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01-01-2013 | Brief Communication

A Short-Term Scan–Rescan Reliability Test Measuring Brain Tissue and Subcortical Hyperintensity Volumetrics Obtained Using the Lesion Explorer Structural MRI Processing Pipeline

Authors: Joel Ramirez, Christopher J. M. Scott, Sandra E. Black

Published in: Brain Topography | Issue 1/2013

Abstract

Lesion Explorer (LE) is a reliable and comprehensive MRI-derived tissue segmentation and brain region parcellation processing pipeline for obtaining intracranial tissue and subcortical hyperintensity (SH) volumetrics. The processing pipeline segments: gray (GM) and white matter (WM); sulcal (sCSF) and ventricular cerebrospinal fluid (vCSF); periventricular (pvSH) and deep white subcortical hyperintensities (dwSH); and cystic fluid filled lacunar-like infarcts (Lacunar); into 26 regions of interest. A short-term scan–rescan reliability test was performed on 20 healthy volunteers: 10 older (mean = 77.7 years, SD = 11.1) and 10 younger (mean = 29.4 years, SD = 7.1). Each participant was scanned twice with an average interscan interval of 15.4 days (range: 29 min–50 days). Results suggest low technique-related error as indicated by excellent intraclass correlation coefficient (ICC) results, with ICCs above 0.90 (p < 0.05) for GM, WM, and CSF, in all 26 regions of interest (13 per hemisphere). Ventricular and lesion sub-type (pvSH, dwSH, and Lacunar) volumes also showed high scan–rescan reliability (dwSH = 0.9998, pvSH = 0.9998, Lacunar = 0.9859, p < 0.01). As indicated by the results of this short-term scan–rescan study, the LE structural MRI processing pipeline can be applied for longitudinal volumetric analyses with confidence

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Title: A Short-Term Scan–Rescan Reliability Test Measuring Brain Tissue and Subcortical Hyperintensity Volumetrics Obtained Using the Lesion Explorer Structural MRI Processing Pipeline
Authors: Joel Ramirez
Christopher J. M. Scott
Sandra E. Black
Publication date: 01-01-2013
Publisher: Springer US
Published in: Brain Topography / Issue 1/2013
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-012-0228-z

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A Short-Term Scan–Rescan Reliability Test Measuring Brain Tissue and Subcortical Hyperintensity Volumetrics Obtained Using the Lesion Explorer Structural MRI Processing Pipeline

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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