiatry Clin Neurosci 23(4):409–416PubMed

Jahn T, Hubmann W, Karr M, Mohr F, Schlenker R, Heidenreich T et al (2006) Motoric neurological soft signs and psychopathological symptoms in schizophrenic psychoses. Psychiatry Res 142(2–3):191–199PubMed

Janssen J, Diaz-Caneja A, Reig S, Bombin I, Mayoral M, Parellada M et al (2009) Brain morphology and neurological soft signs in adolescents with first-episode psychosis. Br J Psychiatry 195(3):227–233PubMed

Jaspers K (1965) Allgemeine Psychopathologie, (8. Auflage ed.). Springer, Berlin

Kahlbaum KL (1874) Die Katatonie oder das Spannungsirresein. Verlag August Hirschwald, Berlin

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261–276

Kennard MA (1960) Value of equivocal signs in neurologic diagnosis. Neurology 10:753–764PubMed

Keshavan MS, Sanders RD, Sweeney JA, Diwadkar VA, Goldstein G, Pettegrew JW et al (2003) Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychoses. Am J Psychiatry 160(7):1298–1304PubMed

Kinney DK, Yurgelun-Todd DA, Woods BT (1999) Neurologic signs of cerebellar and cortical sensory dysfunction in schizophrenics and their relatives. Schizophr Res 35(2):99–104PubMed

Kirkpatrick B, Buchanan RW, McKenney PD, Alphs LD, Carpenter WT Jr (1989) The schedule for the deficit syndrome: an instrument for research in schizophrenia. Psychiatry Res 30(2):119–123PubMed

Kong L, Bachmann S, Thomann PA, Essig M, Schroder J (2012) Neurological soft signs and gray matter changes: a longitudinal analysis in first-episode schizophrenia. Schizophr Res 134(1):27–32PubMed

Koning JP, Tenback DE, van Os J, Aleman A, Kahn RS, van Harten PN (2010) Dyskinesia and parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis. Schizophr Bull 36(4):723–731PubMedCentralPubMed

Kraepelin EP (1971) Dementia praecox and paraphrenia, (Robertson GM, Trans.). Robert E. Krieger Publishing Co Inc., Huntington

Kreapelin E (1913) Psychiatrie. Ein Lehrbuch. 8. Aufl. (vol. Bd. 3, Teil 2.). Barth, Leipzig

Krebs MO, Gut-Fayand A, Bourdel M, Dischamp J, Olie J (2000) Validation and factorial structure of a standardized neurological examination assessing neurological soft signs in schizophrenia. Schizophr Res 45(3):245–260PubMed

Lang DJ, Kopala LC, Vandorpe RA, Rui Q, Smith GN, Goghari VM et al (2001) An MRI study of basal ganglia volumes in first-episode schizophrenia patients treated with risperidone. Am J Psychiatry 158(4):625–631PubMed

Lawrie SM, Byrne M, Miller P, Hodges A, Clafferty RA, Cunningham Owens DG et al (2001) Neurodevelopmental indices and the development of psychotic symptoms in subjects at high risk of schizophrenia. Br J Psychiatry 178:524–530PubMed

Leisman G, Melillo R (2012) The basal ganglia: motor and cognitive relationships in a clinical neurobehavioral context. Rev Neurosci 24(1):9–25

Leisman G, Braun-Benjamin O, Melillo R (2014) Cognitive-motor interactions of the basal ganglia in development. Front Syst Neurosci 8:16PubMedCentralPubMed

Li CT, Chou KH, Su TP, Huang CC, Chen MH, Bai YM et al (2013) Gray matter abnormalities in schizophrenia patients with tardive dyskinesia: a magnetic resonance imaging voxel-based morphometry study. PLoS One 8(8):e71034PubMedCentralPubMed

Marcus J, Hans SL, Lewow E, Wilkinson L, Burack CM (1985) Neurological findings in high-risk children: childhood assessment and 5-year followup. Schizophr Bull 11(1):85–100PubMed

Massana G, Salgado-Pineda P, Junque C, Perez M, Baeza I, Pons A et al (2005) Volume changes in gray matter in first-episode neuroleptic-naive schizophrenic patients treated with risperidone. J Clin Psychopharmacol 25(2):111–117PubMed

McCreadie RG, Thara R, Padmavati R, Srinivasan TN, Jaipurkar SD (2002) Structural brain differences between never-treated patients with schizophrenia, with and without dyskinesia, and normal control subjects: a magnetic resonance imaging study. Arch Gen Psychiatry 59(4):332–336PubMed

Middleton FA, Strick PL (2000) Basal ganglia output and cognition: evidence from anatomical, behavioral, and clinical studies. Brain Cogn 42(2):183–200PubMed

Mion CC, Andreasen NC, Arndt S, Swayze VW 2nd, Cohen GA (1991) MRI abnormalities in tardive dyskinesia. Psychiatry Res 40(3):157–166PubMed

