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Open Access 12-02-2024 | Original Paper

Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length

Authors: Chloe Matheson, Tijana Simovic, Allison Heefner, Marisa Colon, Enrique Tunon, Kolton Cobb, Christopher Thode, Alison Breland, Caroline O. Cobb, Patrick Nana-Sinkam, Ryan Garten, Paula Rodriguez-Miguelez

Published in: Angiogenesis | Issue 2/2024

Abstract

Background

Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are known to cause vascular dysfunction, one of the earliest indicators of cardiovascular disease (CVD) development. However, little is known about the effect of regular e-cigarette use on vascular function. The purpose of this study was to investigate the impact of regular e-cigarette use on vascular function and cardiovascular health in young, healthy adults.

Methods

Twenty-one regular users of e-cigarettes (ECU) and twenty-one demographically matched non-users (NU) completed this study. Vascular health was assessed in the cutaneous microcirculation through different reactivity tests to evaluate overall functionality, endothelium-dependent vasodilation (EDD), and endothelium-independent vasodilation (EID). Macrovascular function was assessed using flow-mediated dilation (FMD).

Results

Our results suggest that regular users of e-cigarettes present with premature microvascular impairment when compared to non-users. Specifically, they exhibit lower hyperemic (p = 0.003), thermal (p = 0.010), and EDD (p = 0.004) responses. No differences in EID between the groups were identified. We also identified that individuals who use e-cigarettes for longer than 3 years also present with systemic manifestations, as observed by significantly reduced macrovascular (p = 0.002) and microvascular (p ≤ 0.044) function.

Conclusions

Our novel data suggests that young, apparently healthy, regular users of e-cigarettes present with premature vascular dysfunction in the microcirculation when compared to non-users. We have also identified systemic vascular dysfunction affecting both the micro and macrovasculature in those young individuals who used e-cigarettes for longer than 3 years. Taken together, these findings associate regular e-cigarette use with premature vascular dysfunctions and adverse cardiovascular outcomes.

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Title: Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
Authors: Chloe Matheson
Tijana Simovic
Allison Heefner
Marisa Colon
Enrique Tunon
Kolton Cobb
Christopher Thode
Alison Breland
Caroline O. Cobb
Patrick Nana-Sinkam
Ryan Garten
Paula Rodriguez-Miguelez
Publication date: 12-02-2024
Publisher: Springer Netherlands
Published in: Angiogenesis / Issue 2/2024
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-023-09903-7

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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Other articles of this Issue 2/2024

People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing

2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases

Role of endothelial PDGFB in arterio-venous malformations pathogenesis

Group XIV C-type lectins: emerging targets in tumor angiogenesis

Connective tissue disorders in COVID-19: Reply to “People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing”

Vascularized organoid-on-a-chip: design, imaging, and analysis

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials