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Published in: AIDS and Behavior 8/2015

01-08-2015 | Original Paper

Looking Beyond Health-Related Quality of Life: Predictors of Subjective Well-Being among People Living with HIV in the Netherlands

Authors: Edwin J. M. Oberjé, Alexandra L. Dima, Astrid G. W. van Hulzen, Jan M. Prins, Marijn de Bruin

Published in: AIDS and Behavior | Issue 8/2015

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Abstract

Health care interventions are increasingly expected to improve subjective well-being (SWB) rather than health-related quality of life (HRQOL) only. However, little is known about how HRQOL and other relevant quality of life (QOL) domains relate to SWB among people living with HIV. People living with HIV treated in Dutch HIV centers (n = 191) completed a cross-sectional survey on SWB, HRQOL, and other QOL domains (social, financial, sexual, and environmental well-being). In bivariate analyses, all QOL domains were significantly related to SWB (r = .17 to .42). In structural equation models, physical health (β = .14; p < .05), mental health (β = .27; p < .01), and environmental well-being (β = .41; p < .01) directly predicted SWB, while financial and social well-being explained SWB indirectly. Thus, environmental well-being and mental health are the main predictors of SWB, and physical health, social well-being, and financial well-being to a lesser extent. Given that most of HIV-care is directed at improving physical health, from the perspective of promoting SWB HIV care should also be directed at other life domains.
Literature
1.
go back to reference Remor E, Fuster MJ, Ballester-Arnal R, et al. Development of a new instrument for the assessment of psychological predictors of well-being and quality of life in people with HIV or AIDS. AIDS Behav. 2012;16(8):2414–23.PubMedCrossRef Remor E, Fuster MJ, Ballester-Arnal R, et al. Development of a new instrument for the assessment of psychological predictors of well-being and quality of life in people with HIV or AIDS. AIDS Behav. 2012;16(8):2414–23.PubMedCrossRef
2.
go back to reference Lin MK, Wu AW, Revicki DA. Incorporating quality of life measures in HIV clinical trials. HIV Clin Trials. 2002;3(3):202–18.PubMedCrossRef Lin MK, Wu AW, Revicki DA. Incorporating quality of life measures in HIV clinical trials. HIV Clin Trials. 2002;3(3):202–18.PubMedCrossRef
4.
go back to reference Gakhar H, Kamali A, Holodniy M. Health-related quality of life assessment after antiretroviral therapy: a review of the literature. Drugs. 2013;73:1–22.CrossRef Gakhar H, Kamali A, Holodniy M. Health-related quality of life assessment after antiretroviral therapy: a review of the literature. Drugs. 2013;73:1–22.CrossRef
5.
go back to reference Brazier J, Roberts J, Deverill M. The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002;21(2):271–92.PubMedCrossRef Brazier J, Roberts J, Deverill M. The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002;21(2):271–92.PubMedCrossRef
6.
go back to reference Rabin R, Charro F. EQ-SD: a measure of health status from the EuroQol group. Ann Med. 2001;33(5):337–43.PubMedCrossRef Rabin R, Charro F. EQ-SD: a measure of health status from the EuroQol group. Ann Med. 2001;33(5):337–43.PubMedCrossRef
7.
go back to reference Furlong WJ, Feeny DH, Torrance GW, Barr RD. The health utilities index (HUI) system for assessing health-related quality of life in clinical studies. Ann Med. 2001;33(5):375–84.PubMedCrossRef Furlong WJ, Feeny DH, Torrance GW, Barr RD. The health utilities index (HUI) system for assessing health-related quality of life in clinical studies. Ann Med. 2001;33(5):375–84.PubMedCrossRef
8.
go back to reference Wilson IB, Cleary PC. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. J Am Med Assoc. 1995;273(1):59–65.CrossRef Wilson IB, Cleary PC. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. J Am Med Assoc. 1995;273(1):59–65.CrossRef
9.