Mittal VA, Walker EF (2007) Movement abnormalities predict conversion to Axis I psychosis among prodromal adolescents. J Abnorm Psychol 116(4):796–803PubMed

Mittal VA, Dhruv S, Tessner KD, Walder DJ, Walker EF (2007a) The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. Biol Psychiatry 61(10):1179–1186PubMed

Mittal VA, Tessner KD, Trottman HD, Esterberg M, Dhrub SH, Simeonova DI et al (2007b) Movement abnormalities and the progression of prodromal symptomatology in adolescents at risk for psychotic disorders. J Abnorm Psychol 116(2):260–267PubMed

Mittal VA, Daley M, Shiode MF, Bearden CE, O’Neill J, Cannon TD (2010) Striatal volumes and dyskinetic movements in youth at high-risk for psychosis. Schizophr Res 123(1):68–70PubMedCentralPubMed

Mittal VA, Dean DJ, Bernard JA, Orr JM, Pelletier-Baldelli A, Carol EE et al (2013) Neurological soft signs predict abnormal cerebellar-thalamic tract development and negative symptoms in adolescents at high risk for psychosis: a longitudinal perspective. Schizophr Bull. doi:10.1093/schbul/sbt199

Mohr F, Hubmann W, Cohen R, Bender W, Haslacher C, Honicke S et al (1996) Neurological soft signs in schizophrenia: assessment and correlates. Eur Arch Psychiatry Clin Neurosci 246(5):240–248PubMed

Morrens M, Hulstijn W, Sabbe B (2007) Psychomotor slowing in schizophrenia. Schizophr Bull 33(4):1038–1053PubMedCentralPubMed

Mouchet-Mages S, Rodrigo S, Cachia A, Mouaffak F, Olie JP, Meder JF et al (2011) Correlations of cerebello-thalamo-prefrontal structure and neurological soft signs in patients with first-episode psychosis. Acta Psychiatr Scand 123(6):451–458PubMed

Murray GK, Jones PB, Moilanen K, Veijola J, Miettunen J, Cannon TD et al (2006) Infant motor development and adult cognitive functions in schizophrenia. Schizophr Res 81(1):65–74PubMed

Northoff G, Koch A, Wenke J, Eckert J, Boker H, Pflug B et al (1999) Catatonia as a psychomotor syndrome: a rating scale and extrapyramidal motor symptoms. Mov Disord 14(3):404–416PubMed

Owens DG (1985) Involuntary disorders of movement in chronic schizophrenia–the role of the illness and its treatment. Psychopharmacology Suppl 2:79–87PubMed

Oyebode F (2008) Sims’ symptoms in the mind: an introduction to descriptive psychopathology, 4th edn. Saunders Elsevier, Philadelphia

Pappa S, Dazzan P (2009) Spontaneous movement disorders in antipsychotic-naive patients with first-episode psychoses: a systematic review. Psychol Med 39(7):1065–1076PubMed

Patel N, Jankovic J, Hallett M (2014) Sensory aspects of movement disorders. Lancet Neurol 13(1):100–112PubMed

Patenaude B, Smith S, Kennedy D, Jenkinson M (2011) A bayesian model of shape and appearance for subcortical brain segmentation. NeuroImage 56(3):907–922PubMedCentralPubMed

Peralta V, Cuesta MJ (2001) Motor features in psychotic disorders. I. Factor structure and clinical correlates. Schizophr Res 47(2–3):107–116PubMed

Peralta V, Cuesta MJ (2011) Neuromotor abnormalities in neuroleptic-naive psychotic patients: antecedents, clinical correlates, and prediction of treatment response. Compr Psychiatry 52(2):139–145PubMed

Peralta V, Campos MS, De Jalon EG, Cuesta MJ (2010) Motor behavior abnormalities in drug-naive patients with schizophrenia spectrum disorders. Mov Disord 25(8):1068–1076PubMed

Peralta V, Basterra V, Campos MS, de Jalon EG, Moreno-Izco L, Cuesta MJ (2012a) Characterization of spontaneous parkinsonism in drug-naive patients with nonaffective psychotic disorders. Eur Arch Psychiatry Clin Neurosci 262(2):131–138PubMed

Peralta V, Moreno-Izco L, Sanchez-Torres A, Garcia de Jalon E, Campos MS, Cuesta MJ (2012b) Characterization of the deficit syndrome in drug-naive schizophrenia patients: the role of spontaneous movement disorders and neurological soft signs. Schizophr Bull 40(1):214–224PubMedCentralPubMed

Peralta V, de Jalon EG, Campos MS, Cuesta MJ (2013) Phenomenological differences between spontaneous and drug-related extrapyramidal syndromes in patients with schizophrenia-spectrum disorders. J Clin Psychopharmacol 33(3):438–440PubMed

Phal PM, Usmanov A, Nesbit GM, Anderson JC, Spencer D, Wang P et al (2008) Qualitative comparison of 3-T and 1.5-T MRI in the evaluation of epilepsy. Am J Roentgenol 191(3):890–895

