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Open Access 01-02-2022 | Review Paper

Resident vascular endothelial progenitor definition and function: the age of reckoning

Authors: James Dight, Jilai Zhao, Cassandra Styke, Kiarash Khosrotehrani, Jatin Patel

Published in: Angiogenesis | Issue 1/2022

Abstract

The cardiovascular system is composed around the central function of the endothelium that lines the inner surfaces of its vessels. In recent years, the existence of a progenitor population within the endothelium has been validated through the study of endothelial colony-forming cells (ECFCs) in human peripheral blood and certain vascular beds. However, our knowledge on endothelial populations in vivo that can give rise to ECFCs in culture has been limited. In this review we report and analyse recent attempts at describing progenitor populations in vivo from murine studies that reflect the self-renewal and stemness capacity observed in ECFCs. We pinpoint seminal discoveries within the field, which have phenotypically defined, and functionally scrutinised these endothelial progenitors. Furthermore, we review recent publications utilising single-cell sequencing technologies to better understand the endothelium in homeostasis and pathology.

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Title: Resident vascular endothelial progenitor definition and function: the age of reckoning
Authors: James Dight
Jilai Zhao
Cassandra Styke
Kiarash Khosrotehrani
Jatin Patel
Publication date: 01-02-2022
Publisher: Springer Netherlands
Published in: Angiogenesis / Issue 1/2022
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-021-09817-2

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