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AIDS and Behavior
Published in: AIDS and Behavior 6/2015

01-06-2015 | Original Paper

Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS

Authors: Michael D. Wirth, Jason R. Jaggers, Wesley D. Dudgeon, James R. Hébert, Shawn D. Youngstedt, Steven N. Blair, Gregory A. Hand

Published in: AIDS and Behavior | Issue 6/2015

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Abstract

This study examined associations of sleep and minutes spent in moderate-vigorous physical activity (MVPA) with C-reactive protein (CRP) and interleukin (IL)-6 among persons living with HIV. Cross-sectional analyses (n = 45) focused on associations of inflammatory outcomes (i.e., CRP and IL-6) with actigraph-derived sleep duration, latency, and efficiency; sleep onset; wake time; and wake-after-sleep-onset; as well as MVPA. Least square means for CRP and IL-6 by levels of sleep and MVPA were computed from general linear models. Individuals below the median of sleep duration, above the median for sleep onset, and below the median of MVPA minutes had higher CRP or IL-6 levels. Generally, individuals with both low MVPA and poor sleep characteristics had higher inflammation levels than those with more MVPA and worse sleep. Understanding the combined impact of multiple lifestyle/behavioral factors on inflammation could inform intervention strategies to reduce inflammation and therefore, chronic disease risk.
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Literature
1.
Breslau N, Roth T, Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996;39(6):411–8.PubMedCrossRef
2.
3.
4.
Gallicchio L, Kalesan B. Sleep duration and mortality: a systematic review and meta-analysis. J Sleep Res. 2009;18(2):148–58.PubMedCrossRef
5.
Keibel A, Singh V, Sharma MC. Inflammation, microenvironment, and the immune system in cancer progression. Curr Pharm Des. 2009;15(17):1949–55.PubMedCrossRef
6.
Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev. 2007;65(12 Pt 2):S140–6.PubMedCrossRef
7.
Ahmadi-Abhari S, Luben RN, Wareham NJ, Khaw KT. Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study. Eur J Epidemiol. 2013;28(7):541–50.PubMedCrossRef
8.
Vrints H, Shivalkar B, Hilde H, et al. Cardiovascular mechanisms and consequences of obstructive sleep apnoea. Acta Clin Belg. 2013;68(3):169–78.PubMedCrossRef
9.
Nadeem R, Molnar J, Madbouly EM, et al. Serum inflammatory markers in obstructive sleep apnea: a meta-analysis. J Clin Sleep Med. 2013;9(10):1003–12.PubMedCentralPubMed
10.
Solarz DE, Mullington JM, Meier-Ewert HK. Sleep, inflammation and cardiovascular disease. Front Biosci (Elite Ed). 2012;4:2490–501.PubMedCrossRef
11.
Chennaoui M, Sauvet F, Drogou C, et al. Effect of one night of sleep loss on changes in tumor necrosis factor alpha (TNF-alpha) levels in healthy men. Cytokine. 2011;56(2):318–24.PubMedCrossRef
12.
Pejovic S, Basta M, Vgontzas AN, et al. Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance. Am J Physiol Endocrinol Metab. 2013;305(7):E890–6.PubMedCentralPubMedCrossRef
13.
Ferrie JE, Kivimaki M, Akbaraly TN, et al. Associations between change in sleep duration and inflammation: findings on C-reactive protein and interleukin 6 in the Whitehall II Study. Am J Epidemiol. 2013;178(6):956–61.PubMedCentralPubMedCrossRef
14.
Grandner MA, Buxton OM, Jackson N, Sands-Lincoln M, Pandey A, Jean-Louis G. Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group. Sleep. 2013;36(5):769E–79E.
15.
Wiener RC, Zhang R, Shankar A. Elevated serum C-reactive protein and markers of sleep disordered breathing. Int J Vasc Med. 2012;2012:914593.PubMedCentralPubMed
16.
Matthews KA, Zheng H, Kravitz HM, et al. Are inflammatory and coagulation biomarkers related to sleep characteristics in mid-life women?: study of women’s health across the nation sleep study. Sleep. 2010;33(12):1649–55.PubMedCentralPubMed
17.
Jackowska M, Kumari M, Steptoe A. Sleep and biomarkers in the english longitudinal study of ageing: associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin. Psychoneuroendocrinology. 2013;38(9):1484–93.PubMedCrossRef
18.
19.
Prather AA, Epel ES, Cohen BE, Neylan TC, Whooley MA. Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: findings from the heart and soul study. J Psychiatr Res. 2013;47(9):1228–35.PubMedCrossRef
20.
Main LC, Dawson B, Heel K, Grove JR, Landers GJ, Goodman C. Relationship between inflammatory cytokines and self-report measures of training overload. Res Sports Med. 2010;18(2):127–39.PubMedCrossRef