go back to reference Oberjé EJ, de Kinderen RJ, Evers SM, van Woerkum CM, de Bruin M. Cost effectiveness of medication adherence-enhancing interventions: a systematic review of trial-based economic evaluations. Pharmacoeconomics. 2013;31(12):1155–68.PubMedCrossRef Oberjé EJ, de Kinderen RJ, Evers SM, van Woerkum CM, de Bruin M. Cost effectiveness of medication adherence-enhancing interventions: a systematic review of trial-based economic evaluations. Pharmacoeconomics. 2013;31(12):1155–68.PubMedCrossRef
10.
go back to reference Constanza R, Fisher B, Ali S, et al. Quality of life: an approach integrating opportunities, human needs, and subjective well-being. Ecol Econ. 2007;61(2–3):267–76.CrossRef Constanza R, Fisher B, Ali S, et al. Quality of life: an approach integrating opportunities, human needs, and subjective well-being. Ecol Econ. 2007;61(2–3):267–76.CrossRef
12.
go back to reference Alayli-Goebbels AF, Evers SM, Alexeeva D, et al. A review of economic evaluations of behavior change interventions: setting an agenda for research methods and practice. J Public Health. 2014;36(2):336–44.CrossRef Alayli-Goebbels AF, Evers SM, Alexeeva D, et al. A review of economic evaluations of behavior change interventions: setting an agenda for research methods and practice. J Public Health. 2014;36(2):336–44.CrossRef
13.
go back to reference Ryan RM, Deci EL. On happiness and human potentials: a review of research on hedonic and eudaimonic well-being. Annu Rev Psychol. 2001;52:141–66.PubMedCrossRef Ryan RM, Deci EL. On happiness and human potentials: a review of research on hedonic and eudaimonic well-being. Annu Rev Psychol. 2001;52:141–66.PubMedCrossRef
14.
go back to reference Diener E. Guidelines for national indicators of subjective well-being and ill-being. Appl Res Qual Life. 2006;1(2):151–7.CrossRef Diener E. Guidelines for national indicators of subjective well-being and ill-being. Appl Res Qual Life. 2006;1(2):151–7.CrossRef
15.
go back to reference Diener E, Oishi S, Ryan KL. Universals and cultural differences in the causes and structure of happiness: a multilevel review. In: Keyes C, editor. Mental well-being. Dordrecht: Springer; 2010. p. 153–76. Diener E, Oishi S, Ryan KL. Universals and cultural differences in the causes and structure of happiness: a multilevel review. In: Keyes C, editor. Mental well-being. Dordrecht: Springer; 2010. p. 153–76.
16.
go back to reference Diener E, Emmons RA, Larsen RJ, Griffin S. The satisfaction with life scale. J Pers Assess. 1985;49(1):71–5.PubMedCrossRef Diener E, Emmons RA, Larsen RJ, Griffin S. The satisfaction with life scale. J Pers Assess. 1985;49(1):71–5.PubMedCrossRef
17.
go back to reference Diener E, Suh EM, Lucas RE, Smith HL. Subjective well-being: three decades of progress. Psychol Bull. 1999;125(2):276–302.CrossRef Diener E, Suh EM, Lucas RE, Smith HL. Subjective well-being: three decades of progress. Psychol Bull. 1999;125(2):276–302.CrossRef
18.
go back to reference Busseri MA, Sadava SW. A review of the tripartite structure of subjective well-being: implications for conceptualization, operationalization, analysis, and synthesis. Pers Soc Psychol Rev. 2011;15(3):290–314.PubMedCrossRef Busseri MA, Sadava SW. A review of the tripartite structure of subjective well-being: implications for conceptualization, operationalization, analysis, and synthesis. Pers Soc Psychol Rev. 2011;15(3):290–314.PubMedCrossRef
19.
