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Japanese Journal of Ophthalmology

Published in:

01-09-2012 | Clinical Investigation

Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging

Authors: Masaki Tanito, Akira Obana, Yuko Gohto, Shigetoshi Okazaki, Werner Gellermann, Akihiro Ohira

Published in: Japanese Journal of Ophthalmology | Issue 5/2012

Abstract

Purpose

Our purpose was to determine whether either lutein or zeaxanthin supplementation affects macular pigment concentration/optical density (MPOD) in healthy Japanese individuals.

Methods

Twenty-two healthy volunteers were randomized to either 10 mg of orally administered lutein or zeaxanthin daily for up to 3 months. MPOD levels were measured by resonance Raman spectrophotometry (RRS) and one-wavelength autofluorescence imaging (AFI) at baseline and 1, 2, and 3 months after the start of supplementation.

Results

MPOD levels measured with each method were correlated significantly at all time points. MPOD_RRS and MPOD_AFI levels increased >20 % from baseline at 2 and 3 months after lutein supplementation. By multiple regression analyses, the refractive error was correlated positively with MPOD_RRS levels at baseline, whereas age and sex were not significant. In the lutein group, MPOD_RRS levels significantly increased from baseline at all time points in individuals without high myopia exceeding −4 diopters, whereas the increase was not observed in individuals with high myopia. In the zeaxanthin group, MPOD_RRS levels remained unchanged in those with and without high myopia.

Conclusions

MPOD_RRS and MPOD_AFI levels correlated significantly with each other. In normal healthy Japanese individuals without high myopia, lutein supplementation increased MPOD levels within the fovea more effectively than did zeaxanthin.

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Title: Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging
Authors: Masaki Tanito
Akira Obana
Yuko Gohto
Shigetoshi Okazaki
Werner Gellermann
Akihiro Ohira
Publication date: 01-09-2012
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 5/2012
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-012-0157-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Macular pigment density changes in Japanese individuals supplemented with lutein or zeaxanthin: quantification via resonance Raman spectrophotometry and autofluorescence imaging

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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