21.
Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB. Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Biol Psychol. 2009;82(1):12–7.PubMedCentralPubMedCrossRef
22.
Okun ML, Coussons-Read M, Hall M. Disturbed sleep is associated with increased C-reactive protein in young women. Brain Behav Immun. 2009;23(3):351–4.PubMedCentralPubMedCrossRef
23.
Suarez EC. Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. Brain Behav Immun. 2008;22(6):960–8.PubMedCentralPubMedCrossRef
24.
Liukkonen T, Rasanen P, Ruokonen A, et al. C-reactive protein levels and sleep disturbances: observations based on the Northern Finland 1966 Birth Cohort study. Psychosom Med. 2007;69(8):756–61.PubMedCrossRef
25.
Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E. Correlates of serum C-reactive protein (CRP)—no association with sleep duration or sleep disordered breathing. Sleep. 2007;30(8):991–6.PubMedCentralPubMed
26.
Fornadi K, Lindner A, Czira ME, et al. Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients. Int Urol Nephrol. 2012;44(2):607–17.PubMedCrossRef
27.
Dowd JB, Goldman N, Weinstein M. Sleep duration, sleep quality, and biomarkers of inflammation in a Taiwanese population. Ann Epidemiol. 2011;21(11):799–806.PubMedCentralPubMedCrossRef
28.
Miller MA, Kandala NB, Kivimaki M, et al. Gender differences in the cross-sectional relationships between sleep duration and markers of inflammation: Whitehall II study. Sleep. 2009;32(7):857–64.PubMedCentralPubMed
29.
Lopresti AL, Hood SD, Drummond PD. A review of lifestyle factors that contribute to important pathways associated with major depression: diet, sleep and exercise. J Affect Disord. 2013;148(1):12–27.PubMedCrossRef
30.
Santos RV, Tufik S, De Mello MT. Exercise, sleep and cytokines: is there a relation? Sleep Med Rev. 2007;11(3):231–9.PubMedCrossRef
31.
32.
Youngstedt SD, Kline CE. Epidemiology of exercise and sleep. Sleep Biol Rhythm. 2006;4:215–21.CrossRef
33.
Zielinski MR, Davis JM, Fadel JR, Youngstedt SD. Influence of chronic moderate sleep restriction and exercise on inflammation and carcinogenesis in mice. Brain Behav Immun. 2012;26(4):672–9.PubMedCentralPubMedCrossRef
34.
Robbins JL, Phillips KD, Dudgeon WD, Hand GA. Physiological and psychological correlates of sleep in HIV infection. Clin Nurs Res. 2004;13(1):33–52.PubMedCrossRef
35.
Gallego L, Barreiro P, del Rio R, et al. Analyzing sleep abnormalities in HIV-infected patients treated with Efavirenz. Clin Infect Dis. 2004;38(3):430–2.PubMedCrossRef
36.
Blanch J, Martinez E, Rousaud A, et al. Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz. J Acquir Immune Defic Syndr. 2001;27(4):336–43.PubMedCrossRef
37.
Hand GA, Phillips KD, Dudgeon WD, William Lyerly G, Larry Durstine J, Burgess SE. Moderate intensity exercise training reverses functional aerobic impairment in HIV-infected individuals. AIDS Care. 2008;20(9):1066–74.PubMedCrossRef
38.
Bopp CM, Phillips KD, Fulk LJ, Hand GA. Clinical implications of therapeutic exercise in HIV/AIDS. J Assoc Nurs AIDS Care. 2003;14(1):73–8.CrossRef
39.
Yahiaoui A, McGough EL, Voss JG. Development of evidence-based exercise recommendations for older HIV-infected patients. J Assoc Nurs AIDS Care. 2012;23(3):204–19.CrossRef
40.
Hand GA, Lyerly GW, Jaggers JR, Dudgeon WD. Impact of aerobic and resistance exercise on the health of HIV-infected persons. Am J Lifestyle Med. 2009;3(6):489–99.PubMedCentralPubMedCrossRef
41.
42.
Brigham EP, Patil SP, Jacobson LP, et al. Association between systemic inflammation and obstructive sleep apnea in men with or at risk for HIV infection. Antivir Ther. 2014. doi:10.​3851/​IMP2745.
43.
Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol. 2008;214(2):231–41.PubMedCrossRef
44.
45.
46.
Jaggers JR, Dudgeon W, Blair SN, et al. A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial. BMC Public Health. 2013;13:502.PubMedCentralPubMedCrossRef
47.
Welk GJ, McClain JJ, Eisenmann JC, Wickel EE. Field validation of the MTI Actigraph and BodyMedia armband monitor using the IDEEA monitor. Obesity (Silver Spring). 2007;15(4):918–28.CrossRef
48.
St-Onge M, Mignault D, Allison DB, Rabasa-Lhoret R. Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am J Clin Nutr. 2007;85(3):742–9.PubMed
49.
Peterson BT, Chiao P, Pickering E, et al. Comparison of actigraphy and polysomnography to assess effects of zolpidem in a clinical research unit. Sleep Med. 2012;13(4):419–24.PubMedCrossRef