go back to reference Davern MT, Cummins RA, Stokes MA. Subjective well-being as an affective-cognitive construct. J Happiness Stud. 2007;8(4):429–49.CrossRef Davern MT, Cummins RA, Stokes MA. Subjective well-being as an affective-cognitive construct. J Happiness Stud. 2007;8(4):429–49.CrossRef
20.
go back to reference Lucas RE. Using structural equation models to validate measures of positive emotions. In: Ong AD, van Dulmen MH, editors. Oxford handbook of methods in positive psychology. New York: Oxford University Press; 2007. p. 111–25. Lucas RE. Using structural equation models to validate measures of positive emotions. In: Ong AD, van Dulmen MH, editors. Oxford handbook of methods in positive psychology. New York: Oxford University Press; 2007. p. 111–25.
21.
go back to reference Eller LS, Mahat G. Predictors of life satisfaction in HIV-positive Nepali women. J Assoc Nurses AIDS Care. 2007;18(5):17–26.PubMedCrossRef Eller LS, Mahat G. Predictors of life satisfaction in HIV-positive Nepali women. J Assoc Nurses AIDS Care. 2007;18(5):17–26.PubMedCrossRef
22.
go back to reference Heckman TG, Somlai AM, Sikkema KJ, Kelly JA, Franzoi SL. Psychosocial predictors of life satisfaction among persons living with HIV infection and AIDS. J Assoc Nurses AIDS Care. 1997;8(5):21–30.PubMedCrossRef Heckman TG, Somlai AM, Sikkema KJ, Kelly JA, Franzoi SL. Psychosocial predictors of life satisfaction among persons living with HIV infection and AIDS. J Assoc Nurses AIDS Care. 1997;8(5):21–30.PubMedCrossRef
23.
go back to reference Heckman TG. The chronic illness quality of life (CIQOL) model: explaining life satisfaction in people living with HIV disease. Health Psychol. 2003;22(2):140–7.PubMedCrossRef Heckman TG. The chronic illness quality of life (CIQOL) model: explaining life satisfaction in people living with HIV disease. Health Psychol. 2003;22(2):140–7.PubMedCrossRef
24.
go back to reference Keltner JR, Vaida F, Ellis RJ, et al. Health-related quality of life ‘well-being’ in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity. Psychosom. 2012;54(4):380–6.CrossRef Keltner JR, Vaida F, Ellis RJ, et al. Health-related quality of life ‘well-being’ in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity. Psychosom. 2012;54(4):380–6.CrossRef
25.
go back to reference Ramírez-Marrero FA, Smith BA, Meléndez-Brau N, Santana-Bagur JL. Physical and leisure activity, body composition, and life satisfaction in HIV-positive Hispanics in Puerto Rico. J Assoc Nurses AIDS Care. 2004;15(4):68–77.PubMedCrossRef Ramírez-Marrero FA, Smith BA, Meléndez-Brau N, Santana-Bagur JL. Physical and leisure activity, body composition, and life satisfaction in HIV-positive Hispanics in Puerto Rico. J Assoc Nurses AIDS Care. 2004;15(4):68–77.PubMedCrossRef
26.
go back to reference O’Cleirigh C, Safren SA. Domains of life satisfaction among patients living with HIV: a factor analytic study of the quality of live inventory. AIDS Behav. 2006;10(1):53–8.PubMedCrossRef O’Cleirigh C, Safren SA. Domains of life satisfaction among patients living with HIV: a factor analytic study of the quality of live inventory. AIDS Behav. 2006;10(1):53–8.PubMedCrossRef
27.
go back to reference Safren SA, Radomsky AS, Otto MW, Salomon E. Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy. Psychosom. 2002;43(6):478–85.CrossRef Safren SA, Radomsky AS, Otto MW, Salomon E. Predictors of psychological well-being in a diverse sample of HIV-positive patients receiving highly active antiretroviral therapy. Psychosom. 2002;43(6):478–85.CrossRef
28.