Rigucci S, Dimitri-Valente G, Mandarelli G, Manfredi G, Comparelli A, Filippis SD et al (2014) Neurological soft signs discriminate schizophrenia from bipolar disorder. J Psychiatr Pract 20(2):147–153PubMed

Rochford JM, Detre T, Tucker GJ, Harrow M (1970) Neuropsychological impairments in functional psychiatric diseases. Arch Gen Psychiatry 22(2):114–119PubMed

Rogers D (1985) The motor disorders of severe psychiatric illness: a conflict of paradigms. Br J Psychiatry 147:221–232

Sarro S, Pomarol-Clotet E, Canales-Rodriguez EJ, Salvador R, Gomar JJ, Ortiz-Gil J et al (2012) Structural brain changes associated with tardive dyskinesia in schizophrenia. Br J Psychiatry 203(1):51–57PubMed

Scherk H, Falkai P (2006) Effects of antipsychotics on brain structure. Curr Opin Psychiatry 19(2):145–150PubMed

Scheuerecker J, Ufer S, Kapernick M, Wiesmann M, Bruckmann H, Kraft E et al (2009) Cerebral network deficits in post-acute catatonic schizophrenic patients measured by fMRI. J Psychiatr Res 43(6):607–614PubMed

Schonecker M (1957) Paroxysmal dyskinesia as the effect of megaphen. Nervenarzt 28(12):550–553PubMed

Schooler NR, Kane JM (1982) Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 39:486–487

Schroder J, Niethammer R, Geider FJ, Reitz C, Binkert M, Jauss M et al (1991) Neurological soft signs in schizophrenia. Schizophr Res 6(1):25–30PubMed

Shenton ME, Dickey CC, Frumin M, McCarley RW (2001) A review of MRI findings in schizophrenia. Schizophr Res 49(1–2):1–52PubMedCentralPubMed

Sigmundsson T, Suckling J, Maier M, Williams S, Bullmore E, Greenwood K et al (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am J Psychiatry 158(2):234–243PubMed

Simpson GM, Lee JH, Zoubok B, Gardos G (1979) A rating scale for tardive dyskinesia. Psychopharmacology 64(2):171–179PubMed

Telfer S, Shivashankar S, Krishnadas R, McCreadie RG, Kirkpatrick B (2011) Tardive dyskinesia and deficit schizophrenia. Acta Psychiatr Scand 124(5):357–362PubMed

Tenback DE, van Harten PN, Slooff CJ, van Os J (2007) Worsening of psychosis in schizophrenia is longitudinally associated with tardive dyskinesia in the European schizophrenia outpatient health outcomes study. Compr Psychiatry 48(5):436–440PubMed

Thomann PA, Roebel M, Dos Santos V, Bachmann S, Essig M, Schroder J (2009a) Cerebellar substructures and neurological soft signs in first-episode schizophrenia. Psychiatry Res 173(2):83–87PubMed

Thomann PA, Wustenberg T, Santos VD, Bachmann S, Essig M, Schroder J (2009b) Neurological soft signs and brain morphology in first-episode schizophrenia. Psychol Med 39(3):371–379PubMed

Ungvari GS, Caroff SN, Gerevich J (2010) The catatonia conundrum: evidence of psychomotor phenomena as a symptom dimension in psychotic disorders. Schizophr Bull 36(2):231–238PubMedCentralPubMed

Venkatasubramanian G, Jayakumar PN, Gangadhar BN, Keshavan MS (2008) Neuroanatomical correlates of neurological soft signs in antipsychotic-naive schizophrenia. Psychiatry Res 164(3):215–222PubMed

Walther S, Strik W (2012) Motor symptoms and schizophrenia. Neuropsychobiology 66(2):77–92PubMed

Whitty PF, Owoeye O, Waddington JL (2009) Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology. Schizophr Bull 35(2):415–424PubMedCentralPubMed

Zhao Q, Li Z, Huang J, Yan C, Dazzan P, Pantelis C et al (2013a) Neurological soft signs are not “soft” in brain structure and functional networks: evidence from ALE meta-analysis. Schizophr Bull 40(3):626–641PubMed

Zhao Q, Ma YT, Lui SS, Liu WH, Xu T, Yu X et al (2013b) Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 43:72–78PubMed

Title: Motor Abnormalities and Basal Ganglia in Schizophrenia: Evidence from Structural Magnetic Resonance Imaging
Authors: Dusan Hirjak
Robert C. Wolf
Einar P. Wilder-Smith
Katharina M. Kubera
Philipp A. Thomann
Publication date: 01-01-2015
Publisher: Springer US
Published in: Brain Topography / Issue 1/2015
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-014-0377-3

2024 ASCO Annual Meeting

Springer Medicine

Motor Abnormalities and Basal Ganglia in Schizophrenia: Evidence from Structural Magnetic Resonance Imaging

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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