50.
Soric M, Turkalj M, Kucic D, Marusic I, Plavec D, Misigoj-Durakovic M. Validation of a multi-sensor activity monitor for assessing sleep in children and adolescents. Sleep Med. 2013;14(2):201–5.PubMedCrossRef
51.
O’Driscoll DM, Turton AR, Copland JM, Strauss BJ, Hamilton GS. Energy expenditure in obstructive sleep apnea: validation of a multiple physiological sensor for determination of sleep and wake. Sleep Breath. 2013;17(1):139–46.PubMedCrossRef
52.
Sharif MM, Bahammam AS. Sleep estimation using BodyMedia’s sensewear armband in patients with obstructive sleep apnea. Ann Thorac Med. 2013;8(1):53–7.PubMedCentralPubMedCrossRef
53.
Sallis JF, Grossman RM, Pinski RB, Patterson TL, Nader PR. The development of scales to measure social support for diet and exercise behaviors. Prev Med. 1987;16(6):825–36.PubMedCrossRef
54.
Marcus BH, Rakowski W, Rossi JS. Assessing motivational readiness and decision making for exercise. Health Psychol. 1992;11(4):257–61.PubMedCrossRef
55.
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24(4):385–96.PubMedCrossRef
56.
Skinner HA, Sheu WJ. Reliability of alcohol use indices. The lifetime drinking history and the MAST. J Stud Alcohol. 1982;43(11):1157–70.PubMedCrossRef
57.
Marcus BH, Rossi JS, Selby VC, Niaura RS, Abrams DB. The stages and processes of exercise adoption and maintenance in a worksite sample. Health Psychol. 1992;11(6):386–95.PubMedCrossRef
58.
McHorney CA, Ware JE Jr, Lu JF, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care. 1994;32(1):40–66.PubMedCrossRef
59.
Trotti LM, Rye DB, De Staercke C, Hooper WC, Quyyumi A, Bliwise DL. Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome. Brain Behav Immun. 2012;26(8):1239–43.PubMedCentralPubMedCrossRef
60.
Zhang J, Lamers F, Hickie IB, He JP, Feig E, Merikangas KR. Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates. Sleep. 2013;36(5):671–9.PubMedCentralPubMed
61.
Kline CE, Zielinski MR, Devlin TM, Kripke DF, Bogan RK, Youngstedt SD. Self-reported long sleep in older adults is closely related to objective time in bed. Sleep Biol Rhythm. 2010;8(1):42–51.CrossRef
62.
63.
Youngstedt SD, Jean-Louis G, Bootzin RR, et al. Chronic moderate sleep restriction in older long sleepers and older average duration sleepers: a randomized controlled trial. Contemp Clin Trials. 2013;36(1):175–86.PubMedCrossRef
64.
Youngstedt SD, Kripke DF. Long sleep and mortality: rationale for sleep restriction. Sleep Med Rev. 2004;8(3):159–74.PubMedCrossRef
65.
Golombek DA, Casiraghi LP, Agostino PV, et al. The times they’re a-changing: effects of circadian desynchronization on physiology and disease. J Physiol Paris. 2013;107(4):310–22.PubMedCrossRef
66.
67.
Ferrando S, Evans S, Goggin K, Sewell M, Fishman B, Rabkin J. Fatigue in HIV illness: relationship to depression, physical limitations, and disability. Psychosom Med. 1998;60(6):759–64.PubMedCrossRef
68.
Cruess DG, Antoni MH, Gonzalez J, et al. Sleep disturbance mediates the association between psychological distress and immune status among HIV-positive men and women on combination antiretroviral therapy. J Psychosom Res. 2003;54(3):185–9.PubMedCrossRef
69.
Bahammam AS, Alaseem AM, Alzakri AA, Sharif MM. The effects of Ramadan fasting on sleep patterns and daytime sleepiness: an objective assessment. J Res Med Sci. 2013;18(2):127–31.PubMedCentralPubMed
70.
Al Otair H, Al-Shamiri M, Bahobail M, Sharif MM, BaHammam AS. Assessment of sleep patterns, energy expenditure and circadian rhythms of skin temperature in patients with acute coronary syndrome. Med Sci Monit. 2011;17(7):CR397–403.PubMedCrossRef
71.
Pardo CA, McArthur JC, Griffin JW. HIV neuropathy: insights in the pathology of HIV peripheral nerve disease. J Peripher Nerv Syst. 2001;6(1):21–7.PubMedCrossRef
72.
Wulff EA, Wang AK, Simpson DM. HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment. Drugs. 2000;59(6):1251–60.PubMedCrossRef
Metadata
Title
Association of Markers of Inflammation with Sleep and Physical Activity Among People Living with HIV or AIDS
Authors
Michael D. Wirth
Jason R. Jaggers
Wesley D. Dudgeon
James R. Hébert
Shawn D. Youngstedt
Steven N. Blair
Gregory A. Hand
Publication date
01-06-2015
Publisher
Springer US
Published in
AIDS and Behavior / Issue 6/2015
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0949-y

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