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Keynote webinar | Spotlight on medication adherence

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AIDS and Behavior
Published in: AIDS and Behavior 2/2011

Open Access 01-02-2011 | Original Paper

Standard Measures are Inadequate to Monitor Pediatric Adherence in a Resource-Limited Setting

Authors: Alexandra D. Müller, Heather B. Jaspan, Landon Myer, Ashley Lewis Hunter, Guy Harling, Linda-Gail Bekker, Catherine Orrell

Published in: AIDS and Behavior | Issue 2/2011

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Abstract

This study aims to compare the use and cost of objective and subjective measures of adherence to pediatric antiretroviral treatment in a primary care facility in South Africa. In a 1-month longitudinal study of 53 caregiver-child dyads, pharmacy refill (PR), measurement of returned syrups (RS), caregiver self-report (3DR) and Visual Analogue Scale (VAS) were compared to Medication Event Monitoring System (MEMS). Adherence was 100% for both VAS and 3DR; by PR and RS 100% and 103%, respectively. MEMS showed that 92% of prescribed doses were administered, but only 66% of these within the correct 12-hourly interval. None of the four measures correlated significantly with MEMS. MEMS data suggest that timing of doses is often more deviant from prescribed than expected and should be better addressed when monitoring adherence. Of all, MEMS was by far the most expensive measure. Alternative, cheaper electronic devices need to be more accessible in resource-limited settings.
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Metadata
Title
Standard Measures are Inadequate to Monitor Pediatric Adherence in a Resource-Limited Setting
Authors
Alexandra D. Müller
Heather B. Jaspan
Landon Myer
Ashley Lewis Hunter
Guy Harling
Linda-Gail Bekker
Catherine Orrell
Publication date
01-02-2011
Publisher
Springer US
Published in
AIDS and Behavior / Issue 2/2011
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-010-9825-6

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