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Japanese Journal of Ophthalmology

Published in:

01-03-2013 | Clinical Investigation

Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development

Authors: Mayumi Oka, Tsutomu Yamashita, Shizuka Ono, Ikumi Kubo, Akio Tabuchi

Published in: Japanese Journal of Ophthalmology | Issue 2/2013

Abstract

Purpose

To investigate retinal morphological changes in strabismus patients with abnormal binocular vision development by comparing differences in quadrantal macular retinal thickness.

Methods

Six strabismus patients (6 dominant and 5 non-dominant eyes) with abnormal binocular vision (mean age 22 years), and 11 control subjects (11 dominant and 11 non-dominant eyes) (mean age 21 years) were enrolled. Macular retinal thickness measurements were performed by optical coherence tomography, with total macular retinal (TMR) and ganglion cell complex (GCC) thicknesses measured in 3- and 6-mm regions in each quadrant. Measurement values were then used to determine quadrant ratios.

Results

Compared to the dominant eyes of the controls, the superior/inferior (S/I) ratio of the TMR thickness and GCC thickness in the 3-mm region was significantly lower in the dominant eyes of the strabismus group (P < 0.05, each). The superior temporal/inferior temporal (ST/IT) ratio of the GCC thickness in the dominant eyes of the strabismus group was also significantly lower (P < 0.01).

Conclusions

Dominant eyes of the strabismus group with abnormal binocular vision development exhibited thinner superior temporal GCC thicknesses in the 3-mm region. Retinal ganglion cells in this region might be affected by efferent neural degeneration that originates in the visual pathway responsible for adaptations to the visual experience.

Wright KW. Clinical optokinetic nystagmus asymmetry in treated esotropes. J Pediatr Ophthalmol Strabismus. 1996;33:153–5.PubMed

van Hof-van Duin J, Mohn G. Monocular and binocular optokinetic nystagmus in humans with defective stereopsis. Invest Ophthalmol Vis Sci. 1986;27:574–83.

Tychsen L, Burkhalter A. Neuroanatomic abnormalities of primary visual cortex in macaque monkeys with infantile esotropia: preliminary results. J Pediatr Ophthalmol Strabismus. 1995;32:323–8.PubMed

Horton JC, Hocking DR, Adams DL. Metabolic mapping of suppression scotomas in striate cortex of macaques with experimental strabismus. J Neurosci. 1999;19:7111–29.PubMed

Wong AMF, Lueder GT, Brukhalter A, Tychsen L. Suppression of metabolic activity caused by infantile strabismus and strabismic amblyopia in striate visual cortex of macaque monkeys. J AAPOS. 2005;9:37–47.PubMedCrossRef

Altintas O, Yüksel N, Ozkan B, Caglar Y. Thickness of the retinal nerve fiber layer, macular thickness, and macular volume in patients with strabismic amblyopia. J Pediatr Ophthalmol Strabismus. 2005;42:216–21.PubMed

Kee SY, Lee SY, Lee YC. Thicknesses of the fovea and retinal nerve fiber layer in amblyopic and normal eyes in children. Korean J Ophthalmol. 2006;20:177–81.PubMedCrossRef

Quoc EB, Delepine B, Tran TH. Thickness of retinal nerve fiber layer and macular volume in children and adults with strabismic and anisometropic amblyopia. J Fr Ophthalmol. 2009;32:488–95.(in French).

Al-Haddad CE, Mollayess GM, Cherfan CG, Jaafar DF, Bashshur ZF. Retinal nerve fibre layer and macular thickness in amblyopia as measured by spectral-domain optical coherence tomography. Br J Ophthalmol. 2011;95:1696–9.PubMedCrossRef

10.

Dickmann A, Petroni S, Perrotta V, Salerni A, Parrilla R, Aliberti S, et al. A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry. J AAPOS. 2011;15:338–41.PubMedCrossRef

11.

Lim MC, Hoh ST, Foster PJ, Lim TH, Chew SJ, Seah SK, et al. Use of optical coherence tomography to assess variations in macular retinal thickness in myopia. Invest Ophthalmol Vis Sci. 2005;46:974–8.PubMedCrossRef

12.

Lam DS, Leung KS, Mohamed S, Chan WM, Palanivelu MS, Cheung CY, et al. Regional variations in the relationship between macular thickness measurements and myopia. Invest Ophthalmol Vis Sci. 2007;48:376–82.PubMedCrossRef

13.

Gaze RM, Keating MJ, Székely G, Beazley L. Binocular interaction in the formation of specific intertectal neuronal connexions. Proc R Soc Lond B Biol Sci. 1970;175:107–47.PubMedCrossRef

14.

Distler C, Hoffmann KP. The pupillary light reflex in normal and innate microstrabismic cats, II: retinal and cortical input to the nucleus praetectalis olivaris. Vis Neurosci. 1989;3:139–53.PubMedCrossRef

15.

Sireteanu R. Binocular luminance summation in humans with defective binocular vision. Invest Ophthalmol Vis Sci. 1987;28:349–55.PubMed

16.

Rodieck RW. Visual angle and retinal eccentricity. In: Rodieck RW, editor. The first steps in seeing. Massachusetts: Sinauer Associates; 1998. p. 125.

17.

Feldon P, Kruger L. Topography of the retinal projection upon the superior colliculus of the cat. Vision Res. 1970;10:135–43.PubMedCrossRef

18.

Curcio CA, Allen KA. Topography of ganglion cells in human retina. J Comp Neurol. 1990;300:5–25.PubMedCrossRef

19.

Fukuda Y, Sawai H, Watanabe M, Wakakuwa K, Morigiwa K. Nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections in the Japanese monkey (Macaca fuscata). J Neurosci. 1989;9:2353–73.PubMed

20.

Wright KW, Edelman PM, McVey JH, Terry AP, Lin M. High-grade stereo acuity after early surgery for congenital esotropia. Arch Ophthalmol. 1994;112:913–9.PubMedCrossRef

21.

van Rijn LJ, Simonsz HJ, Tusscher MP. Dissociated vertical deviation and eye torsion: relation to disparity-induced vertical vergence. Strabismus. 1997;5:13–20.PubMedCrossRef

22.

ten Tusscher MP, van Rijn RJ. A hypothetical mechanism for DVD: unbalanced cortical input to subcortical pathways. Strabismus. 2010;18:98–103.PubMedCrossRef

23.

Guthrie ME, Wright KW. Congenital esotropia. Ophthalmol Clin North Am. 2001;14:419–24.PubMedCrossRef

24.

Brodsky MC. Dissociated vertical divergence. A right reflex gone wrong. Arch Ophthalmol. 1999;117:1216–22.PubMedCrossRef

25.

Rodieck RW. Superior colliculus. In: Rodieck RW, editor. The first steps in seeing. Massachusetts: Sinauer Associates; 1998. p. 273–8.

26.

Takaura K, Yoshida M, Isa T. Neural substrate of spatial memory in the superior colliculus after damage to the primary visual cortex. J Neurosci. 2011;31:4233–41.PubMedCrossRef

27.

Yagasaki T, Yokoyama YO, Maeda M. Influence of timing of initial surgery for infantile esotropia on the severity of dissociated vertical deviation. Jpn J Ophthalmol. 2011;55:383–8.PubMedCrossRef

Title: Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development
Authors: Mayumi Oka
Tsutomu Yamashita
Shizuka Ono
Ikumi Kubo
Akio Tabuchi
Publication date: 01-03-2013
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 2/2013
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-012-0214-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quadrantal macular retinal thickness changes in strabismus subjects with abnormal binocular vision development

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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