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01-07-2013 | Original Paper

Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

Authors: Sang Soo Cho, Giovanna Pellecchia, Kelly Aminian, Nicola Ray, Barbara Segura, Ignacio Obeso, Antonio P. Strafella

Published in: Brain Topography | Issue 3/2013

Abstract

Impulsivity is a complex behaviour composed of different domains encompassing behavioural dis-inhibition, risky decision-making and delay discounting abnormalities. To investigate regional brain correlates between levels of individual impulsivity and grey matter volume, we performed voxel-based morphometric correlation analysis in 34 young, healthy subjects using impulsivity scores measured with Barratt Impulsivity Scale-11 and computerized Kirby’s delay discounting task. The VBM analysis showed that impulsivity appears to be reliant on a network of cortical (medial prefrontal cortex and dorsolateral prefrontal cortex) and subcortical (ventral striatum) structures emphasizing the importance of brain networks associated with reward related decision-making in daily life as morphological biomarkers for impulsivity in a normal healthy population. While our results in healthy volunteers may not directly extend to pathological conditions, they provide an insight into the mechanisms of impulsive behaviour in patients with abnormalities in prefrontal/frontal-striatal connections, such as in drug abuse, pathological gambling, ADHD and Parkinson’s disease.

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Title: Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex
Authors: Sang Soo Cho
Giovanna Pellecchia
Kelly Aminian
Nicola Ray
Barbara Segura
Ignacio Obeso
Antonio P. Strafella
Publication date: 01-07-2013
Publisher: Springer US
Published in: Brain Topography / Issue 3/2013
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-012-0270-x

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Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

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