go back to reference Buseh AG, Kelber ST, Hewitt JB, Stevens PE, Park CG. Perceived stigma and life satisfaction: experiences of urban African American men living with HIV/AIDS. Int J Mens Health. 2006;5(1):35–51.CrossRef Buseh AG, Kelber ST, Hewitt JB, Stevens PE, Park CG. Perceived stigma and life satisfaction: experiences of urban African American men living with HIV/AIDS. Int J Mens Health. 2006;5(1):35–51.CrossRef
29.
go back to reference Skevington SM. Is quality of life poorer for older adults with HIV/AIDS? International evidence using the WHOQOL-HIV. AIDS Care. 2012;24(10):1219–25.PubMedCrossRef Skevington SM. Is quality of life poorer for older adults with HIV/AIDS? International evidence using the WHOQOL-HIV. AIDS Care. 2012;24(10):1219–25.PubMedCrossRef
30.
go back to reference Greeff M, Uys LR, Wantland D, et al. Perceived HIV stigma and life satisfaction among persons living with HIV infection in five african countries: a longitudinal study. Int J Nurs Stud. 2010;47(4):475–86.PubMedCentralPubMedCrossRef Greeff M, Uys LR, Wantland D, et al. Perceived HIV stigma and life satisfaction among persons living with HIV infection in five african countries: a longitudinal study. Int J Nurs Stud. 2010;47(4):475–86.PubMedCentralPubMedCrossRef
31.
go back to reference Hutton VE, Misajon R, Collins FE. Subjective wellbeing and ‘felt’ stigma when living with HIV. Qual Life Res. 2012;22:65–73.CrossRef Hutton VE, Misajon R, Collins FE. Subjective wellbeing and ‘felt’ stigma when living with HIV. Qual Life Res. 2012;22:65–73.CrossRef
32.
go back to reference Earnshaw VA, Smith LR, Chaudoir SR, Amico R, Copenhaver MM. HIV stigma mechanisms and well-being among PLWH: a test of the stigma framework. AIDS Behav. 2013;17(5):1785–95.PubMedCentralPubMedCrossRef Earnshaw VA, Smith LR, Chaudoir SR, Amico R, Copenhaver MM. HIV stigma mechanisms and well-being among PLWH: a test of the stigma framework. AIDS Behav. 2013;17(5):1785–95.PubMedCentralPubMedCrossRef
33.
go back to reference Camfield L, Skevington SM. On subjective well-being and quality of life. J Health Psychol. 2008;13(6):764–75.PubMedCrossRef Camfield L, Skevington SM. On subjective well-being and quality of life. J Health Psychol. 2008;13(6):764–75.PubMedCrossRef
34.
go back to reference Longmire-Avital B, Golub SA, Parsons JT, Brennan-Ing M, Karpiak SE. Financial hardship and life satisfaction among aging African Americans with HIV. J HIV/AIDS Soc Serv. 2012;11(4):363–74.CrossRef Longmire-Avital B, Golub SA, Parsons JT, Brennan-Ing M, Karpiak SE. Financial hardship and life satisfaction among aging African Americans with HIV. J HIV/AIDS Soc Serv. 2012;11(4):363–74.CrossRef
35.
go back to reference Anderson R. Positive sexuality and its impact on overall well-being. Bundesgesundheitsblatt—Gesundheitsforschung—Gesundheitsschutz. 2013;56(2):208–14. Anderson R. Positive sexuality and its impact on overall well-being. Bundesgesundheitsblatt—Gesundheitsforschung—Gesundheitsschutz. 2013;56(2):208–14.
36.
