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01-07-2012 | Original Paper

Behavioural Treatment Increases Activity in the Cognitive Neuronal Networks in Children with Attention Deficit/Hyperactivity Disorder

Authors: Michael Siniatchkin, Nora Glatthaar, Gabriele Gerber von Müller, Alexander Prehn-Kristensen, Stephan Wolff, Silja Knöchel, Elisabeth Steinmann, Anna Sotnikova, Ulrich Stephani, Franz Petermann, Wolf-Dieter Gerber

Published in: Brain Topography | Issue 3/2012

Abstract

Response cost and token approach (RCT) within the scope of a summer camp training is an effective treatment program for attention deficit hyperactivity disorder (ADHD). It is likely that intensive RCT training influences networks responsible for ADHD symptoms. Functional magnetic resonance imaging (fMRI) was carried out in 12 children with ADHD before and after the RCT program and in 12 healthy control children twice. For fMRI, a Go/No-go paradigm was used to investigate the influence of RCT training on attention and impulsivity. The No-go condition revealed only weak activation in the dorsal part of the anterior cingulate cortex (ACC), parietal and dorsolateral prefrontal cortex (DLPFC) before the training in children with ADHD compared to healthy children. However, this activation in these brain regions was significantly more pronounced after the training. This increase in hemodynamic response cannot be attributed merely to repetition of the measurement since the effect was not observed in healthy children. The increase in hemodynamic response in the ACC and right DLPFC was significantly associated with a reduction in response time variability and clinical symptoms in ADHD patients. After the RCT training, the children with ADHD demonstrated more pronounced activation of cortical structures which are typically related to response monitoring and self-control. It seems likely that children with ADHD learned more cognitive control in a continuous performance task as was revealed by both neuropsychological outcome and fMRI.

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Title: Behavioural Treatment Increases Activity in the Cognitive Neuronal Networks in Children with Attention Deficit/Hyperactivity Disorder
Authors: Michael Siniatchkin
Nora Glatthaar
Gabriele Gerber von Müller
Alexander Prehn-Kristensen
Stephan Wolff
Silja Knöchel
Elisabeth Steinmann
Anna Sotnikova
Ulrich Stephani
Franz Petermann
Wolf-Dieter Gerber
Publication date: 01-07-2012
Publisher: Springer US
Published in: Brain Topography / Issue 3/2012
Print ISSN: 0896-0267
Electronic ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-012-0221-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Behavioural Treatment Increases Activity in the Cognitive Neuronal Networks in Children with Attention Deficit/Hyperactivity Disorder

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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