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Esophagus
Published in: Esophagus 4/2016

01-10-2016 | Original Article

Postoperative infectious complications-driven recurrence after radical resection for esophageal cancer

Authors: Takashi Murakami, Chikara Kunisaki, Shinichi Hasegawa, Jun Kimura, Ryo Takagawa, Takashi Kosaka, Hidetaka A. Ono, Hirochika Makino, Hirotoshi Akiyama, Itaru Endo

Published in: Esophagus | Issue 4/2016

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Abstract

Background

Few reports have reported the long-term outcome of esophageal cancer patients suffering from postoperative infectious complications. Here, we investigated the impact of postoperative infectious complications in patients who had undergone curative resection for esophageal cancer.

Methods

The study population comprised 97 patients who underwent radical resection for esophageal cancer with curative intent between 2001 and 2008. Postoperative infectious complications were defined as surgical site infections and pneumonia. We compared clinical features, tumor histology, recurrence, and overall survival between patients with postoperative infections and those who did not.

Results

Of the 97 patients studied, 37 had postoperative infectious complications. The disease-free and overall survival rates of the entire cohort did not significantly differ between patients with and without postoperative infectious complications. Univariate analysis revealed that among patients with stage III esophageal cancer, those with postoperative infectious complications demonstrated significantly shorter disease-free survival than those without. Multivariate analysis demonstrated that postoperative infectious complications were independent prognostic indicators for disease-free survival of stage III esophageal cancer patients.

Conclusions

Our findings suggest that postoperative infectious complications in stage III esophageal cancer patients have a negative impact on disease-free survival.
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Metadata
Title
Postoperative infectious complications-driven recurrence after radical resection for esophageal cancer
Authors
Takashi Murakami
Chikara Kunisaki
Shinichi Hasegawa
Jun Kimura
Ryo Takagawa
Takashi Kosaka
Hidetaka A. Ono
Hirochika Makino
Hirotoshi Akiyama
Itaru Endo
Publication date
01-10-2016
Publisher
Springer Japan
Published in
Esophagus / Issue 4/2016
Print ISSN: 1612-9059
Electronic ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-016-0540-x

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