37.
go back to reference The WHOQOL group. The World Health Organization quality of life assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46:1569–85.CrossRef The WHOQOL group. The World Health Organization quality of life assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46:1569–85.CrossRef
38.
go back to reference Oberjé E, de Bruin M, Evers S, et al. Cost-effectiveness of a nurse-based intervention (AIMS) to improve adherence among HIV-infected patients: design of a multi-centre randomised controlled trial. BMC Health Serv Res. 2013;13:274.PubMedCentralPubMedCrossRef Oberjé E, de Bruin M, Evers S, et al. Cost-effectiveness of a nurse-based intervention (AIMS) to improve adherence among HIV-infected patients: design of a multi-centre randomised controlled trial. BMC Health Serv Res. 2013;13:274.PubMedCentralPubMedCrossRef
39.
go back to reference de Bruin M, Hospers HJ, van Breukelen GJP, Kok G, Koevoets WM, Prins JM. Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. Health Psychol. 2010;29(4):421–8.PubMedCrossRef de Bruin M, Hospers HJ, van Breukelen GJP, Kok G, Koevoets WM, Prins JM. Electronic monitoring-based counseling to enhance adherence among HIV-infected patients: a randomized controlled trial. Health Psychol. 2010;29(4):421–8.PubMedCrossRef
40.
go back to reference de Bruin M, Hospers HJ, van den Borne HW, Kok G, Prins JM. Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. AIDS Patient Care STDs. 2005;19(6):384–94.PubMedCrossRef de Bruin M, Hospers HJ, van den Borne HW, Kok G, Prins JM. Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. AIDS Patient Care STDs. 2005;19(6):384–94.PubMedCrossRef
41.
go back to reference Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.PubMedCrossRef Ware JE, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.PubMedCrossRef
42.
go back to reference Ware JE, Kosinski M, Turner-Bowker DM, Gandek B. How to score version 2 of the SF-12 health survey (with a supplement documenting version 1). Lincoln: Quality-Metric Incorporated. 2000. Ware JE, Kosinski M, Turner-Bowker DM, Gandek B. How to score version 2 of the SF-12 health survey (with a supplement documenting version 1). Lincoln: Quality-Metric Incorporated. 2000.
43.
go back to reference Aaronson NK, Muller M, Cohen PD, et al. Translation, validation, and norming of the dutch language version of the SF-36 health survey in community and chronic disease populations. J Clin Epidemiol. 1998;51(11):1055–68.PubMedCrossRef Aaronson NK, Muller M, Cohen PD, et al. Translation, validation, and norming of the dutch language version of the SF-36 health survey in community and chronic disease populations. J Clin Epidemiol. 1998;51(11):1055–68.PubMedCrossRef
44.
go back to reference Arrindell WA, Meeuwesen L, Huyse FJ. The satisfaction with life scale (SWLS): psychometric properties in a non-psyhiatric medical outpatients sample. Pers Indiv Differ. 1991;12(2):117–23.CrossRef Arrindell WA, Meeuwesen L, Huyse FJ. The satisfaction with life scale (SWLS): psychometric properties in a non-psyhiatric medical outpatients sample. Pers Indiv Differ. 1991;12(2):117–23.CrossRef
45.
go back to reference de Vries J, van Heck GL. The World Health Organization quality of life assessment instrument (WHOQOL-100): validation study with the Dutch version. Eur J Psychol Assess. 1997;13(3):164–78.CrossRef de Vries J, van Heck GL. The World Health Organization quality of life assessment instrument (WHOQOL-100): validation study with the Dutch version. Eur J Psychol Assess. 1997;13(3):164–78.CrossRef
46.
go back to reference Schumacker RE. Teacher’s corner: conducting specification searches with AMOS. Struct Equ Modeling. 2006;13(1):118–29.CrossRef Schumacker RE. Teacher’s corner: conducting specification searches with AMOS. Struct Equ Modeling. 2006;13(1):118–29.CrossRef
47.
go back to reference Schreiber JB, Nora A, Stage FK, Barlow EA, King J. Reporting structural equation modeling and confirmatory factor analysis results: a review. J Educ Res. 2006;99(6):323–38.CrossRef Schreiber JB, Nora A, Stage FK, Barlow EA, King J. Reporting structural equation modeling and confirmatory factor analysis results: a review. J Educ Res. 2006;99(6):323–38.CrossRef
48.
go back to reference Stichting HIV Monitoring. Annual Report 2012. Amsterdam, 2012. Stichting HIV Monitoring. Annual Report 2012. Amsterdam, 2012.
49.
go back to reference Diener E, Biswas-Diener R. Happiness: unlocking the mysteries of psychological wealth. Malden: Wiley-Blackwell; 2011. Diener E, Biswas-Diener R. Happiness: unlocking the mysteries of psychological wealth. Malden: Wiley-Blackwell; 2011.
50.
go back to reference Headey B, Kelley J, Wearing A. Dimensions of mental health: life satisfaction, positive affect, anxiety and depression. Soc Indic Res. 1993;29(1):63–82.CrossRef Headey B, Kelley J, Wearing A. Dimensions of mental health: life satisfaction, positive affect, anxiety and depression. Soc Indic Res. 1993;29(1):63–82.CrossRef
51.
go back to reference Bing EG, Hays RD, Jacobson L, et al. Health-related quality of life among people living with HIV disease: results from the multicenter AIDS cohort study. Qual Life Res. 2000;9(1):55–63.PubMedCrossRef Bing EG, Hays RD, Jacobson L, et al. Health-related quality of life among people living with HIV disease: results from the multicenter AIDS cohort study. Qual Life Res. 2000;9(1):55–63.PubMedCrossRef
52.
go back to reference Call S, Klapow J, Stewart K, et al. Health-related quality of life and virologic outcomes in an HIV clinic. Qual Life Res. 2000;9(9):977–88.PubMedCrossRef Call S, Klapow J, Stewart K, et al. Health-related quality of life and virologic outcomes in an HIV clinic. Qual Life Res. 2000;9(9):977–88.PubMedCrossRef
53.
go back to reference Weinfurt KP, Willke RJ, Glick HA, Freimuth WW, Schulman KA. Relationship between CD4 count, viral burden, and quality of life over time in HIV-1-infected patients. Med Care. 2000;38(4):404–10.PubMedCrossRef Weinfurt KP, Willke RJ, Glick HA, Freimuth WW, Schulman KA. Relationship between CD4 count, viral burden, and quality of life over time in HIV-1-infected patients. Med Care. 2000;38(4):404–10.PubMedCrossRef
54.
go back to reference Forrest R, Kearns A. Social cohesion, social capital and the neighbourhood. Urban Stud. 2001;38(12):2125–43.CrossRef Forrest R, Kearns A. Social cohesion, social capital and the neighbourhood. Urban Stud. 2001;38(12):2125–43.CrossRef
55.
go back to reference Crepaz N, Passin WF, Herbst JH, et al. Meta-analysis of cognitive-behavioral interventions on HIV-positive persons’ mental health and immune functioning. Health Psychol. 2008;27(1):4–14.PubMedCrossRef Crepaz N, Passin WF, Herbst JH, et al. Meta-analysis of cognitive-behavioral interventions on HIV-positive persons’ mental health and immune functioning. Health Psychol. 2008;27(1):4–14.PubMedCrossRef
56.
go back to reference Collins PY, Insel TR, Chockalingam A, Daar A, Maddox YT. Grand challenges in global mental health: integration in research, policy, and practice. PLoS Med. 2013;10(4):e1001434.PubMedCentralPubMedCrossRef Collins PY, Insel TR, Chockalingam A, Daar A, Maddox YT. Grand challenges in global mental health: integration in research, policy, and practice. PLoS Med. 2013;10(4):e1001434.PubMedCentralPubMedCrossRef
Metadata
Title
Looking Beyond Health-Related Quality of Life: Predictors of Subjective Well-Being among People Living with HIV in the Netherlands
Authors
Edwin J. M. Oberjé
Alexandra L. Dima
Astrid G. W. van Hulzen
Jan M. Prins
Marijn de Bruin
Publication date
01-08-2015
Publisher
Springer US
Published in
AIDS and Behavior / Issue 8/2015
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0880-2

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